ARGX-111 shows activity in MET-amplified patients in a phase-I study and in preclinical models of myeloid-derived suppressor cell (MDSC) depletion in the tumor microenvironment.

Rolfo, Christian; Aftimos, Philippe; Pallandre, Jean-René; Morello, Virginia; Bouard, Adeline; Cazzanti, Manuela; Barthélémy, Philippe; Rottey, Sylvie; Awada, Ahmad; Hanssens, Valérie; Jonge, Natalie De; Rompaey, Luc Van; Fung, Samson Sau-Sing; Michieli, Paolo; Borg, Christophe

doi:10.1200/jco.2016.34.15_suppl.e14016

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Leukocytes and C-met Expression1

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“…This suggests that c-MET may be important in regulation of immunoregulatory processes. Indeed, an abstract from a pre-clinical study of a c-MET targeting therapeutic antibody ARGX-111 indicates that the drug can diminish c-MET positive MDSCs, suggesting a role of this drug in treating c-MET positive tumors and altering c-MET activity of cells in the tumor microenvironment (75).…”

Section: Leukocytes and C-met Expressionmentioning

confidence: 99%

The Emerging Role of the c-MET-HGF Axis in Non-small Cell Lung Cancer Tumor Immunology and Immunotherapy

et al. 2020

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Study of the c-Met-HGF axis in non-small cell lung cancer (NSCLC) has focused on the roles of c-MET signaling in neoplastic epithelial cells and the secretion of its ligand hepatocyte growth factor (HGF) by tumor stromal cells. However, there is increasing evidence that some leukocyte subsets also express c-MET raising the possibility of an immunomodulatory role for this axis. Consequently, the role of the c-MET-HGF axis in immunoncology is an active area of ongoing research. This review summarizes current knowledge of c-MET expression in NSCLC, the prognostic significance of these findings and the mechanisms by which the c-MET-HGF axis might act in NSCLC, focusing on the emerging evidence for an immunoregulatory role.

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Section: Leukocytes and C-met Expressionmentioning

confidence: 99%