Arginase Inhibitory, Antioxidant Activity, Total Phenolic Content and Total Flavonoid Content of Ethyl Acetate Extract of Caesalpiniaturtuosa Roxb Stem Bark

Atikasari, Nadilla N; Hanafi, Muhammad; Elya, Berna

doi:10.5530/pj.2020.12.34

2020

DOI: 10.5530/pj.2020.12.34

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Arginase Inhibitory, Antioxidant Activity, Total Phenolic Content and Total Flavonoid Content of Ethyl Acetate Extract of Caesalpiniaturtuosa Roxb Stem Bark

Nadilla N Atikasari¹,

Muhammad Hanafi²,

Berna Elya³

Abstract: Objective: The purpose of this study is to investigate arginase inhibition, antioxidant activity, total phenolic content and total flavonoid content of ethyl acetate extract of Caesalpiniaturtuosa Roxb. Material and method: stem bark of Caesalpiniaturtuosa Roxb was extracted using hexane, ethyl acetate and methanol subsequently. The ethyl acetate extract was fractioned. Then, the fractions were subjected to arginase inhibition, antioxidant activity, total phenolic content and total flavonoid assay. Correlation… Show more

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Cited by 6 publications

References 24 publications

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Phytochemical, antioxidant, anti-stress and cerebroprotective activity of ethanolic extract of stem of Sarcostemma acidum

Marasani

Dugasani²,

Kilari

2021

RJPT

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The current study was designed to assess the phytochemical, antioxidant, anti-stress and cerebroprotective activities of ethanolic extract of stem of Sarcostemma acidum (EESA). The stem of Sarcostemma acidum was collected and extracted with 70% ethanol. The ethanolic extract was subjected to phytochemical screening (Chemical and HPTLC), antioxidant (in-vitro), anti-stress (Mice model) and cerebroprotective activities (Cerebral ischemia model). EESA showed presence of flavonoids as primary phytoconstituents. EESA significantly reduced the immobility period in tail suspension trial and swimming endurance trial. EESA significantly reduced the TBARS levels (21.45±0.56; p<0.01) and augmented tissue antioxidants in cerebral ischemia model. The levels of MOA-A were reduced in the EESA treated animals (54.1±0.2; p<0.001) and cortisol levels also reduced in EESA treated animals (45.1±1.6; p<0.001). Histopathology also supported the biochemical parameters. The EESA effect was compared with reference standard diazepam and Ashwagandha. EESA showed significant antioxidant, anti-stress and cerebroprotective activities and the protective effect might be due to presence of flavonoids as phytoconstituents.

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Phytochemical, antioxidant, anti-stress and cerebroprotective activity of ethanolic extract of stem of Sarcostemma acidum

Marasani

Dugasani²,

Kilari

2021

RJPT

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In vitro Antioxidant activity, FTIR analysis and Total Phenolic content of Endophytic Fungus Penicillium sp. isolated from Boerhaavia diffusa L.

Shankar

K.P.G

Sathiavelu

2022

RJPT

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Endophytes from medicinal plants are a significant source of various novel biologically active secondary metabolites. Endophytic fungi are a group of fungi that colonize the internal part of the plants without causing any immediate harmful effects. Our study mainly focuses on the isolation and identification of endophytic fungi from the medicinal plant Boerhaavia diffusa Linn belonging to the family Nyctaginaceae. Penicillium sp., a fungal endophyte isolated from Boerhaavia diffusa L. leaves for their bioactive potential. The fungal culture was further grown and extracted by various solvents such as dichloromethane (DCM), butanol and methanol. Different crude extracts were used to study their phytochemical composition, total phenolic content, 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity and fourier transform infrared spectroscopy (FTIR) analysis. The present study reveals that phytochemical screening of different fungal crude extracts indicates the presence of phenol, flavonoids, saponins, tannin, and terpenoids. Dichloromethane crude extract exhibited the highest total phenolic content of 14.4±0.018mg of GAE/g of extract and DPPH scavenging activity of 96% when compared to other solvent extracts. FTIR analysis revealed various functional groups of the compounds present in the extracts. The results indicated that the endophytic fungi Penicillium sp. isolated from medicinal plant Boerhaavia diffusa L. could be a significant source of bioactive compounds.

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Evaluation of Phytochemical Constituents and Antioxidant Activities of Ricinus communis L.

Purushothaman

Chandra

2022

RJPT

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Majority of the modern medicines are derived from bioactive constituents of medicinal plants. The current investigation was designed to evaluate the phytochemical constituents and antioxidant activity of methanolic extract of leaves of Ricinus communis L. Qualitative analysis of phytochemicals viz. tannins, phlobatannins, saponins, flavonoids, steroids, alkaloids, coumarin, terpenoids and cardiac glycosides and quantitative analysis of total phenolics, alkaloids, tannins and flavonoids were performed by using standard protocol. Antioxidant activity was studied through DPPH, ABTS, phosphomolybdenum and reducing power assay. To confirm the phytoconstituents of the leaf extracts, Gas chromatography-Mass spectrometry (GC-MS) method was followed. In the present study, qualitative and quantitative analysis revealed the presence of major class of phytochemicals. Quantitative analysis of alkaloids, flavonoids, tannins and phenols were 32.28 ± 0.28 mg/g, 256.29 ± 0.21 mg QE/g, 175.59 ± 0.78 mg TAE/g, 273.35 ± 2.33 mg GAE/g respectively. The extract showed a good scavenging activity with DPPH (84.22 ± 0.81 %) and the GC-MS chromatogram revealed the presence of 23 peaks with different compounds and Ricinine was found to be the major compound. The presence of these bioactive molecules in R. communis may provide the scientific evidences for the medicinal value and other biological properties.

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Arginase Inhibitory, Antioxidant Activity, Total Phenolic Content and Total Flavonoid Content of Ethyl Acetate Extract of Caesalpiniaturtuosa Roxb Stem Bark

Cited by 6 publications

References 24 publications

Phytochemical, antioxidant, anti-stress and cerebroprotective activity of ethanolic extract of stem of Sarcostemma acidum

Phytochemical, antioxidant, anti-stress and cerebroprotective activity of ethanolic extract of stem of Sarcostemma acidum

In vitro Antioxidant activity, FTIR analysis and Total Phenolic content of Endophytic Fungus Penicillium sp. isolated from Boerhaavia diffusa L.

Evaluation of Phytochemical Constituents and Antioxidant Activities of Ricinus communis L.

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