Argentum–quarz solution in the treatment of anorectal fistulas: Is it possible a conservative approach?

Tomasello, Giovanni; Bellavia, Maurizio; Damiani, F.; Damiano, Giuseppe; Palumbo, Vincenzo Davide; Fiorentini, Tiziana; Puleio, Roberto; Spinelli, Gabriele; Damiani, Provvidenza; Ficarella, Silvia; Bruno, Antonio; Monte, Attilio Ignazio Lo

doi:10.1016/j.mehy.2012.07.015

Cited by 4 publications

(3 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This late phase is also described as the "sustained effects phase" in which silver proteinate experiences a progressive ionization, causing a slow but long-acting effect. It also known that SN has an antiseptic effect, 3 which is based on the protein denaturalization of the bacterial cell wall and membrane. Antimicrobial properties of silver are dependent upon release of biologically active silver ion (Ag + ) from SN.…”

Section: Discussionmentioning

confidence: 99%

“…1 In 2014 Attaallah et al first reported encouraging results supporting conservative treatment of anal fistula using a silver nitrate (SN) 1% solution, with a complete resolution rate up to 52%. 2 SN is known to have an antiseptic action and the capacity to produce a chemical burn destroying the surrounding granulation tissue 3 favouring cicatrization.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Local irrigation with silver nitrate, a non-surgical approach for persistent anal fistula

Placer–Galán

Aguirre–Allende

Enríquez-Navascués

2019

Journal of Coloproctology

View full text Add to dashboard Cite

Purpose Treatment of persistent anal fistula implies a major challenge for surgeons, with risk of additional recurrence and potential continence impairment. We present a non-surgical treatment based on irrigation with silver nitrate 1% solution. Methods This is a prospective study including patients with persistent anal fistula after surgery, who were treated with silver nitrate 1% solution irrigation from May 2015 to March 2017. Patients with evidence of abscess, presence of >1 external opening and those with bowel inflammatory disease were excluded. 3–5 cc of silver nitrate 1% solution were instilled through a catheter. The procedure was repeated on a weekly basis, conducting a maximum of 7 sessions per patient. Results 18 patients (13 male, 72.2%) with a median age of 48 years old (IQR 41–55) were treated using silver nitrate 1% solution. A median of 5 sessions per patient was performed (IQR 3–6). The median follow-up period was 18 months (IQR 9–25). After the described period 8 patients’ (44.4%) presented complete resolution of the fistula, 2 patients’ (11.2%) were classified as partial healing and in 8 patients’ (44.4%) the treatment was considered to fail. 6 patients’ experienced self-limited pain during instillation, with persistence up to 24 h in 2 of them. Conclusions Treatment with silver nitrate 1% solution is a minimally invasive procedure, with a favourable safety profile, that can be performed in an outpatients’ basis achieving a complete healing rate of 44.4%. Therefore, this method should be considered for the treatment of recurrent or persistent anal fistula.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Local irrigation with silver nitrate, a non-surgical approach for persistent anal fistula

Placer–Galán

Aguirre–Allende

Enríquez-Navascués

2019

Journal of Coloproctology

View full text Add to dashboard Cite

show abstract

“…Another noninvasive method in fistula is treatment using silver nitrate (SN) 1% solution. SN is known to have an antiseptic action and the capacity to produce chemical burn destroying the surrounding granulation tissue favoring cicatrisation (14) .…”

Section: Complexmentioning

confidence: 99%

Histoacryle Injection VS. Silver Nitrate Injection in Treatment of Low Non Branching Anal Fistula

El-Baz

Abdel-Wahab

Korany

et al. 2022

Egyptian Journal of Medical Research

View full text Add to dashboard Cite

Background: Anal fistula and anal sepsis are the part of spectrum of anorectal suppurative diseases, A fistula-in-ano is a hollow tract lined with granulation tissue connecting a primary opening inside the anal canal to a secondary opening in the perianal skin through which an abscess has been drained or has spontaneously ruptured. Aim of the Work: To compare injection of histoacryle and irrigation of silver nitrate in treatment of low non branching anal fistula. Patients and Methods: This study was held in Beni-Suief university hospital, at the general surgery department from October 2019 to June 2020 on 50 patients that divided into 2 groups randomly selected (SN group and Histoacryle group). Results: There is a significant difference found between two groups in favor for SN. As silver nitrate is much less expensive with a lower recurrence rates, while histoacryle is more expensive with higher recurrence rates. Conclusion:Both silver nitrate and histoacryle can be used in treatment of low non branching anal fistula effectively with no evident complications and good success rate specially for patients refusing surgery and for patients with high risk for anesthesia, favoring SN injection as it has lower recurrence rates and cheaper cost in comparison with HA injection.

show abstract

Gut microbiota imbalance and chaperoning system malfunction are central to ulcerative colitis pathogenesis and can be counteracted with specifically designed probiotics: a working hypothesis

Bellavia

Tomasello

Romeo

et al. 2013

Med Microbiol Immunol

Self Cite

View full text Add to dashboard Cite

In this work, we propose that for further studies of the physiopathology and treatment for inflammatory bowel diseases, an integral view of the conditions, including the triad of microbiota-heat shock proteins (HSPs)-probiotics, ought to be considered. Microbiota is the complex microbial flora that resides in the gut, affecting not only gut functions but also the health status of the whole body. Alteration in the microbiota's composition has been implicated in a variety of pathological conditions (e.g., ulcerative colitis, UC), involving both gut and extraintestinal tissues and organs. Some of these pathologies are also associated with an altered expression of HSPs (chaperones) and this is the reason why they may be considered chaperonopathies. Probiotics, which are live microorganisms able to restore the correct, healthy equilibrium of microbiota composition, can ameliorate symptoms in patients suffering from UC and modulate expression levels of HSPs. However, currently probiotic therapy follows ex-adiuvantibus criteria, i.e., treatments with beneficial effects but whose mechanism of action is unknown, which should be changed so the probiotics needed in each case are predetermined on the basis of the patient's microbiota. Consequently, efforts are necessary to develop diagnostic tools for elucidating levels and distribution of HSPs and the microbiota composition (microbiota fingerprint) of each subject and, thus, guide specific probiotic therapy, tailored to meet the needs of the patient. Microbiota fingerprinting ought to include molecular biology techniques for 123Med Microbiol Immunol DOI 10.1007/s00430-013-0305-2 sequencing highly conserved DNA, e.g., genes encoding 16S RNA, for species identification and, in addition, quantification of each relevant microbe.

show abstract

Argentum–quarz solution in the treatment of anorectal fistulas: Is it possible a conservative approach?

Cited by 4 publications

References 16 publications

Local irrigation with silver nitrate, a non-surgical approach for persistent anal fistula

Local irrigation with silver nitrate, a non-surgical approach for persistent anal fistula

Histoacryle Injection VS. Silver Nitrate Injection in Treatment of Low Non Branching Anal Fistula

Gut microbiota imbalance and chaperoning system malfunction are central to ulcerative colitis pathogenesis and can be counteracted with specifically designed probiotics: a working hypothesis

Contact Info

Product

Resources

About