Arecanut (Areca catechu L.) seed extracts extracted by conventional and eco-friendly solvents: Relation between phytochemical compositions and biological activities by multivariate analysis

Antioxidant and Anti-Skin Aging Potential of Selected Thai Plants: In Vitro Evaluation and In Silico Target Prediction

“…However, in contrast to the binding of the compound with elastase, the identified potential compounds against tyrosinase are from a variety of phytochemical classes. Regarding the rank of binding energies towards tyrosinase, the compounds that are considered the best five inhibitors are o-Coumaric acid [ 30 ] (phenolic), tetramer of proanthocyanidin [ 25 ] (flavonoid), caffeic acid [ 30 ] (phenolic), ferulic acid [ 30 ] (phenolic), and arecatannin A1 [ 31 ] (tannin), in the increasing order of scores ( Table S5 ). The results obtained from in vitro screening and docking analysis in this study have confirmed the anti-skin-aging properties of four Thai medicinal plants and suggested their potential derived compounds that could be responsible for the observed activities.…”

“…A list of phytochemical compounds from the three most effective plants with strong inhibition against elastase or tyrosinase was selected from the published literature [ 25 , 26 , 27 , 28 , 30 , 31 , 32 , 42 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 ] ( Table S3 ). All chemical structures of the compounds were generated from the IUPAC name using BIOVIA Draw 2019 (BIOVIA, San Diego, CA, USA).…”

“…The following supporting information can be downloaded at: , Figure S1: correlation analysis between phytochemical contents and antioxidant capacities among the studied plants; Table S1: the percent inhibition of elastase activity by Thai plants at various concentrations; Table S2: the percent inhibition of tyrosinase activity by Thai plants at various concentrations; Table S3: list of compounds derived from three most effective plants on inhibition against elastase and/or tyrosinase; Table S4: molecular docking results between phytochemical compounds and the binding site of elastase (3HGP); Table S5: molecular docking results between phytochemical compounds and the binding site of tyrosinase (2Y9X). References [ 25 , 26 , 27 , 28 , 30 , 31 , 32 , 42 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 ] are cited in the Supplementary Materials.…”

Fermentative extraction of phenolic compounds from unripe areca nuts by solid‐state fermentation using newly isolated Rhizopus orizaeMW538932

“…Phenolic compounds are the most important and widely available natural antioxidants that can replace synthetic antioxidants and consequently help to reduce harmful and carcinogenic effects of free radicals (Selamoglu, 2017). Areca nut seeds (pericarp of Areca catechu L.) are a rich source of natural antioxidants due to the abundance of phenolic acids, tannins, and flavonoids (Wang et al ., 2021). Areca nut has been traditionally used in the ancient Indian system of Ayurveda and Chinese medical practices for centuries (Salehi et al ., 2020).…”

Phytochemical extraction and comparative analysis of antioxidant activities of Areca catechu L. nut extracts

“…Ancient medicines like Ayurveda and Siddha used areca nut as one of the ingredients in oils for healing wounds by burning (Verma et al 2012). It is one of the most commonly used drugs in the world that have anthelmintic, antibacterial, antifungal, anti-inflammatory, and antioxidant activities (Wang et al 2001). The WHO has pointed out nearly 25 useful effects of Areca catechu and also reported that all the alkaloids present in it showed medicinal properties (Bhat et al 2017).…”