Arginine—Dual roles as an onconutrient and immunonutrient

Albaugh, Vance L.; Pinzon-Guzman, Carolina; Barbul, Adrian

doi:10.1002/jso.24490

Cited by 103 publications

(78 citation statements)

References 101 publications

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“…Next to NO synthesis, L-arginine serves as the substrate for the enzymatic transformation of agmatine, creatine and urea in the human body [4, 5]. As the only precursor and nitrogen donor for nitric oxide (NO), L-arginine plays a central role in the form of a messenger in several physiological and pathophysiological processes [6-9]. Thus, L-arginine can be considered as a signaling molecule, which is responsible for the maintenance of essential cellular functions e.g.…”

Section: Introductionmentioning

confidence: 99%

Activation of Secretagogue Independent Gastric Acid Secretion via Endothelial Nitric Oxide Synthase Stimulation in Rats

Kitay

Link

Geibel

2017

Cell Physiol Biochem

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Background/Aims: L-arginine is an important mediator of cell division, wound healing, and immune function. It can be transformed by the nitric oxide synthase (NOS) to nitric oxide (NO), an important cell signaling molecule. Recent studies from our laboratory demonstrate specific effects of L-arginine (10mM) exposure on gastric acid secretion in rat parietal cells. Methods: Studies were performed with isolated gastric glands and the pH sensitive dye BCECF-AM +/- L-arginine to examine its effects on acid secretion. The direct NO-donor diethylamine NONOate sodium salt hydrate, was also used while monitoring intracellular pH. The specific inhibitor of the intracellular NO signal cascade ODQ was also used. Results: We found that gastric proton extrusion was activated with application of L-arginine (10mM), in a separate series when L-arginine (10mM) + L-NAME (30µM) were added there was no acid secretion. Addition of the NO-donor diethylamine NONOate sodium salt hydrate (10µM) also induced acid secretion. When the selective sGC-inhibitor ODQ was added with NONOate we did not observe acid secretion. Conclusion: We conclude that L-arginine is a novel secretagogue, which can mediate gastric acid secretion. Furthermore, the intake of L-arginine causes direct activation of the H⁺, K⁺ ATPase and increased proton extrusion from parietal cells resulting in the increased risk for acid-related diseases. The NO/sGC/cGMP pathway has never been described as a possible intracellular mechanism for H⁺, K⁺ ATPase activation before and presents a completely new scientific finding. Moreover, our studies demonstrate a novel role for L-NAME to effectively eliminate NOS induced acid secretion and thereby reducing the risk for L-arginine inducible ulcer disease.

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Section: Introductionmentioning

confidence: 99%

Activation of Secretagogue Independent Gastric Acid Secretion via Endothelial Nitric Oxide Synthase Stimulation in Rats

Kitay

Link

Geibel

2017

Cell Physiol Biochem

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“…Given its vital role in cell growth, proliferation and immune responses. Arginine has been investigated as a potential target for cancer treatments [34]. Glycine is a nonessential amino acid because it can be synthesized by the body.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Mutations of the MED12 and CYP17A1 Genes in Mammary Fibroadenomas in Senegalese Women

Rokhaya¹,

Noël²,

Bineta³

et al. 2020

IJGG

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Fibroadenoma is the most common benign breast tumor in women under 30 years. This study aimed to contribute to the knowledge of the genetic factors involved in the occurrence and progression of mammary fibroadenomas. MED12 and CYP17A1 were sequenced in fibroadenomas and blood in 43 Senegalese women. The Alamut-visual software, which includes the pathogenicity prediction software SIFT, Polyphen2 and MutationTaster, was used to search for mutations. DnaSP version 5.10.01, MEGA version 7.0.14 and Arlequin version 3.5.1.3 were used to determine phylogenetic parameters including indices of genetic variability and diversity and genetic differentiation parameters. A deletion in the poly-A tail of MED12 was identified in our study population. An alteration of Methionine (M1) was observed on exon 1 of CYP17A1. Our results also show that most of the variants found on exon 2 of MED12 and exon 1 of CYP17A1 have the probability of causing the appearance of breast fibroadenomas according by the three pathogenicity prediction software. We found 23 new variants on the MED12 gene and 109 new variants on the CYP17A1 gene. The amino acid frequency distribution between blood and fibroadenomas shows a statistically significant difference in Glycine, Arginine and Valine for MED12 and Cysteine, Phenylalanine, Histidine, Asparagine, Arginine, Tryptophan and Tyrosine for CYP17A1. In addition the selection test shows that codon 20 of exon 1 of CYP17A1 which codes for Arginine (p.20Arg) is under positive selection in mammary fibroadenomas. Genetic differentiation parameters show a clear difference between blood and breast fibroadenomas. These results show for the first time the involvement of the CYP17A1 gene in breast fibroadenomas and confirm the involvement of MED12. Codon 20 of exon 1 of CYP17A1 being under positive selection could be used as a biomarker in breast fibroadenomas.

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“…In fact, the presence of arginine is needed by tumoral cells for growth, and that circumstance has promoted the concept of using diets in which arginine deprivation could be beneficial for patients [48]. However, arginine has also been reported to represent a critical component of body systems for keeping in check abnormal cells such as tumor ones [49]. Thus, arginine is an important component of immune surveillance (Figure 1).…”

Section: Argininementioning

confidence: 99%

“…In fact, nitric oxide may play a role in tumor cell cytotoxicity by increasing the antitumoral action of several cells of the immune system such as macrophages, natural killer cells, or cytotoxic T-cells [52,53]. As arginine has been reported to be necessary for both cancer growth and normal immune function, several clinical trials are analyzing the role of arginine deprivation versus supplementation in patients with cancer [49].…”

Section: Argininementioning

confidence: 99%

Antitumoral Properties of the Nutritional Supplement Ocoxin Oral Solution: A Comprehensive Review

2020

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Ocoxin Oral Solution (OOS) is a nutritional supplement whose formulation includes several plant extracts and natural products with demonstrated antitumoral properties. This review summarizes the antitumoral action of the different constituents of OOS. The action of this formulation on different preclinical models as well as clinical trials is reviewed, paying special attention to the mechanism of action and quality of life improvement properties of this nutritional supplement. Molecularly, its mode of action includes a double edge role on tumor biology, that involves a slowdown in cell proliferation accompanied by cell death induction. Given the safety and good tolerability of OOS, and its potentiation of the antitumoral effect of other standard of care drugs, OOS may be used in the oncology clinic in combination with conventional therapies.

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Arginine—Dual roles as an onconutrient and immunonutrient

Cited by 103 publications

References 101 publications

Activation of Secretagogue Independent Gastric Acid Secretion via Endothelial Nitric Oxide Synthase Stimulation in Rats

Activation of Secretagogue Independent Gastric Acid Secretion via Endothelial Nitric Oxide Synthase Stimulation in Rats

Prevalence of Mutations of the MED12 and CYP17A1 Genes in Mammary Fibroadenomas in Senegalese Women

Antitumoral Properties of the Nutritional Supplement Ocoxin Oral Solution: A Comprehensive Review

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