Arg753Gln Polymorphisms in the Toll-Like Receptor 2 Gene are Associated with Cytomegalovirus Infection in Egyptian Bone Marrow Recipients

El-Nabi, Sobhy Hassab; Sayed, Samia Youssef; Abdelhafez, Mohamed A.; Elfiky, Mohamed; Moneim, Ahmed E. Abdel; El-Garawani, Islam

doi:10.2174/1871530319666191018124710

Cited by 8 publications

(11 citation statements)

References 26 publications

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“…Similarly, El-Nabi et al 31 reported that the Arg753Gln variant in the TLR2 gene was linked to CMV infection in Egyptian bone marrow recipients. They showed that 85% of the patients screened were G/G homozygous, whereas 15% were G/A heterozygous; there were no patients that were homozygous for (A/A).…”

Section: Discussionmentioning

confidence: 92%

Impact of Toll-Like Receptor 2 and 9 Gene Polymorphisms on COVID-19: Susceptibility, Severity, and Thrombosis

Alhabibi¹,

Hassan²,

Elbaky³

et al. 2023

JIR

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Background Toll-like receptors (TLRs) play an important role in activation of innate and adaptive immune responses. Aim We aimed to detect the association between TLR2 rs5743708 G>A and TLR9 rs5743836 C>T variants and COVID-19 disease susceptibility, severity, and thrombosis by using neutrophil extracellular traps (NETs). Subjects and Methods We included 100 adult COVID-19 patients as well as 100 age- and gender-matched normal controls. Participants were genotyped for TLR2 rs5743708 and TLR9 rs5743836. Citrullinated Histone (H3) was detected as an indicator of NETs. Results The mutant (G/A and C/C) genotypes and (A and C) alleles of TLR2 rs5743708 and TLR9 rs5743836, respectively, have been significantly related to a higher risk of COVID-19 infection, representing a significant risk factor for the severity of COVID-19. There was no significant association between the two variants and citrullinated histone (H3). Conclusion TLR2 rs5743708 and TLR9 rs5743836 variants have been significantly related to a higher risk and severity of COVID-19 infection but had no effect on thrombus formation.

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Section: Discussionmentioning

confidence: 92%

Impact of Toll-Like Receptor 2 and 9 Gene Polymorphisms on COVID-19: Susceptibility, Severity, and Thrombosis

Alhabibi¹,

Hassan²,

Elbaky³

et al. 2023

JIR

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“…1 In the last few decades, important measures have been adopted to control and prevent viral infections across the globe. 2,3 These measures include the introduction of a safe and effective vaccine against HBV infection for all newborns and high-risk groups in all WHO member countries, screening of blood and blood derivatives 4 and the implementation of more efficient tests such as nucleic acid testing (NAT). 5 In addition, treatments for chronic HBV infection have been updated and their efficiency improved.…”

Section: Introductionmentioning

confidence: 99%

Anti‐HBcand hepatitis B virusDNAamongHBsAg‐negative blood donors from the main central blood bank units in Eastern Libya

El-Nabi

El-Garawani

Ismail

et al. 2020

Transfusion Medicine

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Background: Post-transfusion hepatitis B virus (PTHB) infection is still a public health problem in the world. In many developed countries, nucleic acid testing (NAT) for detection of Hepatitis B Virus (HBV)-DNA has been implemented to enhance blood donation safety. In Libya, however, the testing for HBV infection is limited to the detection of HBV surface antigen (HBsAg) only. Objectives: To determine the frequency of anti-Hepatitis B core antibody (HBc) and HBV-DNA in HBsAg-negative, anti-HBc-positive blood donors in the main Central Blood Bank Units (CBBUs) in eastern Libya. Methods: One thousand blood samples were obtained from healthy blood donors at the five main CBBUs in eastern Libya. The samples were screened for HBsAg and anti-HBc. Real-time polymerase chain reaction (PCR) was carried out to detect HBV-DNA in all anti-HBc-positive samples. Results: A total of 94 (9.4%) donors were positive for anti-HBc. Of the 94 anti-HBcpositive samples, 9 samples (9.5%) tested positive for HBV-DNA by real-time PCR. Conclusion: The rate of anti-HBc among blood donors in this study (9.4%) was similar to that reported from other regions in the country. In the absence of advanced tests for the detection of HBV infection in blood donors, such as NAT, anti-HBc should be routinely tested for, at least for first-time donors.

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“…The valvuloseptal heart defect may occur due to disruptions in the signal transformation of endocardial cushions [12]. TGFBR2 is expressed during heart development in embryonic myocytes, endothelial cells, and endocardial cushion of mice [13].…”

Section: Introductionmentioning

confidence: 99%

Association of TGFBR2 gene polymorphisms (rs6785358 and rs764522) with congenital heart disease susceptibility in Egyptians

Dawood,

Shabana,

El-Midany

et al. 2024

Exploration of Medicine

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Aim: Transforming growth factor beta (TGF-β) receptor II (TGFBR2) is a basic constituent of TGF-β signalling pathway and is important in heart development. This study investigates the relationship between TGFBR2 gene variance and congenital heart defects (CHD) among Egyptians. Methods: The study involved 75 CHD-affected subjects and 100 healthy controls. Genotyping of two selected tag single nucleotide polymorphisms (tagSNPs, rs6785358, rs764522) within the TGFBR2 gene was conducted using polymerase chain reaction-restriction fragment length polymorphism method (PCR-RFLP) assays. Results: Significant genotype differences were found for rs764522 and rs6785358 (P < 0.05). In the case of rs6785358, the G/G genotype was more prevalent in cases than controls (18.7% vs. 4.0%). This significance was observed in both the codominant model [A/A vs. A/G vs. G/G; odds ratio (OR) = 0.20, 95% confidence interval (CI) = 0.06–0.66, P = 0.0073] and the recessive model (A/A + A/G vs. G/G; OR = 0.19, 95% CI = 0.06–0.60, P = 0.0018). For rs764522, the G/G genotype was more prevalent in cases than controls (21.3% vs. 0.0%). Significant associations were observed in the codominant model (C/C vs. C/G vs. G/G; OR = 0.43, 95% CI = 0.02–0.90, P < 0.0001), as well as in the dominant model (C/C vs. C/G + G/G) and recessive model (C/C + C/G vs. G/G; P < 0.0001). Gender-specific analysis indicated that the C/G genotype was less common in male cases compared to females and controls (OR = 0.24, 95% CI = 0.07–0.84). For rs6785358, the G/G genotype frequency was higher in male cases compared to females and controls (OR = 0.10, 95% CI = 0.01–0.88 and OR = 0.22, 95% CI = 0.05–0.94, respectively). Conclusions: These findings indicate that TGFBR2 gene SNPs (rs6785358 and rs764522) may be risk factors for CHD in Egyptians.

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Arg753Gln Polymorphisms in the Toll-Like Receptor 2 Gene are Associated with Cytomegalovirus Infection in Egyptian Bone Marrow Recipients

Cited by 8 publications

References 26 publications

Impact of Toll-Like Receptor 2 and 9 Gene Polymorphisms on COVID-19: Susceptibility, Severity, and Thrombosis

Impact of Toll-Like Receptor 2 and 9 Gene Polymorphisms on COVID-19: Susceptibility, Severity, and Thrombosis

Anti‐HBcand hepatitis B virusDNAamongHBsAg‐negative blood donors from the main central blood bank units in Eastern Libya

Association of TGFBR2 gene polymorphisms (rs6785358 and rs764522) with congenital heart disease susceptibility in Egyptians

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