Arginine-Glycine-Aspartic Acid-Conjugated Dendrimer-Modified Quantum Dots for Targeting and Imaging Melanoma

Li, Zhiming; Huang, Peng; Lin, Jing; He, Rong; Liu, Bing; Zhang, Xiaomin; Yang, Sen; Xi, Peng; Zhang, Xuejun; Ren, Qiushi; Cui, Daxiang

doi:10.1166/jnn.2010.2217

Cited by 44 publications

(16 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…QDs are fluorescent NPs that are increasingly being utilized in commercial and technological applications (Koleilat et al, 2008; Lee et al, 2010; Li et al, 2010; Wu et al, 2004). Therefore, understanding how QDs interact with skin is a primary concern.…”

Section: Introductionmentioning

confidence: 99%

Quantification of quantum dot murine skin penetration with UVR barrier impairment

et al. 2013

View full text Add to dashboard Cite

Ultraviolet radiation (UVR) skin exposure is a common exogenous insult that can alter skin barrier and immune functions. With the growing presence of nanoparticles (NPs) in consumer goods and technological applications the potential for NPs to contact UVR exposed skin is increasing. Therefore it is important to understand the effect of UVR on NP skin penetration and potential for systemic translocation. Previous studies qualitatively showed that UVR skin exposure can increase the penetration of NPs below the stratum corneum. In the present work, an in vivo mouse model was used to quantitatively examine the skin penetration of carboxylated (CdSe/ZnS, core/shell) quantum dots (QDs) through intact and UVR barrier disrupted murine skin by organ Cd mass analysis. Transepidermal water loss was used to measure the magnitude of the skin barrier defect as a function of dose and time post UVR exposure. QDs were applied to mice 3-4 days post UVR exposure at the peak of the skin barrier disruption. Our results reveal unexpected trends that suggest these negative charged QDs can penetrate barrier intact skin and that penetration and systemic transport depends on the QD application time post UVR exposure. The effect of UVR on skin resident dendritic cells and their role in the systemic translocation of these QDs are described. Our results suggest that NP skin penetration and translocation may depend on the specific barrier insult and the inflammatory status of the skin.

show abstract

Section: Introductionmentioning

confidence: 99%

Quantification of quantum dot murine skin penetration with UVR barrier impairment

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Most chemotherapeutics are administered systemically and are cytotoxic to healthy cells; therefore cancer patients must endure considerable morbidity. Nanomedicine seeks to engineer nanoparticles to image (Schmieder et al, 2005; Boles et al, 2010; Benezra et al, 2011; Li et al, 2010) and selectively deliver drugs (Camerin et al, 2010; Yao et al, 2011) or small-interfering RNA (Davis et al, 2010; Chen et al, 2010; Chen et al, 2010a) specifically to melanoma cells. Many potential drugs fail clinically due to insolubility.…”

Section: Nanoparticle Based Therapeuticsmentioning

confidence: 99%

Applications of Nanotechnology in Dermatology

DeLouise

2012

Journal of Investigative Dermatology

170

View full text Add to dashboard Cite

What are nanoparticles and why are they important in dermatology? These questions are addressed by highlighting recent developments in the nanotechnology field that have increased the potential for intentional and unintended nanoparticle skin exposure. The role of environmental factors in the interaction of nanoparticles with skin and the potential mechanisms by which nanoparticles may influence skin response to environmental factors are discussed. Trends emerging from recent literature suggest that the positive benefit of engineered nanoparticles for use in cosmetics and as tools for understanding skin biology and curing skin disease, out weigh potential toxicity concerns. Discoveries reported in this journal are highlighted. This review begins with a general introduction to the field of nanotechnology and nanomedicine. This is followed by a discussion of the current state of understanding of nanoparticle skin penetration and their use in three different therapeutic applications. Challenges that must be overcome to derive clinical benefit from the application of nanotechnology to skin are discussed last, providing perspective on the significant opportunity that exists for future studies in investigative dermatology.

show abstract

“…In other applications, dendrimers can be used to modify other nanodevices, such as carbon nanotubes [92][93][94][95], gold nanoparticles [84,[96][97][98][99][100] and nanorods [101], magnetic particles [102,103] and quantum dots [104][105][106] (figure 2d ). Modification by bioactive dendrimer conjugates can particularly serve to improve biocompatibility, enhance solubility and provide a mechanism for tissue-or cell-specific targeting.…”

Section: General Applications Of Dendrimer Materials In Drug Deliverymentioning

confidence: 99%

Peptide- and saccharide-conjugated dendrimers for targeted drug delivery: a concise review

et al. 2012

View full text Add to dashboard Cite

Dendrimers comprise a category of branched materials with diverse functions that can be constructed with defined architectural and chemical structures. When decorated with bioactive ligands made of peptides and saccharides through peripheral chemical groups, dendrimer conjugates are turned into nanomaterials possessing attractive binding properties with the cognate receptors. At the cellular level, bioactive dendrimer conjugates can interact with cells with avidity and selectivity, and this function has particularly stimulated interests in investigating the targeting potential of dendrimer materials for the design of drug delivery systems. In addition, bioactive dendrimer conjugates have so far been studied for their versatile capabilities to enhance stability, solubility and absorption of various types of therapeutics. This review presents a brief discussion on three aspects of the recent studies to use peptide-and saccharide-conjugated dendrimers for drug delivery: (i) synthesis methods, (ii) cell-and tissue-targeting properties and (iii) applications of conjugated dendrimers in drug delivery nanodevices. With more studies to elucidate the structure-function relationship of ligand-dendrimer conjugates in transporting drugs, the conjugated dendrimers hold promise to facilitate targeted delivery and improve drug efficacy for discovery and development of modern pharmaceutics.

show abstract

Arginine-Glycine-Aspartic Acid-Conjugated Dendrimer-Modified Quantum Dots for Targeting and Imaging Melanoma

Cited by 44 publications

References 19 publications

Quantification of quantum dot murine skin penetration with UVR barrier impairment

Quantification of quantum dot murine skin penetration with UVR barrier impairment

Applications of Nanotechnology in Dermatology

Peptide- and saccharide-conjugated dendrimers for targeted drug delivery: a concise review

Contact Info

Product

Resources

About