Arenavirus nucleocapsid protein displays a transcriptional antitermination activity in vivo

Tortorici, M. Alejandra; Albariño, César G.; Posik, Diego Manuel; Ghiringhelli, Pablo Daniel; Lozano, Mario Enrique; Pomar, Rolando Rivera; Romanowski, Vı́ctor

doi:10.1016/s0168-1702(00)00222-7

Cited by 50 publications

(51 citation statements)

References 29 publications

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“…Among the N described motifs, there is one RING finger domain whose folding requires zinc (Tortorici et al, 2001b). There is one conserved region between amino acids 497 and 530 (C 497 X 2 H 500 X 23 C 525 X 4 C 530 , Parisi et al, 1996) and their function was experimentally studied (Tortorici et al, 2001b). These results confirm the identity of the domain and also The major ORF in the virus genome corresponds to the RNA dependent RNA polymerase denominated L protein.…”

Section: Molecular Features Of Arenavirusesmentioning

confidence: 67%

“…Furthermore, some changes in the structural proteins, nucleoprotein and both mature glycoproteins, could be related with the attenuation of virulence. The carboxyl-terminus of N protein, which contains a zinc binding domain (Tortorici et al, 2001b) is highly conserved, and the found N 47 change (VVE) falls outside this region and would be associated with another characteristic of the protein, as the ability to oligomerize (N-N interactions, Levingston Macleod et al, 2011). Therefore, N protein has a dual function during the virus life cycle.…”

Section: Discussionmentioning

confidence: 99%

“…The intergenic region in both genomic fragments is arranged into a stable hairpin loop structure, which is crucial in the regulation between transcription and replication of the viral genome (Tortorici et al, 2001b), while the panhandle structure at the ends of the genomic RNAs, could act as a promoter initiating replication, as occurs in Flavivirus (Álvarez et al, 2005;Salvato & Shimomaye, 1989).…”

Section: Molecular Features Of Arenavirusesmentioning

confidence: 99%

“…For that, the determinations of N-RNA interactions are very interesting study targets. Among the N described motifs, there is one RING finger domain whose folding requires zinc (Tortorici et al, 2001b). There is one conserved region between amino acids 497 and 530 (C 497 X 2 H 500 X 23 C 525 X 4 C 530 , Parisi et al, 1996) and their function was experimentally studied (Tortorici et al, 2001b).…”

Section: Molecular Features Of Arenavirusesmentioning

confidence: 99%

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Molecular Attenuation Process in Live Vaccine Generation for Arenaviruses

Goñi¹,

Lozano²

2012

Point Mutation

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Section: Molecular Features Of Arenavirusesmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Section: Molecular Features Of Arenavirusesmentioning

confidence: 99%

Section: Molecular Features Of Arenavirusesmentioning

confidence: 99%

See 2 more Smart Citations

Molecular Attenuation Process in Live Vaccine Generation for Arenaviruses

Goñi¹,

Lozano²

2012

Point Mutation

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“…The two ORFs in each segment are separated by an intergenic noncoding region (IGR) that could form one or more energetically stable stem-loop (hairpin) structures [9,143]. The IGR functions in structure-dependent transcription termination [96,97,132] and in virus assembly and/or budding [111].…”

Section: Introductionmentioning

confidence: 99%

Past, present, and future of arenavirus taxonomy

et al. 2015

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Until recently, members of the monogeneric family Arenaviridae (arenaviruses) have been known to infect only muroid rodents and, in one case, possibly phyllostomid bats. The paradigm of arenaviruses exclusively infecting small mammals shifted dramatically when several groups independently published the detection and isolation of a divergent group of arenaviruses in captive alethinophidian snakes. Preliminary phylogenetic analyses suggest that these reptilian arenaviruses constitute a sister clade to mammalian arenaviruses. Here, the members of the International Committee on Taxonomy of Viruses (ICTV) Arenaviridae Study Group, together with other experts, outline the taxonomic reorganization of the family Arenaviridae to accommodate reptilian arenaviruses and other recently discovered mammalian arenaviruses and to improve compliance with the Rules of the International Code of Virus Classification and Nomenclature (ICVCN). PAirwise Sequence Comparison (PASC) of arenavirus genomes and NP amino acid pairwise distances support the modification of the present classification. As a result, the current genus Arenavirus is replaced by two genera, Mammarenavirus and Reptarenavirus, which are established to accommodate mammalian and reptilian arenaviruses, respectively, in the same family. The current species landscape among mammalian arenaviruses is upheld, with two new species added for Lunk and Merino Walk viruses and minor corrections to the spelling of some names. The published snake arenaviruses are distributed among three new separate reptarenavirus species. Finally, a non-Latinized binomial species name scheme is adopted for all arenavirus species. In addition, the current virus abbreviations have been evaluated, and some changes are 123Arch Virol (2015) 160:1851-1874 DOI 10.1007/s00705-015-2418 introduced to unequivocally identify each virus in electronic databases, manuscripts, and oral proceedings.

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