Argus II retinal prosthesis system: a review of patient selection criteria, surgical considerations, and post-operative outcomes

Finn, Arthur L.; Grewal, Dilraj S.; Vajzovic, Lejla

doi:10.2147/opth.s137525

Cited by 49 publications

(37 citation statements)

References 29 publications

(41 reference statements)

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“…Not only stem cell and gene therapy but also visual prosthetics such as retinal implants have been developed for the treatment of types of retinal degeneration (RD) like retinitis pigmentosa, choroideremia, and geographic atrophy of age-related macular degeneration [1234]. Although some treatment modalities have shown positive results in vision restoration [1567], to further develop and improve such treatment modalities, experimental larger animal models are inevitably needed, such as those involving pigs, cats, or rabbits exhibiting a selective loss of photoreceptors.…”

Section: Introductionmentioning

confidence: 99%

Development of a Post-vitrectomy Injection of N-methyl-N-nitrosourea as a Localized Retinal Degeneration Rabbit Model

Ahn

Cha

et al. 2019

Exp Neurobiol

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Since genetic models for retinal degeneration (RD) in animals larger than rodents have not been firmly established to date, we sought in the present study to develop a new rabbit model of drug-induced RD. First, intravitreal injection of N-methyl-N-nitrosourea (MNU) without vitrectomy in rabbits was performed with different doses. One month after injection, morphological changes in the retinas were identified with ultra-wide-field color fundus photography (FP) and fundus autofluorescence (AF) imaging as well as spectral-domain optical coherence tomography (OCT). Notably, the degree of RD was not consistently correlated with MNU dose. Then, to check the effects of vitrectomy on MNU-induced RD, the intravitreal injection of MNU after vitrectomy in rabbits was also performed with different doses. In OCT, while there were no significant changes in the retinas for injections up to 0.1 mg (i.e., sham, 0.05 mg, and 0.1 mg), outer retinal atrophy and retinal atrophy of the whole layer were observed with MNU injections of 0.3 mg and 0.5 mg, respectively. With this outcome, 0.2 mg MNU was chosen to be injected into rabbit eyes (n=10) at two weeks after vitrectomy for further study. Six weeks after injection, morphological identification with FP, AF, OCT, and histology clearly showed localized outer RD - clearly bordered non-degenerated and degenerated outer retinal area - in all rabbits. We suggest our post-vitrectomy MNU-induced RD rabbit model could be used as an interim animal model for visual prosthetics before the transition to larger animal models.

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Section: Introductionmentioning

confidence: 99%

Development of a Post-vitrectomy Injection of N-methyl-N-nitrosourea as a Localized Retinal Degeneration Rabbit Model

Ahn

Cha

et al. 2019

Exp Neurobiol

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“…This will increase the degree of miniaturization in electronic implants because there will be no need to use dedicated sensors or other active electronic components. Electronic implants with inductive power supply, such as retinal implants [ 1 , 6 , 7 , 9 ], cochlear implants [ 29 , 30 ], and the hypoglossal nerve stimulator GenioTM (Nyxoah SA, Mont-Saint-Guibert, Belgium) [ 31 ] would be particularly suitable for this purpose.…”

Section: Discussionmentioning

confidence: 99%

“…The electrical stimulation pulses are delivered through wire-bound electrodes, which are susceptible to migration and fracture over time [ 5 ]. Examples include the Argus II epiretinal implantable system [ 1 , 6 ] and the Alpha IMS subretinal implantable system [ 1 , 7 ] where a wire connection through the eye is required to connect the stimulation electrodes to the implantable electronics. Such connections are exposed to mechanical stress, require a more complex surgical procedure and increase the risk of infections.…”

Section: Introductionmentioning

confidence: 99%

Consistent and Efficient Modeling of the Nonlinear Properties of Ferroelectric Materials in Ceramic Capacitors for Frugal Electronic Implants

Olsommer

Ihmig

2020

Sensors

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In recent years, the development of implantable electronics has been driven by the motivation to expand their field of application. The main intention is to implement advanced functionalities while increasing the degree of miniaturization and maintaining reliability. The intrinsic nonlinear properties of the electronic components, to be used anyway, could be utilized to resolve this issue. To master the implementation of functionalities in implantable electronics using the nonlinear properties of its electronic components, simulation models are of utmost importance. In this paper, we present a simulation model that is optimized in terms of consistency, computing time and memory consumption. Three circuit topologies of nonlinear capacitors, including hysteresis losses, are investigated. An inductively coupled measurement setup was realized to validate the calculations. The best results were obtained using the Trapezoid method in ANSYS with a constant step size and a resolution of 500 k points and using the Adams method in Mathcad with a resolution of 50 k points. An inductive coupling factor between 7% and 10% leads to a significant improvement in consistency compared to lower coupling factors. Finally, our results indicate that the nonlinear properties of the voltage rectifier capacitor can be neglected since these do not significantly affect the simulation results.

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“…Despite the clinical application of both neural interface technology [83] and stem-cell therapies, [84] a biohybrid approach for vision restoration has yet to be described to date.…”

Section: Visionmentioning

confidence: 99%

When Bio Meets Technology: Biohybrid Neural Interfaces

et al. 2019

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The development of electronics capable of interfacing with the nervous system is a rapidly advancing field with applications in basic science and clinical translation. Devices containing arrays of electrodes can be used in the study of cells grown in culture or can be implanted into damaged or dysfunctional tissue to restore normal function. While devices are typically designed and used exclusively for one of these two purposes, there have been increasing efforts in developing implantable electrode arrays capable of housing cultured cells, referred to as biohybrid implants. Once implanted, the cells within these implants integrate into the tissue, serving as a mediator of the electrode–tissue interface. This biological component offers unique advantages to these implant designs, providing better tissue integration and potentially long‐term stability. Herein, an overview of current research into biohybrid devices, as well as the historical background that led to their development are provided, based on the host anatomical location for which they are designed (CNS, PNS, or special senses). Finally, a summary of the key challenges of this technology and potential future research directions are presented.

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Argus II retinal prosthesis system: a review of patient selection criteria, surgical considerations, and post-operative outcomes

Cited by 49 publications

References 29 publications

Development of a Post-vitrectomy Injection of N-methyl-N-nitrosourea as a Localized Retinal Degeneration Rabbit Model

Development of a Post-vitrectomy Injection of N-methyl-N-nitrosourea as a Localized Retinal Degeneration Rabbit Model

Consistent and Efficient Modeling of the Nonlinear Properties of Ferroelectric Materials in Ceramic Capacitors for Frugal Electronic Implants

When Bio Meets Technology: Biohybrid Neural Interfaces

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