ARHGAP24 regulates cell ability and apoptosis ofcolorectal cancer cells via the regulation of P53

Zhang, Suiliang; Liang, Shan; Zhuang, Juhua; He, Saifei; Song, Yanan; Ye, Ying; Xia, Weiya

doi:10.3892/ol.2018.9075

Cited by 15 publications

(12 citation statements)

References 28 publications

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“…In literature there was no clear association between the tumor recurrence and the occurrence of the p21ras protein expression, which is compliant with the observations by other authors [28][29][30]. In our own study we have also found that the level of p21 is not related to cancer recurrence.…”

Section: Discussionsupporting

confidence: 91%

P21 is not a prognostic marker for rectal cancer – five-year follow up study of rectal cancer in stages I–IV

Kozłowska-Geller

Głuszek

Lewitowicz

2020

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Section: Discussionsupporting

confidence: 91%

P21 is not a prognostic marker for rectal cancer – five-year follow up study of rectal cancer in stages I–IV

Kozłowska-Geller

Głuszek

Lewitowicz

2020

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“…The ARHGAP10 gene was found to regulate actin cytoskeleton remodeling, cell proliferation, and cell differentiation. The ARHGAP10 interacts with α-tubulin and it is involved in cell-cell adhesion processes and consequently could promote cell migration [58][59][60][61][62]. In our study, overexpression of ARHGAP10 was associated with lower meat quality index.…”

Section: Expression Association Analysis For the Meat Quality Indexsupporting

confidence: 52%

RNA-seq analysis identifies cytoskeletal structural genes and pathways for meat quality in beef

et al. 2020

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RNA sequencing (RNA-seq) has allowed for transcriptional profiling of biological systems through the identification of differentially expressed (DE) genes and pathways. A total of 80 steers with extreme phenotypes were selected from the University of Florida multibreed Angus-Brahman herd. The average slaughter age was 12.91±8.69 months. Tenderness, juiciness and connective tissue assessed by sensory panel, along with marbling, Warner-Bratzler Shear Force (WBSF) and cooking loss, were measured in longissimus dorsi muscle. Total RNA was extracted from muscle and one RNA-seq library per sample was constructed, multiplexed, and sequenced based on protocols by Illumina HiSeq-3000 platform to generate 2×101 bp paired-end reads. The overall read mapping rate using the Btau_4.6.1 reference genome was 63%. A total of 8,799 genes were analyzed using two different methodologies, an expression association and a DE analysis. A gene and exon expression association analysis was carried out using a meat quality index on all 80 samples as a continuous response variable. The expression of 208 genes and 3,280 exons from 1,565 genes was associated with the meat quality index (p-value ≤ 0.05). A gene and isoform DE evaluation was performed analyzing two groups with extreme WBSF, tenderness and marbling. A total of 676 (adjusted p-value≤0.05), 70 (adjusted p-value≤0.1) and 198 (adjusted p-value≤0.1) genes were DE for WBSF, tenderness and marbling, respectively. A total of 106 isoforms from 98 genes for WBSF, 13 isoforms from 13 genes for tenderness and 43 isoforms from 42 genes for marbling (FDR≤0.1) were DE. Cytoskeletal and transmembrane anchoring genes and pathways were identified in the expression association, DE and the gene enrichment analyses; these proteins can have a direct effect on meat quality. Cytoskeletal proteins and transmembrane anchoring molecules can influence meat quality by allowing cytoskeletal interaction with myocyte and organelle membranes, contributing to cytoskeletal structure and architecture maintenance postmortem.

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“…The ARHGAP10 gene was found to regulate actin cytoskeleton remodeling, cell proliferation, and cell differentiation. The ARHGAP10 interacts with α-tubulin and it is involved in cell-cell adhesion processes and consequently could promote cell migration [12][13][14][15][16]. In our study, overexpression of ARHGAP10 was associated with lower meat quality index.…”

Section: Gene Expression Association Analysis For the Meat Quality Indexsupporting

confidence: 52%

RNA-seq analysis identifies cytoskeletal structural genes and pathways for meat quality in beef

Gutierrez

Elzo

Mateescu

2019

Preprint

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Background RNA sequencing (RNA-seq) has allowed for transcriptional profiling of biological systems through identification of differentially expressed (DE) genes and pathways. Results A total of 80 steers were selected from the multibreed Angus-Brahman herd of the University of Florida. Sensory panel tenderness, juiciness and connective tissue as well as marbling, WBSF and cooking loss were assessed in longissimus dorsi muscle. Nuclear RNA was extracted from muscle and an RNA-seq library for each sample was constructed, multiplexed, and sequenced based on protocols by Illumina HiSeq 3000 PE100 platform to generate 2 × 101 bp paired-end reads. On average, 34.9 million high-quality paired reads were uniquely mapped to the Btau_4.6.1 reference genome and a total of 8,799 genes were analyzed. Including all 80 animals, gene and exon expression analysis was carried out using a meat quality index as a continuous response variable. The expression of 208 genes and 3,280 exons from 1,565 genes was associated with the meat quality index (p-value ≤ 0.05). Out of the 80 samples sequenced, 40 animals with extreme low and high WBSF, tenderness and marbling values were selected for a differential expression (DE) analysis for gene and isoforms. A total of 676 (adjusted p-value ≤ 0.05), 70 (adjusted p-value ≤ 0.1) and 198 (adjusted p-value ≤ 0.1) genes were DE for WBSF, tenderness and marbling, respectively. A total of 106 isoforms from 98 genes for WBSF, 13 isoforms from 13 genes for tenderness and 43 isoforms from 42 genes for marbling (FDR ≤ 0.1) were DE. Conclusion A number of cytoskeletal and transmembrane anchoring related genes and pathways were identified in the expression, DE and gene enrichment analyses, and these proteins can have a direct effect on meat quality. Cytoskeletal proteins and transmembrane anchoring molecules can influence meat quality by allowing cytoskeletal ﬁlament interaction with myocyte and organelle membranes, contributing to cytoskeletal structure, microtubule network stability, and cellular architecture maintenance during the postmortem.

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ARHGAP24 regulates cell ability and apoptosis ofcolorectal cancer cells via the regulation of P53

Cited by 15 publications

References 28 publications

P21 is not a prognostic marker for rectal cancer – five-year follow up study of rectal cancer in stages I–IV

P21 is not a prognostic marker for rectal cancer – five-year follow up study of rectal cancer in stages I–IV

RNA-seq analysis identifies cytoskeletal structural genes and pathways for meat quality in beef

RNA-seq analysis identifies cytoskeletal structural genes and pathways for meat quality in beef

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