Arginase Activity and Lecithin/Sphingomyelin (L/S) Ratio in the Amniotic Fluid of Pregnant Women

Bjelaković, Goran; Miladinovic, Petar; Jevtović-Stoimenov, Tatjana; Stojanović, Ivana; Nikolić, Jelena S.; Pavlović, Dušica; Kocić, Gordana; Bjelaković, Marija; Ilic, M; Sokolović, Dušan; Bašić, Jelena

doi:10.1007/s12291-013-0398-9

Cited by 3 publications

(2 citation statements)

References 27 publications

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“…In nonhepatic tissues lacking a complete urea cycle, the ARG1 reaction is considered to be a source of ornithine, which leads to the production of other bioactive molecules, such as polyamines (spermine and spermidine), proline, or glutamic acid (Bjelakovic et al , 2015; Sivashanmugam et al , 2017). Proline is a major component of many structural proteins, especially collagen (Caldwell et al , 2018).…”

Section: Discussionmentioning

confidence: 99%

Arginase 1 and L‐arginine coordinate fetal lung development and the initiation of labor in mice

Yu¹,

Liu²,

Sui³

et al. 2023

EMBO Reports

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Fetal development and parturition are precisely regulated processes that involve continuous crosstalk between the mother and the fetus. Our previous discovery that wild-type mice carrying steroid receptor coactivator (Src)-1 and Src-2 double-deficient fetuses exhibit impaired lung development and delayed labor, which indicates that the signals for parturition emanate from the fetus. In this study, we perform RNA sequencing and targeted metabolomics analyses of the lungs from fetal Src-1/-2 double-knockout mice and find that expression of arginase 1 (Arg1) is significantly decreased, accompanied by increased levels of the Arg1 substrate L-arginine. Knockdown of Arg1 in the lungs of fetal mice induces apoptosis of epithelial cells and dramatically delays initiation of labor. Moreover, treatment of human myometrial smooth muscle cells with L-arginine significantly inhibits spontaneous contractions by attenuating activation of NF-κB and downregulating expression of contraction-associated protein genes. Transcription factors GR and C/EBPβ increase transcription of Arg1 in an Src-1/Src-2-dependent manner. These findings provide new evidence that fetus-derived factors may play dual roles in coordinating fetal lung development and the initiation of labor.

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Section: Discussionmentioning

confidence: 99%

Arginase 1 and L‐arginine coordinate fetal lung development and the initiation of labor in mice

Yu¹,

Liu²,

Sui³

et al. 2023

EMBO Reports

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show abstract

“…We detected abnormal levels of some of these molecules such as phosphatidylcholines or sphingomyelins. It should be underscored that these cell membrane components carry out important functions in gestation and occur in different proportions in different tissues [43,44]. Decreased sphingomyelin levels have been linked to pathological conditions such as maternal malperfusion [45].…”

Section: Discussionmentioning

confidence: 99%

Lipidomic profiling of chorionic villi in the placentas of women with chronic venous disease

et al. 2020

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Background: Chronic venous disease (CVD) is a prevalent lower limb venous pathology that especially affects women, who also show an increased risk of this disease during pregnancy. Studies have shown significant structural changes in the placentas of women with CVD and several markers of tissue damage have been also described. Patients and Methods: To try to understand the different placental pathologies, research efforts have focused on examining metabolomic profiles as indicators of the repercussions of these vascular disorders. This study examines changes produced in the metabolomic profiles of chorionic villi in the placentas of women with CVD. In a study population of 12 pregnant women, 6 with and 6 without CVD, we compared through mass spectroscopy coupled to ultra-high performance liquid chromatography (UHPLC-MS), 240 metabolites in chorionic villus samples. Results: This study is the first to detect in the placental villi of pregnant women with CVD, modifications in lysophosphatidylcholines and amino acids along with diminished levels of other lipids such as triglycerides, sphingomyelins, and non-esterified omega 9 fatty acids, suggesting a role of these abnormalities in the pathogenesis of CVD. Conclusions: Our findings are a starting point for future studies designed to examine the impacts of CVD on maternal and fetal well-being.

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Effects of Pinellia ternata (Thunb.) Berit. on the metabolomic profiles of placenta and amniotic fluid in pregnant rats

Xie

Meng

et al. 2016

Journal of Ethnopharmacology

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Arginase Activity and Lecithin/Sphingomyelin (L/S) Ratio in the Amniotic Fluid of Pregnant Women

Cited by 3 publications

References 27 publications

Arginase 1 and L‐arginine coordinate fetal lung development and the initiation of labor in mice

Arginase 1 and L‐arginine coordinate fetal lung development and the initiation of labor in mice

Lipidomic profiling of chorionic villi in the placentas of women with chronic venous disease

Effects of Pinellia ternata (Thunb.) Berit. on the metabolomic profiles of placenta and amniotic fluid in pregnant rats

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