Arginine deficiency measured by global arginine bioavailability ratio in patients with acute coronary syndrome

Miyazaki, Kôji; Masaki, Nobuyuki; Adachi, Takeshi

doi:10.30548/vascfail.2.2_80

Cited by 3 publications

(4 citation statements)

References 39 publications

(44 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We recently investigated GABR in the emergency setting of acute coronary syndrome (ACS). GABR was significantly decreased in the ACS group compared with the non-ACS group (i.e., stable patients undergoing coronary angiography), but we could not find any significant difference in GABR according to the presence or absence of CAD in the non-ACS group 14) . In that study, patients in the non-ACS group who did not have coronary stenosis had undergone coronary angiography for reasons such as symptoms or signs compatible with coronary ischemia.…”

Section: Introductioncontrasting

confidence: 75%

Decreased arginine bioavailability in patients with coronary artery disease in an outpatient setting

2020

Self Cite

View full text Add to dashboard Cite

Background: The metabolic profile of arginine is a potential biomarker for coronary artery disease (CAD). The global arginine bioavailability ratio (GABR), the ratio of the serum arginine level to the sum of the serum levels of its metabolites [L-arginine/(L-citrulline + L-ornithine)], has been reported as a marker of arginine bioavailability. The association between GABR and CAD was examined in an outpatient setting. Methods and Results: Serum levels of arginine and its related metabolites were measured in 234 cardiovascular outpatients (185 male, 49 female; age, 66 12 years). The patients were divided into two groups: 118 (50%) patients with CAD [CAD(+)] and 116 (50%) patients without CAD [CAD(−)]. There were significant differences in the serum concentrations for the CAD(+) vs. CAD(−) groups, respectively, as follows: Larginine (86 23 μmol/L vs. 78 22 μmol/L; p=0.003), L-citrulline (138 60 μmol/L vs. 115 65 μmol/L; p= 0.005), L-ornithine (64 28 μmol/L vs. 50 29 μmol/L; p<0.001), asymmetric dimethyl arginine (0.57 0.18 μmol/L vs. 0.50 0.18 μmol/L; p=0.004), the ratio of L-arginine (Arg) to L-citrulline (Cit) (0.70 0.29 vs. 0.92 0.61, p= 0.001), and GABR (0.46 0.15 vs. 0.55 0.24, p=0.001). In multivariate logistic regression analysis adjusted for clinical variables, the ratio of Arg/Cit and GABR were significantly associated with CAD. Conclusions: Our results suggest that the metabolic profile of arginine, especially Arg/Cit and GABR, has independent predictive value for the presence of CAD over traditional risk factors in an outpatient setting.

show abstract

Section: Introductioncontrasting

confidence: 75%

Decreased arginine bioavailability in patients with coronary artery disease in an outpatient setting

2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Patients with cardiogenic shock due to acute myocardial infarction (AMI) have been reported to have a lower GABR compared with patients with stable CAD 25) . We also previously reported that the GABR is lower in patients with acute coronary syndrome (ACS) [26][27][28] . Thus, many cross-sectional studies have examined amino acid profiles; however, long-term mortality according to the amino acid profile has not been fully investigated.…”

Section: Coronary Risk Factorsmentioning

confidence: 83%

“…Increased arginase activity in endothelial cells may lead to endothelial dysfunction by decreasing the concentration of l-arginine available for NO production. Another possibility may be the decreased bioavailability of arginine by metabolites of studies, arteriosclerosis, CAD, and ACS were found to be strongly associated with the bioavailability of l-arginine 26,27,[47][48][49] . Decreased l-arginine bioavailability is likewise associated with obesity, insulin resistance, catabolic metabolites, l-ornithine and l-citrulline, during urea synthesis, a low l-arginine/l-ornithine ratio indicates decreased l-arginine bioavailability with increased arginase activity.…”

Section: Cox Regression Analysis For the Primary And Secondary Endpointsmentioning

confidence: 99%

A Low Arginine/Ornithine Ratio is Associated with Long-Term Cardiovascular Mortality

Ishinoda

Masaki

Hitomi

et al. 2023

JAT

Self Cite

View full text Add to dashboard Cite

Aims:The long-term prognostic value of the bioavailability of l-arginine, an important source of nitric oxide for the maintenance of vascular endothelial function, has not been investigated fully. We therefore investigated the relationship between amino acid profile and long-term prognosis in patients with a history of standby coronary angiography. Methods:We measured the serum concentrations of l-arginine, l-citrulline, and l-ornithine by high-speed liquid chromatography. We examined the relationship between the l-arginine/l-ornithine ratio and the incidence of all-cause death, cardiovascular death, and major adverse cardiovascular events (MACEs) in 262 patients (202 men and 60 women, age 65±13 years) who underwent coronary angiography over a period of ≤ 10 years.Results: During the observation period of 5.5±3.2 years, 31 (12%) patients died, including 20 (8%) of cardiovascular death, while 32 (12%) had MACEs. Cox regression analysis revealed that l-arginine/l-ornithine ratio was associated with an increased risk for all-cause death (unadjusted hazard ratio, 95% confidence interval) (0.940, 0.888-0.995) and cardiovascular death (0.895, 0.821-0.965) (p＜0.05 for all). In a mod el adjusted for age, sex, hypertension, hyperlipidemia, diabetes, current smoking, renal function, and log10-transformed brain natriuretic peptide level, cardiovascular death (0.911, 0.839-0.990, p=0.028) retained an association with a low l-arginine/ l-ornithine ratio. When the patients were grouped according to an l-arginine/l-ornithine ratio of 1.16, the lower l-arginine/l-ornithine ratio group had significantly higher incidence of all-cause death, cardiovascular death, and MACEs. Conclusion:A low l-arginine/l-ornithine ratio may be associated with increased 10-year cardiac mortality.

show abstract

“…The activation of the urea cycle and inducible NO synthase could increase these metabolites [ 28 ]. Increases in the ornithine/arginine ratio or a decrease in GABR (Arg/Cit+Orn) were associated with cardiovascular events [ 29 , 30 ], which were observed in HFHSD-LE2KO. The deterioration in HST and abnormal arginine metabolism may contribute to cardiovascular risk and diseases.…”

Section: Discussionmentioning

confidence: 99%

Metabolic Remodeling with Hepatosteatosis Induced Vascular Oxidative Stress in Hepatic ERK2 Deficiency Mice with High Fat Diets

Kujiraoka

Kagami

Kimura

et al. 2022

IJMS

Self Cite

View full text Add to dashboard Cite

We previously demonstrated the marked hepatosteatosis and endothelial dysfunction in hepatocyte-specific ERK2 knockout mice (LE2KO) with a high-fat/high-sucrose diet (HFHSD), but detailed metabolic changes and the characteristics in insulin-sensitive organs were not tested. This study aimed to characterize metabolic remodeling with changes in insulin-sensitive organs, which could induce endothelial dysfunction in HFHSD-LE2KO. The serum glucose and fatty acid (FA) were modestly higher in HFHSD-LE2KO than HFHSD-Control. FA synthesis genes were up-regulated, which was associated with the decreased phosphorylation of AMPK and ACC, and with the up-regulation of SREBP-1 in the liver from HFHSD-LE2KO. In FA and amino acids fraction analysis, arachidonic acid/eicosapentaenoic acid ratio, L-ornithine/arginine ratio, asymmetric dimethylarginine and homocysteine levels were elevated in HFHSD-LE2KO. Insulin-induced phosphorylation of AKT was blunted in skeletal muscle. Serum leptin and IL-1β were elevated, and serum adiponectin was decreased with the enlargement of epididymal adipocytes. Finally, the enhanced superoxide levels in the aorta, which were blunted with CCCP, apocynin, and tempol, were observed in HFHSD-LE2KO. A pre-incubation of aortic rings with tempol improved endothelial dysfunction in HFHSD-LE2KO. HFHSD-LE2KO revealed an acceleration of FA synthesis in the liver leading to insulin resistance in skeletal muscle and the enlargement of visceral adipocytes. Global metabolic remodeling such as changes in arginine metabolism, ω3/ω6 ratio, and adipocytokines, could affect the vascular oxidative stress and endothelial dysfunction in HFHSD-LE2KO.

show abstract

Arginine deficiency measured by global arginine bioavailability ratio in patients with acute coronary syndrome

Cited by 3 publications

References 39 publications

Decreased arginine bioavailability in patients with coronary artery disease in an outpatient setting

Decreased arginine bioavailability in patients with coronary artery disease in an outpatient setting

A Low Arginine/Ornithine Ratio is Associated with Long-Term Cardiovascular Mortality

Metabolic Remodeling with Hepatosteatosis Induced Vascular Oxidative Stress in Hepatic ERK2 Deficiency Mice with High Fat Diets

Contact Info

Product

Resources

About