Argentaffin Tumor (Carcinoid) Occurring in a Benign Cystic Teratoma of the Testicle

Simon, H; McDonald, John R.; Culp, Ormond S.

doi:10.1016/s0022-5347(17)67688-2

Cited by 48 publications

(18 citation statements)

References 5 publications

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“…Between 1930 and 2006, 61 cases of testicular carcinoid were published, in addition to the present case; the 62 cases comprised 44 in group 1 , six in group 2 [8,17,[41][42][43] and 12 in group 3 [8,16,[44][45][46][47][48][49][50][51][52]. Metastases were described in seven of the 44 cases in group 1 [8,9,15,28,29,32].…”

Section: Resultsmentioning

confidence: 63%

Carcinoid tumours of the testis

Stroosma

Delaere

2008

BJU International

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OBJECTIVETo review previous reports of carcinoid (an endocrine tumour mostly of the gastrointestinal tract) tumours of the testis.METHODSCarcinoid tumours of the testis are rare and can be divided into primary carcinoid (group 1), testicular metastasis from another location (group 2) and carcinoid within a testicular teratoma (group 3). A case of testicular carcinoid within our clinic prompted us to review previous reports; all the cases found were assessed for patient and tumour characteristics, diagnostic tools used, treatment and prognosis.RESULTSIn all, 62 cases were assessed and divided into groups 1 (44 patients), 2 (six) and 3 (12), respectively. Seven patients in group 1 developed metastases. A wide variety of diagnostic tools was used to search for other tumour sites. All patients were treated with orchidectomy. Three patients with a primary carcinoid were treated with adjuvant chemotherapy (two) or radiotherapy (one), with unknown results. All but one of the nine patients who died were known to have metastasis, either from a primary testicular carcinoid or testicular metastases from an intestinal carcinoid.CONCLUSIONWhen a testicular carcinoid tumour is discovered, other tumour sites should be excluded. The most useful diagnostic tools for this purpose seem to be urinary 5‐hydroxyindoleacetic acid measurement, somatostatin receptor scintigraphy, computed tomography and video‐capsule endoscopy. Localized testicular carcinoid tumours have an excellent prognosis after orchidectomy.

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Section: Resultsmentioning

confidence: 63%

Carcinoid tumours of the testis

Stroosma

Delaere

2008

BJU International

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“…There is a strong rationale for the concept that testicular carcinoid tumor is of germ cell origin. Testicular carcinoids are typically encountered in a background of teratoma, a germ cell neoplasm that shares the same clonal origin with coexisting germ cell tumors, including embryonal carcinoma, yolk sac tumor, and choriocarcinoma (1,(17)(18)(19)(20)(21)(22)(23). Additionally, carcinoid tumor has been found as an element of teratomatous tumors in the mediastinum (22,23), kidney (19, 24 -27), retroperitoneum (28), and in sacrococcygeal teratomas in children (29,30).…”

Section: Discussionmentioning

confidence: 99%

Germ Cell Origin of Testicular Carcinoid Tumors

Abbosh¹,

Zhang²,

MacLennan

et al. 2008

Clinical Cancer Research

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Purpose: Carcinoids are neuroendocrine tumors and most frequently occur within tissues derived from the embryonic gut.These tumors can occur in any organ site but are rare in the testis. The cell type giving rise to testicular carcinoid is unknown.We hypothesized that testicular carcinoid may have a germ cell origin. Experimental Design: We describe our analysis of protein and genetic markers of germ cell neoplasia, using immunohistochemistry and fluorescence in situ hybridization, in four testicular carcinoid tumors. Results: All four cases of testicular carcinoid tumor arose in a background of mature teratoma. Isochromosome 12p was identified in carcinoid tumor cells in all four samples. 12p overrepresentation was also observed in three cases. Isochromosome 12p and 12p overrepresentation were present in cells of coexisting mature teratoma in three cases. Carcinoid tumors showed strong immunoreactivity for synaptophysin and chromogranin, but no immunoreactivity for OCT4, CD30, c-kit,TTF-1, and CDX2. Membranous and cytoplasmic staining for h-catenin was detected in three cases. Conclusion: Our findings suggest that testicular carcinoid represents a phenotypic expression of testicular teratoma and is of germ cell origin.

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“…Simon et al (2) reported the first primary testicular carcinoid tumor (TCT) in 1954, more than 60 cases of TCT have been reported, although it remains an uncommon disease (3).…”

Section: Introductionmentioning

confidence: 99%

Primary carcinoid tumor of the testis: A rare case

Büberal¹,

Sarsık

Şimşir

et al. 2018

Ege Tıp Dergisi

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Neuroendocrine tumors most commonly occur in the gastrointestinal tract, lungs and pancreas. Primary testicular neuroendocrine tumors are rare, constituting 0.23% of all testicular tumors. A 35-year-old man presented to urology department with a painless left scrotal mass. He had no history of trauma. Scrotal Doppler ultrasonography revealed a 2×1.5 cm, well-circumscribed, solid lesion. Tumor marker levels were normal and staging computed tomography demonstrated no evidence of metastasis. The patient subsequently underwent left radical orchiectomy. The orchiectomy material, grossly showed a 1.4x1.2 cm, well-circumscribed, yellow, solid mass. On histopathologic examination, primary testicular carcinoid tumors cannot be distinguished from welldifferentiated neuroendocrine carcinoma. The diagnosis of a primary testicular carcinoid tumor was made after ruling out an extratesticular neuroendocrine tumor using clinical and radiological data. This rare case is presented with clinical, morphological and immunohistochemical features.

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Argentaffin Tumor (Carcinoid) Occurring in a Benign Cystic Teratoma of the Testicle

Cited by 48 publications

References 5 publications

Carcinoid tumours of the testis

Carcinoid tumours of the testis

Germ Cell Origin of Testicular Carcinoid Tumors

Primary carcinoid tumor of the testis: A rare case

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