Argyrophilic Grain Disease Presenting as Excited Catatonia: A Case Report

Kumari, Sonali; Sundararajan, Tharani; Andres, Mario; Oliver, Jonathan M.; Wright, C. Alan; Prayson, Richard A.; Havemann, Justin; Jiménez, Xavier F.

doi:10.1016/j.psym.2016.02.003

Cited by 3 publications

(3 citation statements)

References 35 publications

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“…Symptoms were clustered in categories when they occurred at least once in the identified patients or when there was prior evidence in the literature connecting this cluster to AGD [19]. Symptoms were then dichotomized into occurring or not occurring.…”

Section: Clinical Informationmentioning

confidence: 99%

“…It is associated with slowly progressive cognitive decline and can also present with prominent psychiatric symptoms at a relatively late onset, perhaps reflecting the anatomical distribution of lesions [16,17]. Urinary incontinence [18], alcohol abuse and catatonia [19] are also reported. Generally, the old age and frequent concurrence with other neurodegenerative findings [20,21] impair clear definitions and the clinical and neuropathological findings in younger patients have not been systematically described to date.…”

Section: Introductionmentioning

confidence: 99%

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Argyrophilic grain disease in individuals younger than 75 years: clinical variability in an under‐recognized limbic tauopathy

Wurm

Klotz

Rahimi³

et al. 2020

Euro J of Neurology

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Background and purpose Argyrophilic grain disease (AGD) is a limbic‐predominant 4R‐tauopathy. AGD is thought to be an age‐related disorder and is frequently detected as a concomitant pathology with other neurodegenerative conditions. There is a paucity of data on the clinical phenotype of pure AGD. In elderly patients, however, AGD pathology frequently associates with cognitive decline, personality changes, urine incontinence and cachexia. In this study, clinicopathological findings were analysed in individuals younger than 75. Methods Patients were identified retrospectively based on neuropathological examinations during 2006–2017 and selected when AGD was the primary and dominant pathological finding. Clinical data were obtained retrospectively through medical records. Results In all, 55 patients (2% of all examinations performed during that period) with AGD were identified. In seven cases (13%) AGD was the primary neuropathological diagnosis without significant concomitant pathologies. Two patients were female, median age at the time of death was 64 years (range 51–74) and the median duration of disease was 3 months (range 0.5–36). The most frequent symptoms were progressive cognitive decline, urinary incontinence, seizures and psychiatric symptoms. Brain magnetic resonance imaging revealed mild temporal atrophy. Conclusions Argyrophilic grain disease is a rarely recognized limbic tauopathy in younger individuals. Widening the clinicopathological spectrum of tauopathies may allow identification of further patients who could benefit from tau‐based therapeutic strategies.

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Section: Clinical Informationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Argyrophilic grain disease in individuals younger than 75 years: clinical variability in an under‐recognized limbic tauopathy

Wurm

Klotz

Rahimi³

et al. 2020

Euro J of Neurology

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“…A rare example of AGD has been recently described in a male suicide victim in his forties with no known significant clinical history, but who had complained to family members and colleagues of feeling weak and hypobulic [45]. Another unusual case was described in a 52-year-old male with no significant past neurological or psychiatric history and no pertinent family history or traumatic injury, who presented with late-onset psychosis and catatonia and was ultimately diagnosed with AGD on post-mortem examination [26]. One may argue that given these examples perhaps it is worthwhile to rule out AGD on post-mortem examination of patients with a clinical history of psychiatric manifestations or change in behaviour even without any known history of cognitive impairment.…”

Section: Clinical Presentationmentioning

confidence: 99%

Argyrophilic grain disease: a clinicopathological review of an overlooked tauopathy

Das¹,

Ishaque²

2018

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Argyrophilic grain disease (AGD) is a sporadic tauopathy and actually the second most frequent cause of dementia after Alzheimer's disease. Patients can present with slowly progressive cognitive decline as well as psychiatric manifestations such as depression. Definite diagnosis of AGD can only be made by post-mortem examination of the brain. Neuropathological features include argyrophilic grains in limbic areas along with oligodendroglial coiled bodies in hippocampal and amygdaloid white matter, and ballooned neurons in the amygdala. AGD, however, can often be overlooked and missed on neuropathologic examination as there are actually no specific clinical manifestations that would be considered highly suggestive of AGD. Thus, it is not uncommon to find neuropathological features of AGD in patients who do not present with any apparent neurological manifestations. The aim of this review is to provide an overview of what is currently known about AGD as well as raise its awareness among both neurologists and neuropathologists who may otherwise overlook this interesting tauopathy. We believe that patients above the age of 60 years should undergo post-mortem screening for AGD to avoid missed opportunity for diagnosis and enable future clinicopathological studies.

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Meeting Its Mission: Does Psychosomatics Align With the Mission of Its Parent Organization, the Academy of Psychosomatic Medicine?

Taylor

Stern

2017

Psychosomatics

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Argyrophilic Grain Disease Presenting as Excited Catatonia: A Case Report

Cited by 3 publications

References 35 publications

Argyrophilic grain disease in individuals younger than 75 years: clinical variability in an under‐recognized limbic tauopathy

Argyrophilic grain disease in individuals younger than 75 years: clinical variability in an under‐recognized limbic tauopathy

Argyrophilic grain disease: a clinicopathological review of an overlooked tauopathy

Meeting Its Mission: Does Psychosomatics Align With the Mission of Its Parent Organization, the Academy of Psychosomatic Medicine?

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