Arg399Gln XRCC1 Polymorphism and Risk of Squamous Cell Carcinoma of the Head and Neck in Jordanian Patients

Sobiahe, Ammar; Hijazi, Eman; Al‐Ameer, Hamzeh J.; Almasri, Yazan; Jarrar, Yazun; Zihlif, Malek; Shomaf, Maha; Al‐Rawashdeh, Baeth

doi:10.31557/apjcp.2020.21.3.663

Cited by 7 publications

(13 citation statements)

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“…XRCC1 is essential in the assembly of the BER pathway because it interacts and coordinates other major components such as polyADP-ribose polymerase-1 enzyme, DNA polymerase H, and DNA ligase III, which are all involved in the repair of single-stranded DNA breaks induced by ROS (Fig. 1B) [11][12][20][21][22]. The XRCC1 gene is located on chromosome 19q13.2 with a length of 33 kb, and comprises 17 exons and 16 introns [12,14,19].…”

Section: State Of Knowledgementioning

confidence: 99%

“…Some polymorphisms in the XRCC1 gene have been used as biomarkers of susceptibility to DNA damage by pesticides. In this regard, the clinically relevant polymorphisms are rs1799782 (exon 6 Arg194Trp C/T) and rs25487 (exon 10 Arg399Gln G/A) [12][13][19][20][21]. The Arg194Trp polymorphism is located between two protein domains: the NH2-terminal domain and the BRCT1 domain that directly affects enzymatic function [14,19].…”

Section: State Of Knowledgementioning

confidence: 99%

“…The Arg399Gln polymorphism is located at the C-terminus of the BRCT1 domain. It regulates the biological interaction with polyADP-ribose polymerase (PARP), resulting in reduced repair capacity, increased mutagenic sensitivity, and higher levels of DNA damage [12,[19][20][21].…”

Section: State Of Knowledgementioning

confidence: 99%

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Genetic profile for the detection of susceptibility to poisoning by exposure to pesticides

Galvez¹,

Salazar-Flores²,

Sanchez³

et al. 2021

Ann Agric Environ Med.

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Section: State Of Knowledgementioning

confidence: 99%

Section: State Of Knowledgementioning

confidence: 99%

See 1 more Smart Citation

Genetic profile for the detection of susceptibility to poisoning by exposure to pesticides

Galvez¹,

Salazar-Flores²,

Sanchez³

et al. 2021

Ann Agric Environ Med.

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show abstract

“…DNA repair systems are key to maintain genomic integrity and play crucial roles in preventing mutations. X-ray Repair cross complementing Group 1 (XRCC1) is a common DNA repair gene that mainly engages in DNA base excision repair (BER), nucleotide excision repair (NER) and chain fracture repair, 5 Studies have shown that single nucleotide polymorphisms (SNP) in the coding region or population can affect DNA repair ability and is closely related to genetic susceptibility of many tumors including HNC. 5 The most common SNPs leading to amino acid substitution are at exons 6 (Arg194Trp) and 9 (Arg280His) and 10 (Arg399Gln).…”

Section: Introductionmentioning

confidence: 99%

“…X-ray Repair cross complementing Group 1 (XRCC1) is a common DNA repair gene that mainly engages in DNA base excision repair (BER), nucleotide excision repair (NER) and chain fracture repair, 5 Studies have shown that single nucleotide polymorphisms (SNP) in the coding region or population can affect DNA repair ability and is closely related to genetic susceptibility of many tumors including HNC. 5 The most common SNPs leading to amino acid substitution are at exons 6 (Arg194Trp) and 9 (Arg280His) and 10 (Arg399Gln). Interestingly, these amino acid changes may affect protein-protein interactions between XRCC1 and other BER proteins, which in turn may alter DNA repair capabilities.…”

Section: Introductionmentioning

confidence: 99%

The Association Between the XRCC1 Arg399Gln Polymorphism and the Risk of Head and Neck Cancer: An Updated Meta-Analysis Including 14586 Subjects

Xia

Wang

2021

Technol Cancer Res Treat

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Background: Accumulated evidence shows that DNA repair gene X-ray repair cross complementing group 1 (XRCC1) may determine individual susceptibility to head and neck cancer (HNC) as a major DNA repair gene. However, the results from previous studies have been conflictive and inconsistent. In order to more accurately estimate and integrate the association between XRCC1 Arg399Gln polymorphism and HNC risk, we conducted a meta-analysis including 14586 subjects. Methods: In this meta-analysis, literatures were collected up until September 15, 2020 through multifarious retrieval strategies by searching through electronic databases of PubMed, Cochrane Library, EMBASE, Medline, Web of Science and CNKI. The association between the XRCC1 Arg399Gln polymorphism and HNC was analyzed through calculating summary odds ratios (OR) and 95% confidence intervals (CI). Results: Thirty-one studies consisting of 6025 cases and 8561 controls were identified and analyzed. No significant association between XRCC1 Arg399Gln polymorphisms and HNC risk was found under the allelic (OR = 0.94, 95% CI: 0.82-1.07, P = 0.35), homozygous (OR = 0.99, 95% CI: 0.81-1.21, P = 0.91), heterozygous (OR = 1.01, 95% CI: 0.90-1.13, P = 0.91), dominant (OR = 1.05, 95% CI: 0.85-1.29, P = 0.67) or recessive (OR = 0.93, 95% CI: 0.80-1.08, P = 0.35) genetic models in the overall comparison. In addition, subgroup analyses according to tumor site also displayed no significant association between XRCC1 Arg399Gln polymorphisms and HNC risk. However, subgroup analyses based on ethnicity indicated that HNC risk was significantly related to Arg399Gln genetic heterozygous model (OR = 1.21, 95%CI: 1.04-1.42, P = 0.02) and dominant model (OR = 1.27, 95%CI: 1.02-1.60, P = 0.04) in Caucasians populations. Conclusion: The results from this meta-analysis suggest that the XRCC1 Arg399Gln variants (Arg/Gln and Arg/Arg+Arg/Gln) may contribute to high HNC risk among Caucasians. Further well-designed studies and larger sample sizes are needed to validate our findings.

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The Incidence of the XRCC1 rs25487 and PON1 rs662 Polymorphisms in a Population from Central Brazil: Patterns in an Area with a High Level of Agricultural Activity

et al. 2023

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In Brazil, high levels of agricultural activity are re ected in the consumption of enormous amounts of pesticide. The production of grain in Brazil has been estimated to reach 289.8 million tons in the 2022 harvest, an increase of 14.7% in comparison with 2021, with an even greater increase being predicted for Goiás, one of the country's principal grain producing states. These advances are likely associated with a progressive increase in the occupational exposure of rural workers to pesticides. The PON1 gene activates the enzymes involved in phase I of liver detoxi cation. The rs662 variant of this gene is known to modify the activity of the PON1 enzyme, which can increase the susceptibility of an individual to pesticides, leading to more severe symptoms or the development of diseases. The present study describes the frequencies of the rs25487 (of the XRCC gene) and rs662 variants and their haplotypes in a sample population from Goiás, Brazil, and compares the frequencies with other populations from around the world to verify the variation in the distribution of these Single Nucleotide Polymorphisms (SNPs). The study analyzed samples taken from 494 unrelated individuals resident in the state of Goiás. The A allele of the rs25487 variant had a frequency of 26% in the Goiás study population, and the modi ed rs662 G allele had a frequency of 42.8%. Four haplotypes were recorded for the rs25487 (G > A) and rs662 (A > G) markers, with a frequency of 11.9% being recorded for the A/G haplotype (both modi ed alleles), 30.8% for the G/G haplotype, 14.3% for the A/A haplotype, and 42.8% for the G/A haplotype (both wild-type alleles). In conclusion, we demonstrated the distribution of important SNPs associated with pesticide exposure in an area that presents a high level of agricultural activity.

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Arg399Gln XRCC1 Polymorphism and Risk of Squamous Cell Carcinoma of the Head and Neck in Jordanian Patients

Abstract: 1999). X-ray repair cross-complementing group 1 (XRCC1) is a key protein in BER and closely associated with BER pathway coordination due to interacting with most components of the BER short-patch pathway (Caldecott et al., 1996; Marintchev et al., 2000). There are many single

Cited by 7 publications

References 10 publications

Genetic profile for the detection of susceptibility to poisoning by exposure to pesticides

Genetic profile for the detection of susceptibility to poisoning by exposure to pesticides

The Association Between the XRCC1 Arg399Gln Polymorphism and the Risk of Head and Neck Cancer: An Updated Meta-Analysis Including 14586 Subjects

The Incidence of the XRCC1 rs25487 and PON1 rs662 Polymorphisms in a Population from Central Brazil: Patterns in an Area with a High Level of Agricultural Activity

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