Arginine metabolic control of airway inflammation

Asosingh, Kewal; Lauruschkat, Chris D.; Alemagno, Mario; Frimel, Matthew; Wanner, Nicholas; Weiss, Kelly; Kessler, Sean P.; Meyers, Deborah A.; Bennett, Carole; Xu, Weiling; Erzurum, Serpil C.

doi:10.1172/jci.insight.127801

Cited by 33 publications

(29 citation statements)

References 64 publications

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“…with ARG2 variants and that the arginine metabolome is affected by environmental factors such as traffic pollution, the original hypothesis may have been misguided (27,28). Despite the negative result overall, we did identify some interesting predictive baseline metabolic biomarkers that have implications for proper patient selection for l-arginine therapy.…”

Section: I N I C a L M E D I C I N Ementioning

confidence: 68%

l-Arginine supplementation in severe asthma

Liao¹,

Showalter²,

Linderholm³

et al. 2020

JCI Insight

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Section: I N I C a L M E D I C I N Ementioning

confidence: 68%

l-Arginine supplementation in severe asthma

Liao¹,

Showalter²,

Linderholm³

et al. 2020

JCI Insight

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“…Arginine is the common substrate of inducible nitric oxide synthase (iNOS) and arginase‐2 (ARG2). Arginine metabolism via both iNOS and ARG2 is involved in the regulation of airway inflammation (29, 30). Glutamate and methionine are glucogenic amino acid and can convert to α‐ketoglutaric acid in order to feed the citric acid cycle.…”

Section: Discussionmentioning

confidence: 99%

Serum metabolomic profiling reveals important difference between infants with and without subsequent recurrent wheezing in later childhood after RSV bronchiolitis

Zhang

Peng

Zhang

et al. 2020

APMIS

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We aimed to use serum metabolomics to discriminate infants with severe respiratory syncytial virus (RSV) bronchiolitis who later developed subsequent recurrent wheezing from those who did not and to investigate the relationship between serum metabolome and host immune responses with regard to the subsequent development of recurrent wheezing. Fifty‐one infants who were hospitalized during an initial episode of severe RSV bronchiolitis at 6 months of age or less were included and followed for up to the age of 3 years. Of them, 24 developed subsequent recurrent wheezing and 27 did not. Untargeted serum metabolomics was performed by ultraperformance liquid chromatography coupled with high‐resolution mass spectrometry (UPLC‐MS/MS). Cytokines were measured by multiplex immunoassay. Difference in serum metabolomic profiles was observed between infants who developed recurrent wheezing and those who did not. L‐lactic acid level was significantly higher in infants with recurrent wheezing than those without. Pyrimidine metabolism, glycerophospholipid metabolism, and arginine biosynthesis were identified as the most significant changed pathways between the two groups. Moreover, L‐lactic acid level was positively associated with serum CXCL8 level. This exploratory study showed that differential serum metabolic signatures during severe RSV bronchiolitis in early infancy were associated with the development of subsequent recurrent wheezing in later childhood.

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“…It is possible that decreasing arginase activity could be a promising target in treating inflammatory airway diseases. It has recently been reported that arginine metabolism controls neutrophilic and eosinophilic pathways which regulate inflammation severity [81]. Moreover, arginase I expression, more than arginase II, was induced in Th2 cytokine‐mediated lung inflammation and allergen‐challenged lungs in mice [82–84].…”

Section: Discussionmentioning

confidence: 99%

Leonurus sibiricus root extracts decrease airway remodeling markers expression in fibroblasts

Wieczfińska

Sitarek

Kowalczyk

et al. 2020

Clinical and Experimental Immunology

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Airway remodeling is a complex process, and controlling it appears to be a key for halting the progression of asthma and other obstructive lung diseases. The aim of this study was to evaluate the anti‐remodeling properties of extracts from transformed and transgenic L. sibiricus roots with overexpression of AtPAP1 transcriptional factor. Our study shows for the first time that transformed AtPAP1 TR extract from L. sibiricus root may affect the remodeling process.

show abstract

Arginine metabolic control of airway inflammation

Cited by 33 publications

References 64 publications

l-Arginine supplementation in severe asthma

l-Arginine supplementation in severe asthma

Serum metabolomic profiling reveals important difference between infants with and without subsequent recurrent wheezing in later childhood after RSV bronchiolitis

Leonurus sibiricus root extracts decrease airway remodeling markers expression in fibroblasts

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