Arginine Vasopressin Secretion in Thyroidectomized Sheep

Fetal Neurohypophyseal Arginine Vasopressin and Arginine Vasotocin in Man and Sheep

“…A V T also has bccn measured in the cerebral spinal fluid of adult mammals, including man (7,15,17). w e have recently reported RIA systems for measurement of AVP (24) and AVT, using a differential antiserum protocol (21). The present study reports results applying this nlcthod to qualititation of AVP and AVT in early gestational age human fetal pituitary glands and late gestational age ovinc fetal pituitary glands.…”

“…AVP has been quantitated within the fetal niamnlaliarl pituitary ( I , 2, 26) and kinetic studies have suggesteel autonomous fetal secretion at rates greatly exceeding maternal procluction (23). Recent reports have suggcstcd the presence of the nonapepticle A V T in the fetal mammalian pituitary (19,20,26) rts well as in the mammalian pineal gland ( 6 , 10, 14, 16).…”

“…Synthetic AVP ancl AVT a e r c iodinated, using a modification of the method of Hunter ancl Greenwood (24). Assay procedures werc carried out as described earlier (21,23). and bourid ant1 free hormones were scparaterl exclusively by the double antibody nicthod (13).…”

Hyponatremia with Increased Plasma Antidiuretic Hormone in a Case of Hypothyroidism.

“…In this case, there is some possibility for volume depletion due to the decrease in the hematocrit after treatment, it is unlikely, however, that the patient was in a severe hypovolemic state, as judged by the suppressed levels of both plasma renin activity and plasma aldosterone concentration. Deficiency of the thyroid hormone itself may also affect the high levels of ADHin case of severe hypothyroidism (15). However, this patient was in a state of mild primary hypothyroidism on the basis of the slightly increased TSH level.…”

Effects of an Acute Water Load on Plasma ANP and AVP, and Renal Water Handling in Hypothyroidism: Comparison of Before and After L-Thyroxine Treatment.

“…So far, several potential mechanisms have been proposed to explain these abnormalities, but the exact mechanism is still controversial. Enhanced arginine vasopressin (AVP) release has been reported in hypothyroidism [2,3], but it was also found that AVP might not participate directly in the impaired water and electrolyte metabolism, but rather that renal dysfunction plays an essential Received: July 2, 1993 Accepted: October 27, 1993 Correspondence to: Dr. Kozo OTA, The Second Department of Internal Medicine, Tohoku University School of Medicine, 1-1 Seiryocho, Aobaku, Sendai 980, Japan *Present address : Yamagata Municipal Hospital Saiseikan, Yamagata, Japan role in the impairment in hypothyroidism [1, 4--6]. On the other hand, plasma atrial natriuretic peptide (ANP), eliciting natriuresis and diuresis, has been reported to decrease in hypothyroid patients [7,8], reminiscent of impaired handling of renal electrolytes.…”