Arguments to Support a Viral Origin of Oral Squamous Cell Carcinoma in Non-Smoker and Non-Drinker Patients

Foy, Jean‐Philippe; Bertolus, Chloé; Boutolleau, David; Agut, Henri; Gessain, Antoine; Herceg, Zdenko; Saintigny, Pierre

doi:10.3389/fonc.2020.00822

Cited by 24 publications

(27 citation statements)

References 62 publications

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“…Because viral genome integration has not been detected in non-smoking and non-drinking OSCC, a "hit and run" viral mechanism involving epigenome deregulation could therefore play a key role at early steps of oral carcinogenesis in this population of patients. [18] In our cohort, males OSCC were more likely to occur in buccal (38.4%) and tongue (35.3%) locations. The buccal mucosa is the most affected site in people with BQ chewing history due to frequent mucosa irritation.…”

Section: Discussionmentioning

confidence: 59%

Female Versus Male Oral Cavity Cancer: is There a Difference?

Lee¹,

Chien²,

Young³

et al. 2020

Preprint

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Objectives: Oral cavity squamous cell carcinoma (OSCC) is a leading cause of death in Taiwan, and most of the patients are male. Little is known about the differences in risk factors, cancer characteristics and treatment outcomes in female patients. The study aim is to investigate the clinicopathological and outcome differences between gender in patients affected by oral cancer in Taiwan.Methods: This is a retrospective study based on data obtained between 1995 and 2019. A total of 2,046 patients were recruited for analysis. Cancer characteristics, risk factors and treatment outcomes in patients with oral cancer between genders were collected. Results: Female patients represented the 6.7% of the entire cohort of study. Females were diagnosed at an older age and at an earlier local stage compared to male patients (p < 0.001). The female patients were less exposed to cigarette, alcohol, and betel-nut (BQ) (all p-values < 0.001). Tongue (55.1%) was the most frequent subsite involved in the female group, while buccal (38.4%) and tongue (35.3%) were more likely (p < 0.001) to be associated with male gender. In tongue cancer subgroup, female patients presented less frequently extra-nodal extension compared with male patients (p = 0.040). During the follow-up period, there was no significant difference in recurrence and overall deaths between genders.Conclusion:In Taiwan, the male to female ratio in OSCC is 14:1. The tumor subsite distribution, environment exposure and stage distribution are different between females and male. There are no differences in term of survival between female and male OSCC patients.

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Section: Discussionmentioning

confidence: 59%

Female Versus Male Oral Cavity Cancer: is There a Difference?

Lee¹,

Chien²,

Young³

et al. 2020

Preprint

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“…Though the etiologic hypothesis of an oncovirus influence has been ascribed severally to NSND OCSCC tumorigenesis, 3,5,38 we found that specific investigations into viral detection and causation from the reviewed reports do not directly support this theory presently. Also, oral cancer predisposing factors, such as family history, poor oral hygiene, chronic periodontitis, and low educational attainment, were observed to take higher precedence in NSND OCSCC as associated factors.…”

Section: Discussionmentioning

confidence: 66%

“Fact or fiction?”: Oral cavity cancer in nonsmoking, nonalcohol drinking patients as a distinct entity—Scoping review

Adeoye

Tan

et al. 2021

Head & Neck

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Oral cavity cancer is often described as a lifestyle‐related malignancy due to its strong associations with habitual factors, including tobacco use, heavy alcohol consumption, and betel nut chewing. However, patients with no genetically predisposing conditions who do not indulge in these risk habits are still being encountered, albeit less commonly. The aim of this review is to summarize contemporaneous reports on these nonsmoking, nonalcohol drinking (NSND) patients. We performed database searching to identify relevant studies from January 1, 2000 to March 31, 2021. Twenty‐six articles from 20 studies were included in this study. We found that these individuals were mostly females in their eighth decade with tumors involving the tongue and gingivobuccal mucosa. This review also observed that these patients were likely diagnosed with early stage tumors with overexpression of programmed death‐ligand 1 (PD‐L1) and increased intensity of tumor infiltrating lymphocytes. Treatment response and disease‐specific prognosis were largely comparable between NSND and smoking/drinking patients.

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“…The current hypothesis about carcinogenesis of oral SCC consists of an accumulation of genetic mutations in the oral epithelial cells, which may be favored by some risk factors such as excessive alcohol drinking and tobacco smoking [3,10]. However, there is an emerging population of patients with oral malignant tumors, but without exposure or with slight exposure to these two common risk factors, especially young and elderly women [10,11] [11]. In this case, there was no history of alcohol drinking and tobacco smoking.…”

Section: Figure6 Preoperative Histopathological Image Of Keratinizinmentioning

confidence: 99%

Keratinizing Squamous Cell Carcinoma of the Palate in Clinically Negative Neck: Case Report and Review

Lubamba

Guan

et al. 2021

ijmsci

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Background: The Squamous cell carcinoma of the palate is rare; women are more affected than men. This study aimed to discuss the etiology, diagnostic modalities, prognosis factors, and treatment strategies. Case: A 49-year-old woman was admitted to our department in 2019 with a chief complaint of a hard and painful mass on the right palate. The Clinical assessment revealed a palatal tumor extended to 3/4 of hard palate and part of the soft palate, with hard consistency, no mobility, cauliflower-like surface partly covered by a white pseudo-membrane, dark red-colored, and clinically negative neck. 3D CT scan of palate and maxilla revealed malignant lesion features, Cervical MRI and Chest CT revealed enlarged lymph nodes. The histopathological assessment diagnosed keratinizing squamous cell carcinoma of the right palate. Resection of the tumor and Reconstructive surgery were performed. The postoperative outcomes were simple. Conclusion: Hepatitis B virus, local chronic inflammation were the risk factors incriminated in this case. The prognosis factors such as patient age, tumor size, lymph node involvement, bone invasion, and pathological grade influence the treatment and survival. Selective neck dissection, Ablative surgery, and Reconstruction with Submental island flap represented our management strategy for keratinizing squamous cell carcinoma of the palate.

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Arguments to Support a Viral Origin of Oral Squamous Cell Carcinoma in Non-Smoker and Non-Drinker Patients

Cited by 24 publications

References 62 publications

Female Versus Male Oral Cavity Cancer: is There a Difference?

Female Versus Male Oral Cavity Cancer: is There a Difference?

“Fact or fiction?”: Oral cavity cancer in nonsmoking, nonalcohol drinking patients as a distinct entity—Scoping review

Keratinizing Squamous Cell Carcinoma of the Palate in Clinically Negative Neck: Case Report and Review

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