Argentaffinoma of the Lung with Carcinoid Syndrome

Joseph, M C; Taylor, Roger R.

doi:10.1136/bmj.2.5198.568

Cited by 27 publications

(2 citation statements)

References 12 publications

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“…Carcinoid tumors are commonly seen in the gastrointestinal tract with frequent metastasis to liver. The first description of carcinoid tumors was in the late 18th century by Lubarsch, followed by Oberndofer in 1907 [13]. In the early 1950s, there were six reported cases of bronchial carcinoid.…”

Section: Discussionmentioning

confidence: 99%

Carcinoid tumor of lung and BRCA mutation: a case report

et al. 2019

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Background A BRCA mutation is a mutation in either of the BRCA1 or BRCA2 genes, which are tumor suppressor genes. Hundreds of different types of mutations in these genes have been identified, some of which have been determined to be harmful, whereas others have no proven impact. BRCA mutations are well known to be associated with breast, uterine, and ovarian cancers along with some nongynecological malignancies involving the peritoneum, prostate, pancreas, skin, stomach, and rectum. However, there are no reported cases to date of an association between carcinoid tumors and a BRCA mutation. Case presentation Our patient was a 33-year-old White woman with BRCA2 mutation who presented to her primary care physician for evaluation of abdominal pain. She underwent computed tomography of her abdomen and pelvis, which showed an incidental finding of infrahilar mass along with renal stones. Further workup with bronchoscopy and biopsy of the mass confirmed it to be a carcinoid tumor of the lung. Conclusions No literature thus far exists describing a connection between BRCA mutations and carcinoid tumors. Early diagnosis and prompt treatment of carcinoid tumors are proven to have impact on survival and prognosis of these patients.

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Section: Discussionmentioning

confidence: 99%

Carcinoid tumor of lung and BRCA mutation: a case report

et al. 2019

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“…Numerous recent reports associate bronchial carcinoid and liver metastases with the carcinoid syndrome. The syndrome has been described with metastases elsewhere than in the liver (Joseph and Taylor, 1960). A search should be made for evidence of the syndrome in all patients with bronchial carcinoid; positive evidence may be assumed to confirm the presence of metastases.…”

Section: Factors Suggesting Long-term Benign Coursementioning

confidence: 99%