Arenesulfonylheterocycles (I): Synthesis and reactions of 2‐benzenesulfonyl‐4,5‐dichloropyridazin‐3‐ones with amines

Kweon, Deok Heon; Kim, Ho Kyun; Kim, Jeum Jong; Chung, Hyun A.; Lee, Woo Song; Kim, Sung Kyu; Yoon, Yong Jin

doi:10.1002/jhet.5570390129

Cited by 22 publications

(3 citation statements)

References 8 publications

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“…4,5-Dichloro-2-( p -nitrobenzenesulfonyl)pyridazin-3(2 H )-one ( 5 ) could be prepared by the reaction of 4,5-dichloropyridazin-3(2 H )-one with p -nitrobenzenesulfonyl chloride in moderate to excellent yields (method C in Scheme ). 2-Nitro-4,5-disubstituted pyridazin-3(2 H )-ones 6 were successfully synthesized through the reaction of the corresponding pyridazin-3(2 H )-ones with Cu(NO 3 ) 2 ·3H 2 O and acetic anhydride at room temperature in good to excellent yields (method D in Scheme ). Kim et al reported for the first time the preparation of 2-cyano-4,5-disubstituted pyridazin-3(2 H )-ones 7 and utilized them for chemoselective electrophilic cyanation.…”

Section: Preparation Of 2-substituted 45-dichloropyridazin-3(2h)-onesmentioning

confidence: 99%

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Recent Progress in the Chemistry of Pyridazinones for Functional Group Transformations

et al. 2017

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While N-hetereocycles have received significant attention in organic synthesis and other research fields, the chemistry of pyridazine, a six-membered aromatic ring with two adjacent nitrogen atoms, and its derivatives has been relatively little understood. This Synopsis describes recent progress made in the synthesis of pyridazine derivatives-particularly, pyridazin-3(2H)-ones-and their utility as efficient and recyclable functional group carriers for various important organic reactions.

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Section: Preparation Of 2-substituted 45-dichloropyridazin-3(2h)-onesmentioning

confidence: 99%

“…N -Benzenesulfonylation of 1° and 2° amines with 2-benzenesulfonyl-4,5-dichloropyridazin-3(2 H )-ones 5 has been reported . Compounds 5 have the sulfonyl-transfer potential over the nucleophiles such as 1° and 2° amines, carboxylates, and alkoxides.…”

Section: Pyridazin-3(2h)-ones As Recyclable Functional Group Carriersmentioning

confidence: 99%

Recent Progress in the Chemistry of Pyridazinones for Functional Group Transformations

et al. 2017

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“…The sub-models have a similar logical structure to the land use design process of Urban Land Use Planning [28,31]. In other words, the program structure is designed to first identify the location and area of developable land by usage, then to project the demand in a non-spatial manner by usage, and finally to allocate the demand to the lands deemed suitable for development [27,32].…”

Section: Introductionmentioning

confidence: 99%

Planning Support Systems (PSS)-Based Spatial Plan Alternatives and Environmental Assessment

Choi

Lee²

2016

Sustainability

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Spatial planning is at the core of national land and urban development. Many countries and cities seek sustainable development through various means such as coordinated environmental planning, environmental assessment, and internalization of environmental analysis and planning. A Planning Support System (PSS) is a GIS (Geographic Information System)-based, spatial decision-making support system that incorporates a variety of theories and pertinent models. This study adopted the "What if?" model to design an alternative spatial plan that includes generation of predictive scenarios and is relatively easy to use. In the cities studied, we identified a total of six scenarios based on the main drivers of development-namely, population and spatial policies. Subsequently, we assessed the alternatives for their environmental impact, preparing sensitivity maps for each major environmental issue in the target area (natural ecosystem, air and microclimate, natural disasters). One projected advantage of the "What if?" model is that its digital visualization of proposed plans may improve public awareness and involvement. Furthermore, the tool is expected to be highly useful in ensuring the objectivity of quantitative analyses. However, it is necessary to develop a PSS that is both standardized and tailored to the particular needs of each area. Finally, the development of an e-governance system will be beneficial in ensuring public access to the decision making process.

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Synthesis and Anticandidal Activity of Azole‐Containing Sulfonamides

Qandil

Hassan

Al-Shar’i

2008

Archiv der Pharmazie

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Twenty five benzenesulfonamides containing one imidazole or triazole ring, or two imidazole or triazole rings have been synthesized and evaluated as anticandidal agents. The most active compounds were 5c, 6b, 6c, 6e, and 17b, which exhibited MIC values of 4.55-24.39 mM depending on the clinical isolate. Comparing imidazole to triazole derivatives did not show a clear effect on activity. Compounds containing a N-benzyl group also showed no clear evidence on activity given the fact that they have an extra aromatic ring. Secondary sulfonamides, 5l, 5m, and 5n showed activities that were proportional to their lipophilicity. The activities of N-aryl-substituted derivatives 5j, 5k, 5l, 5m, 5n, and 6j were also proportional to their lipophilicity. Halogenation enhanced the activity as a result of improvement of lipophilicity. The presence of two imidazole or triazole rings in the same compound did not show a clear enhancement of activity.

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Arenesulfonylheterocycles (I): Synthesis and reactions of 2‐benzenesulfonyl‐4,5‐dichloropyridazin‐3‐ones with amines

Cited by 22 publications

References 8 publications

Recent Progress in the Chemistry of Pyridazinones for Functional Group Transformations

Recent Progress in the Chemistry of Pyridazinones for Functional Group Transformations

Planning Support Systems (PSS)-Based Spatial Plan Alternatives and Environmental Assessment

Synthesis and Anticandidal Activity of Azole‐Containing Sulfonamides

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