“…Junctional protein complexes recruit RhoGEFs (Juettner et al, 2019; Timmerman et al, 2015; Ngok et al, 2012; Acharya et al, 2018; Ngok et al, 2013) and RhoGAPs (Zebda et al, 2013), but they could also prevent the accessibility of these regulators, as it happens for the Rho activity suppressor p190B RhoGAP in columnar epithelial cells (Priya et al, 2015). These accessibility is regulated, for example, by mechanotransduction (Acharya et al, 2018) and may be a relevant target for endothelial hyperpermeability caused by pathological inflammation (Khan et al, 2021; Pierce et al, 2017; Khan et al, 2022)…”