Arg Allele of P53 Gene Codon72 is a Risk Factor for Breast Cancer in Senegalese Women

Yacouba, D; Djp, Demba; Rokhaya, Ndiaye-Diallo; Ahmadou, Dieye Aliouneand Dem; D, Doudou; DM, Moustapha; BS, Abdoul; GT, Fatou; NE, Malick; GP, Madieye; Ka, Sidy; Fatimata, Mbaye; Fatou, T; Alassane, T; Babacar, M; Gora, Diop; Mbacke, Sembene Pape; LS, Philomène; Aynina, C; DP, Amadou; Oumar, F; Alioune, D

doi:10.4172/1747-0862.1000300

Cited by 2 publications

(1 citation statement)

References 24 publications

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“…The results confirmed the high frequency of the guanine (C to G) at position 357 compared to a control European non-cancer population selected from the GnomAD v2.1, indicating a very significant association (p<0.0001) of this SNP and prostate cancer risk, with odds ratio of 7.937 (IC 95% 5.37-11.00). Several reports have described a similar significant association of the R72 SNP with the risk of developing cutaneous melanoma, breast cancer, or prostate cancer [17][18][19][20] . The study on PCa compared 187 Iranian patients with 185 control individual negative for cancer 20 .…”

Section: Discussionmentioning

confidence: 65%

Association of the rs1042522 SNP with prostate cancer risk: a study of cancer tissues, primary tumor cultures and serum samples from a European Caucasian population

Toscano-Guerra,

Maggio,

García

et al. 2024

Preprint

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Prostate cancer (PCa) is the most common cancer in men and the third leading cause of cancer death in Europe. TheTP53gene, the most frequently mutated gene in human cancer, is a tumor suppressor gene with crucial functions in preventing tumor development. The single nucleotide polymorphism rs1042522, characterized by the substitution of a proline (PRO) for an arginine (ARG) at the position 72 of the p53 protein (P72R SNP), was studied in 12 primary tumor cultures from prostate biopsies of untreated hormone-naïve patients (hnPCs) with aggressive-metastatic cancer (Gleason ≥8), 11 radical prostatectomies, and a cohort of 94 serums from patient with aggressive prostate cancer using DNA sequencing and melting curve analysis. The results identified a high frequency of the P72R SNP in prostate cancer samples compared to the general European (non-cancer) population, suggesting a very significant association (p<0.0001) between this SNP and the risk of prostate cancer with an odds ratio of 7.937 (IC 95% 5.37-11.00). The G allele (R72) was more frequent in patients with high Gleason scores (≥8) suggesting its association to more undifferentiated-malignant PCa lesions.

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Section: Discussionmentioning

confidence: 65%

Association of the rs1042522 SNP with prostate cancer risk: a study of cancer tissues, primary tumor cultures and serum samples from a European Caucasian population

Toscano-Guerra,

Maggio,

García

et al. 2024

Preprint

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show abstract

Association of the rs1042522 SNP with prostate cancer risk: a study of cancer tissues, primary tumor cultures, and serum samples from a Spanish Caucasian population

Toscano-Guerra,

Maggio,

García

et al. 2024

Front. Oncol.

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BackgroundProstate cancer (PCa) is a leading cause of cancer-related deaths in European men, emphasizing the urgent need for effective risk assessment strategies. The TP53 gene, a tumor suppressor gene frequently mutated in cancer, commonly harbors the rs1042522 single nucleotide polymorphism (SNP), known as the P72R SNP, which may influence PCa susceptibility. This study investigated the prevalence of the P72R SNP in European Caucasian PCa samples and its association with PCa risk.MethodsGenotyping was conducted on 12 hormone-naïve aggressive PCa cultures (hnPCs) from untreated patients (Gleason ≥8), 11 radical prostatectomies (RP), and 94 serum samples using DNA Sanger sequencing and melting curve analysis. Comparative analysis utilized data from the GnomAD database’s European Caucasian non-cancer population.ResultsOur results demonstrate a significantly higher frequency of the P72R SNP in PCa samples and serums compared to the general European non-cancer population. A robust and statistically significant association (p < 0.0001) between the SNP and prostate cancer risk was identified, with an odds ratio of 7.937 (95% CI 5.37-11.00). Notably, the G allele (R72) showed a pronounced prevalence in high Gleason score (≥8) patients, although statistical significance was not reached. These results highlight a potential association with undifferentiated and malignant PCa lesions.ConclusionThe compelling association between the P72R SNP and prostate cancer risk underscores the potential utility of this marker for the early identification of patients at risk of aggressive metastatic prostate cancer. This insight could empower further research to intervene at an early stage by offering enhanced opportunities for timely and targeted interventions.

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Arg Allele of P53 Gene Codon72 is a Risk Factor for Breast Cancer in Senegalese Women

Cited by 2 publications

References 24 publications

Association of the rs1042522 SNP with prostate cancer risk: a study of cancer tissues, primary tumor cultures and serum samples from a European Caucasian population

Association of the rs1042522 SNP with prostate cancer risk: a study of cancer tissues, primary tumor cultures and serum samples from a European Caucasian population

Association of the rs1042522 SNP with prostate cancer risk: a study of cancer tissues, primary tumor cultures, and serum samples from a Spanish Caucasian population

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