Arene ruthenium, rhodium and iridium complexes containing N∩O chelating ligands: synthesis, antibacterial and antioxidant studies

Lapasam, Agreeda; Shadap, Lathewdeipor; Tripathi, Dulal Krishna; Poluri, Krishna Mohan; Kaminsky, Werner; Kollipara, Mohan Rao

doi:10.1080/00958972.2021.1963439

Cited by 7 publications

(5 citation statements)

References 42 publications

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“…The antioxidant property of complex and the ligand was studied by Radical Scavenging Activity (RSA) toward DPPH, and the reactions were observed by employing a UV-Vis spectrophotometer (Tabrizi et al, 2019;Lewandowski et al, 2020;Lapasam et al, 2021).…”

Section: Antioxidant Activity In Vitromentioning

confidence: 99%

Radical scavenging capacity, antibacterial activity, and quantum chemical aspects of the spectrophotometrically investigated iridium (III) complex with benzopyran derivative

et al. 2022

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A comprehensive aqueous phase spectrophotometric study concerning the trace level determination of iridium (III) by its reaction with benzopyran-derived chromogenic reagent, 6-chloro-3-hydroxy-7-methyl-2-(2′-thienyl)-4-oxo-4H-1-benzopyran (CHMTB), is performed. The complexing reagent instantly forms a yellow complex with Ir (III) at pH 4.63, where metal is bound to the ligand in a ratio of 1:2 as deduced by Job’s continuous variations, mole ratio, and equilibrium shift methods. The complex absorbs maximally at 413–420 nm retaining its stability for up to 4 days. An optimum set of conditions have been set with respect to the parameters governing the formation of the complex. Under the set optimal conditions, the Ir (III)-CHMTB complex coheres to Beer’s law between 0.0 and 1.5 µg Ir (III) mL−1. The attenuation coefficient and Sandell’s sensitivity are, respectively, 1.18×105 L mol−1 cm−1 and 0.00162 μg cm−2 at 415 nm. The correlation coefficient (r) and standard deviation (SD) were 0.9999 and ± 0.001095, respectively, whereas the detection limit as analyzed was 0.007437 μg ml−1. The interference with respect to analytically important cations and complexing agents has been studied thoroughly. It is found that the majority of the ions/agents do not intervene with the formation of the complex, thus adding to the versatility of the method. The results obtained from the aforesaid studies indicate a simple, fast, convenient, sensitive, and versatile method for microgram analysis of iridium (III) using CHMTB as a binding ligand. Furthermore, the studied complex is subjected to the evaluation of antibacterial and antioxidant capacity by employing the Agar Diffusion assay and DPPH. radical scavenging method, respectively. The results obtained from the mentioned assays reveal that the investigated complex possesses significant potency as an antibacterial and antioxidant agent. Finally, the computational approach through DFT of the formed complex confirmed the associated electronic properties of the studied complex.

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Section: Antioxidant Activity In Vitromentioning

confidence: 99%

Radical scavenging capacity, antibacterial activity, and quantum chemical aspects of the spectrophotometrically investigated iridium (III) complex with benzopyran derivative

et al. 2022

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“…The absorbance at 517 nm was measured by using an ultraviolet–visible (UV–vis) spectrophotometer (Eppendorf, Germany). To quantify the percentage inhibition of DPPH radicals as an indicator of latex’s capability to neutralize reactive oxygen species (ROS), the following formula was used % radical scavenging activity = normalO normalD normalb lank − normalO normalD normals normala normalm normalp normall normale O D b lank × 100 where OD sample denotes the absorbance of the lattices and OD blank indicates the absorbance of the control reaction …”

Section: Materials and Methodsmentioning

confidence: 99%

“…To quantify the percentage inhibition of DPPH radicals as an indicator of latex’s capability to neutralize reactive oxygen species (ROS), the following formula was used where OD sample denotes the absorbance of the lattices and OD blank indicates the absorbance of the control reaction. 23 …”

Section: Materials and Methodsmentioning

confidence: 99%

Characterization, Antioxidant, and Antimicrobial Properties of Mulberry Lattices

Kumar R,

Gosipatala,

Kumar

et al. 2023

ACS Omega

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In order to find the most advantageous bioactive compounds from mulberry latex for drug development in the near future, this study was conducted to characterize and evaluate antioxidant and antimicrobial properties from four different mulberry lattices (BR-2, S-1, AR-14, and S-146). The characterization of the lattices was performed by scanning electron microscopy with energy-dispersive X-ray spectroscopy, gas chromatography coupled to mass spectroscopy, and Fourier transform infrared spectroscopy. Further, screenings of the antioxidant and antimicrobial potential of selected lattices were performed in vitro using 2,2-diphenyl-1-picrylhydrazyl assay and agar well diffusion methods, respectively. Interestingly, the outcome of the current study revealed that tested mulberry lattices contain a considerable amount of bioactive phytoconstituents, particularly antimicrobial and antioxidant compounds, as revealed by chromatographic analysis. BR-2 latex was found to have significant antioxidant activity (75%) followed by S-146 (64.6%) and AR-14 (52.9%). The maximum antimicrobial activity was found in BR-2 latex compared to other tested latex varieties. The results of this investigation showed that mulberry latex from the BR-2 type may successfully control both bacterial and fungal infections, with the added benefit of having enhanced antioxidant capabilities.

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“…This results in inflammation and delayed wound healing and causes damage to the adjacent tissues, which might cause sepsis and multiorgan failure. 5,6 Bacteria and fungi can form biofilms, but over the years, fungal biofilmassociated wound infections have been escalating, where Candida spp. are the leading fungal pathogens causing chronic wound infections.…”

Section: Introductionmentioning

confidence: 99%

“…The biofilm protects the microbial cells against the immune cells and is responsible for the recalcitrant behavior of inhabiting cells by restricting the penetration of the antimicrobial agent. This results in inflammation and delayed wound healing and causes damage to the adjacent tissues, which might cause sepsis and multiorgan failure. , Bacteria and fungi can form biofilms, but over the years, fungal biofilm-associated wound infections have been escalating, where Candida spp. are the leading fungal pathogens causing chronic wound infections .…”

Section: Introductionmentioning

confidence: 99%

Exploration of Antibiofilm and In Vivo Wound Healing Activity of p-Cymene-Loaded Gellan/PVA Nanofibers

Mishra

Gupta

Srivastava³

et al. 2023

ACS Appl. Bio Mater.

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Wound dressings with outstanding biocompatibility, antimicrobial, and tissue regeneration activities are essential to manage emerging recalcitrant antifungal infections to speed up healing. In this study, we have engineered p-cymene-loaded gellan/PVA nanofibers using electrospinning. Morphological and physicochemical properties of the nanofibers were characterized using a multitude of techniques to validate the successful integration of p-cymene (p-cym). The fabricated nanomaterials exhibited strong antibiofilm activity against Candida albicans and Candida glabrata compared to pure p-cymene. In vitro biocompatibility assay demonstrated that nanofibers did not possess any cytotoxicity to the NIH3T3 cell lines. In vivo, full-thickness excision wound healing study showed that the nanofibers were able to heal skin lesions faster than the conventional clotrimazole gel in 24 days without forming any scar. These findings unraveled p-cymene-loaded gellan gum (GA)/poly(vinyl alcohol) (PVA) nanofibers as an effective biomaterial for cutaneous tissue regeneration.

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Arene ruthenium, rhodium and iridium complexes containing N∩O chelating ligands: synthesis, antibacterial and antioxidant studies

Cited by 7 publications

References 42 publications

Radical scavenging capacity, antibacterial activity, and quantum chemical aspects of the spectrophotometrically investigated iridium (III) complex with benzopyran derivative

Radical scavenging capacity, antibacterial activity, and quantum chemical aspects of the spectrophotometrically investigated iridium (III) complex with benzopyran derivative

Characterization, Antioxidant, and Antimicrobial Properties of Mulberry Lattices

Exploration of Antibiofilm and In Vivo Wound Healing Activity of p-Cymene-Loaded Gellan/PVA Nanofibers

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