Arg16Gly β2-Adrenergic Receptor Gene Polymorphism in Japanese Patients with Aspirin-Exacerbated Respiratory Disease

Kohyama, Kenya; Abe, Shyuzo; Kodaira, Kazumi; Yukawa, Tatsuo; Hozawa, Soichiro; Morioka, Junichiro; Inamura, Hiroaki; Ota, Masaho; Sagara, Hironori; Schwartz, Lawrence B.; Kurosawa, Motohiro

doi:10.1159/000324463

Cited by 17 publications

(12 citation statements)

References 74 publications

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“…In addition, one article [28] was excluded as it was in Polish. Ultimately, 46 articles [8]–[11], [13], [29]–[69] met the inclusion criteria (Figure 1). The characteristics of each article are shown in Table 1.…”

Section: Resultsmentioning

confidence: 99%

Beta-2 Adrenergic Receptor (ADRB2) Gene Polymorphisms and the Risk of Asthma: A Meta-Analysis of Case-Control Studies

et al. 2014

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Background and ObjectiveA number of studies have assessed the relationship between beta-2 adrenergic receptor (ADRB2) gene polymorphisms and asthma risk. However, the results are inconsistent. A meta-analysis that focused on the association between asthma and all ADRB2 polymorphisms with at least three case-control studies was thus performed.MethodsA literature search of the PubMed, Embase, Web of Science, CNKI, and Wangfang databases was conducted. Odds ratios with 95% confidence intervals were used to assess the strength of associations.ResultsArg16Gly, Gln27Glu, Thr164Ile, and Arg19Cys single nucleotide polymorphisms (SNPs) were identified in 46 case-control studies. The results showed that not all of the SNPs were associated with asthma in the overall population. Significant associations were found for the Arg16Gly polymorphism in the South American population via dominant model comparison (OR = 1.754, 95% CI = 1.179–2.609, I2 = 16.9%, studies = 2, case = 314, control = 237) in an analysis stratified by ethnicity. For the Gln27Glu polymorphism, a protective association was found in children via recessive model comparison (OR = 0.566, 95% CI = 0.417–0.769, I2 = 0.0%, studies = 11, case = 1693, control = 502) and homozygote genotype comparison (OR = 0.610, 95% CI = 0.434–0.856, I2 = 0.0%, studies = 11, case = 1693, control = 1502), and in adults via dominant model comparison (OR = 0.864, 95% CI = 0.768–0.971, I2 = 46.9%, n = 18, case = 3160, control = 3433).ConclusionsNone of the ADRB2 gene polymorphisms were reproducibly associated with a risk of asthma across ethnic groups in the general population.

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Section: Resultsmentioning

confidence: 99%

Beta-2 Adrenergic Receptor (ADRB2) Gene Polymorphisms and the Risk of Asthma: A Meta-Analysis of Case-Control Studies

et al. 2014

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“…52, 54, 151 A candidate gene approach has identified an association between CRS and variation in the gene for the adrenergic beta-2 receptor ( ADRB2 ), 152 which has been linked to AERD, asthma exacerbations, and bronchodilator response among patients with asthma. 153-155 A recent study of Chinese patients (306 CRSwNP, 332 CRSsNP, 315 controls) has identified an association between CRSwNP, CRSsNP, and Ring1 and YY1 binding protein ( RYBP ) (CRSwNP: OR, 2.76, P = 3.24 × 10 −6 ; CRSsNP: OR, 2.45, P = 4.12 × 10 −5 ); these findings remained significant after correction for multiple statistical testing. 91 RYBP is a pleomorphic molecule that binds transcription factors and apoptotic mediators 91 ; its direct effect on CRS pathogenesis remains unclear.…”

Section: Genetics Of Crs: Current State Of the Field And Limitations mentioning

confidence: 99%

Genetics of chronic rhinosinusitis: State of the field and directions forward

Hsu

Avila

Kern

et al. 2013

Journal of Allergy and Clinical Immunology

107

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The etiology of chronic rhinosinusitis (CRS) remains unclear. Study of the genetic susceptibility to CRS may be a valuable strategy to understand the pathogenesis of this burdensome disorder. The purpose of this review is to critically evaluate the current literature regarding the genetics of CRS in a comprehensive fashion. The most promising findings from candidate gene studies include the Cystic Fibrosis Transmembrane Conductance Regulator gene (CFTR), as well as genes involved in antigen presentation, innate and adaptive immune responses, tissue remodeling, and arachidonic acid metabolism. We also review the few hypothesis-independent genetic studies of CRS (i.e., linkage analysis and pooling-based genome-wide association studies). Interpretation of the current literature is limited by challenges with study design, sparse replication, few functional correlates of associated polymorphisms, and inadequate examination of linkage disequilibrium or expression quantitative trait loci for reported associations. Given the relationship of CRS to other airway disorders with well-characterized genetic components (e.g., asthma), study of the genetics of CRS deserves increased attention and investment, including the organization of large, detailed, and collaborative studies to advance knowledge of the mechanisms that underlie this disorder.

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“…The possible role of arachidonic acid metabolites, such as LTs, in the pathogenesis of AERD has also been suggested (1). We recently reported that the Arg16Gly β 2 -adrenergic receptor gene polymorphism in AERD is different from that in ATA (24). In the present study, we extended our investigations to explore the genetic determinations of AERD.…”

Section: Discussionmentioning

confidence: 58%

“…The target DNA sequence of CRTH2 -466T>C was amplified using a set of primers (forward 5'-GAGCTGCATGGAGGATCTGT-3'; reverse 5'-AGGACTCCTTTTTCCCATCC-3'). Allelic discrimination assay for SNPs relating to the expression of TBXA2R +795T>C and CRTH2 -466T>C (rs11085026 and rs634681, respectively) was carried out using the previously described SNP detection system, sequence-specific thermalelution chromatography (23,24). All subjects and researchers remained unaware of the genotype until the final analysis.…”

Section: Methodsmentioning

confidence: 99%

Thromboxane A2 receptor +795T>C and chemoattractant receptor-homologous molecule expressed on Th2 cells -466T>C gene polymorphisms in patients with aspirin-exacerbated respiratory disease

Kohyama¹,

Hashimoto²,

Abe³

et al. 2011

Mol Med Report

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Abstract.It is well known that aspirin-exacerbated respiratory disease (AERD) is more common in women than in men, however, whether gene polymorphisms of the thromboxane A 2 receptor (TBXA2R) and chemoattractant receptorhomologous molecules expressed on Th2 cells (CRTH2) are associated with the susceptibility of AERD remains unknown. In this study, we examined the gene polymorphisms in a Japanese population. DNA specimens were obtained from the following three groups: 96 patients with AERD, 500 patients with aspirin-tolerant asthma (ATA) and 100 normal controls. The target DNA sequence of each gene was amplified, and an allelic discrimination assay for single nucleotide polymorphisms relating to expression of each gene was carried out. The frequencies of the CC/CT genotype of TBXA2R +795T>C were higher than those of the TT genotype in AERD patients compared to ATA patients (P=0.015). In female AERD patients, but not in males, frequencies of the CC/CT genotype were higher than those of the TT genotype of TBXA2R +795T>C compared to female ATA patients (P=0.013). Also, frequencies of the TT genotype of CRTH2 -466T>C were higher than those of the CC/CT genotype in AERD patients compared to ATA patients (P=0.034). In female AERD patients, but not in male, frequencies of the TT genotype were higher than those of the CC/CT genotype of CRTH2 -466T>C in AERD patients compared to female ATA patients (P=0.046). Based on our investigations, no significant relationship was found between the genotype and the clinical characteristics according to these gene polymorphisms in AERD patients. Our results suggest that an association between the TBXA2R and CRTH2 gene polymorphisms with AERD may exist in the Japanese population.

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Arg16Gly β2-Adrenergic Receptor Gene Polymorphism in Japanese Patients with Aspirin-Exacerbated Respiratory Disease

Cited by 17 publications

References 74 publications

Beta-2 Adrenergic Receptor (ADRB2) Gene Polymorphisms and the Risk of Asthma: A Meta-Analysis of Case-Control Studies

Beta-2 Adrenergic Receptor (ADRB2) Gene Polymorphisms and the Risk of Asthma: A Meta-Analysis of Case-Control Studies

Genetics of chronic rhinosinusitis: State of the field and directions forward

Thromboxane A2 receptor +795T>C and chemoattractant receptor-homologous molecule expressed on Th2 cells -466T>C gene polymorphisms in patients with aspirin-exacerbated respiratory disease

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