Arene-ruthenium(II) complexes with tetracyclic oxime derivatives: synthesis, structure and antiproliferative activity against human breast cancer cells

Matveevskaya, Vladislava V.; Pavlov, Dmitry I.; Самсоненко, Д. Г.; Bonfili, Laura; Cuccioloni, Massimiliano; Benassi, Enrico; Pettinari, Riccardo; Potapov, Аndrei S.

doi:10.1016/j.ica.2022.120879

Cited by 11 publications

(14 citation statements)

References 74 publications

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“…These results suggested the strength of the compounds' toxicity profiles and demonstrated their potential as anticancer agents. The data obtained indicate that the activity of ruthenium arene complexes was correlating with the literature 30,33,34 …”

Section: Resultssupporting

confidence: 85%

“…Preliminary data in the literature suggest that ruthenium compounds might be good candidate agents against cancer cells. [26][27][28][29] Studies over the year suggested that ruthenium has anticancer activity against various cancer cells including breast, 30 lung, 31 prostate, and ovarian cells. 13 In this study, eight different novel ruthenium complexes were synthesized and their anticancer potential against MCF-7 cells was studied.…”

Section: Pharmacology/biologymentioning

confidence: 99%

“…The data obtained indicate that the activity of ruthenium arene complexes was correlating with the literature. 30,33,34 Ru1, Ru4, and Ru5 complexes were used in our previous study. In this study, they were used both for further investigation and as a reference for the other new complexes.…”

Section: Pharmacology/biologymentioning

confidence: 99%

See 2 more Smart Citations

Ruthenium compounds: Are they the next‐era anticancer agents?

Kavukcu,

Özverel,

Kıyak

et al. 2024

Applied Organom Chemis

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This study focuses on the cytotoxic activity of ruthenium(II) complexes, denoted as Ru1–8, which exhibit coordination with nitrogen (amine and amide), oxygen, and sulfur donor atoms, coupled with aryl and aliphatic wingtips. Specifically, the complexes were evaluated for their impact on the MCF‐7 breast cancer cell line. A systematic exploration of various parameters, including solubility, donor atom type, metal number, carbon chain length, aromatic ring presence, and molecular weight, was conducted to discern their influence on cytotoxic activity. The investigation involved assessing the cell viability across five concentrations (100, 50, 25, 10, and 5 μM) for five distinct monometallic and three bimetallic ruthenium complexes. Notably, Ru3, characterized by an extended carbon chain length (dodecyl) and favorable oil solubility facilitating cellular membrane penetration, demonstrated particularly promising results with the IC50 value of 1.03 μM. This research underscores the critical role of ligand design in shaping the cytotoxic potential of ruthenium(II) complexes and emphasizes the suitability of the Ru(II) p‐cymene complexes, as demonstrated by their robust activity against breast cancer in this specific investigation.

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Section: Resultssupporting

confidence: 85%

Section: Pharmacology/biologymentioning

confidence: 99%

See 1 more Smart Citation

Ruthenium compounds: Are they the next‐era anticancer agents?

Kavukcu,

Özverel,

Kıyak

et al. 2024

Applied Organom Chemis

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“…[67][68][69] Oximes, vic-dioximes, and their metal complexes have attracted enormous interest from research groups worldwide because they are easily synthesizable by many different methods and their physical and chemical properties are devisable according to their application areas by using different substituents and metal salts. 68,70 These compounds have been employed in many fields of science with many application areas such as catalysis, 71,72 nanoparticles, 73,74 electrochemical sensors, [75][76][77] anti-chemical warfare agents, 76,78 anti-cancer [79][80][81] and anti-bacterial treatments. [82][83][84] Despite the wide usage of oximes in different areas, any notable studies had been working on in the field of energy storage about their properties.…”

Section: Introductionmentioning

confidence: 99%

High performance supercapacitive behaviors of oximes in a poly(aniline-co-pyrrole) based conducting polymer structure

et al. 2023

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“…Nevertheless, a limited number of metal complexes with oximate ligands have been reported in the literature using different transition and block f metals [ 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ]. Only two papers describing potassium complexes using oximate ligands have been published.…”

Section: Introductionmentioning

confidence: 99%

Ring-Opening Polymerization of L-Lactide Catalyzed by Potassium-Based Complexes: Mechanistic Studies

et al. 2022

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Two non-toxic potassium compounds, 1 and 2, with a commercial oximate ligand have been prepared and fully spectroscopically characterized. Their activity as catalysts for the ring-opening polymerization (ROP) process of LLA has been studied, showing that they are extremely active and able to polymerize the monomer in a few minutes. For derivative 2, the presence of a crown ether in the potassium coordination sphere affects the nuclearity of the compound and consequently its solubility, with both aspects having an influence in the polymerization process. Detailed studies of the polymerization mechanism have been performed, and an unusual anionic mechanism was observed in absence of a co-initiator. Indeed, the monomer deprotonation generates a lactide enolate, which initiates the polymerization propagation. On the contrary, when a 1:1 ratio of cat:BnOH is used, a mixture of mechanisms is observed, the anionic mechanism and the activated monomer one, while from a cat:BnOH ratio of 1:2 and over, only the activated monomer mechanism is observed.

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Arene-ruthenium(II) complexes with tetracyclic oxime derivatives: synthesis, structure and antiproliferative activity against human breast cancer cells

Cited by 11 publications

References 74 publications

Ruthenium compounds: Are they the next‐era anticancer agents?

Ruthenium compounds: Are they the next‐era anticancer agents?

High performance supercapacitive behaviors of oximes in a poly(aniline-co-pyrrole) based conducting polymer structure

Ring-Opening Polymerization of L-Lactide Catalyzed by Potassium-Based Complexes: Mechanistic Studies

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