Area under curve of temporal estradiol measurements for prediction of the detrimental effect of estrogen exposure on implantation

Kutlu, Tayfun; Özkaya, Enis; Ayvaci, Habibe; Devranoğlu, Belgin; Sanverdi, Ilhan; Şahin, Yavuz; Şenol, Taylan; Karateke, Ateş

doi:10.1016/j.ijgo.2016.04.015

Cited by 16 publications

(9 citation statements)

References 21 publications

(22 reference statements)

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“…This was observed in several studies, who found the lower implantation rate in high estradiol level condition during IVF ET cycle [10] [14] [15]. However, the difference in pregnancy results was not the primary goal of this study.…”

Section: Discussionmentioning

confidence: 51%

“…Kutlu et al conducted a study to evaluate whether the AUC of E2 might be used as a predictor of clinical pregnancy or implantation failure. They found that there was a significant difference between AUC of E2 in women with successful implantation and those whose implantation was failed [10]. They concluded that the AUC of E2 might be used for predicting implantation success.…”

Section: Discussionmentioning

confidence: 99%

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The Comparison of Area under the Curve of Serum Estradiol during Controlled Ovarian Stimulation between Long Gonadotrophin Releasing Hormone Agonist Protocol and Short Gonadotrophin Antagonist Protocol in Invitro Fertilization

Bayuaji¹,

Permadi²,

Sastramihardja³

et al. 2017

OALib

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Background: during stimulation, estradiol levels represent the dynamic hormonal interaction of follicle development. Some studies have been done to evaluate the influence of day-hCG estradiol assay and IVF outcome. However, this assay does not reflect the total exposure of estradiol throughout stimulation. Hence the concept of calculating the area under the curve (AUC) of estradiol during ovarian stimulation is thought to be a better parameter to evaluate total exposure of estradiol to the entire process of IVF. Methods: a retrospective analysis of data from a fertility center in a tertiary hospital. Between 2011-2016, there were long GnRH agonist cycles and short GnRH antagonist cycles eligible for analysis. Data including subject's characteristics, the level of estradiol on day-2, day-6, and day-hCG during controlled ovarian stimulation were obtained. Those data were plotted, and area under the curve of each subject was calculated. Statistical analysis was done using student t-test while p < 0.05 was considered significant. Results: there were no significant differences in subject's age (33.4 vs. 34.2 years, p = 0.12), day-3 of menstrual cycle FSH level (7.1 vs. 7.3 mIU/mL, p = 0.64), and day-3 estradiol level (35.1 vs. 36.5 pg/mL, p = 0.61). The estradiol level on day-5 of COS was How to cite this paper: Bayuaji, H., Permadi, W., Sastramihardja, H.S. and Nataprawira, H.M.N. (2017)

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Section: Discussionmentioning

confidence: 51%

Section: Discussionmentioning

confidence: 99%

The Comparison of Area under the Curve of Serum Estradiol during Controlled Ovarian Stimulation between Long Gonadotrophin Releasing Hormone Agonist Protocol and Short Gonadotrophin Antagonist Protocol in Invitro Fertilization

Bayuaji¹,

Permadi²,

Sastramihardja³

et al. 2017

OALib

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“…18 In our previous publication, we showed the significant value of the degree of endometrial estrogen exposure to predict implantation failure. 19 All these data show us that premature progesterone increase is a secondary finding of hyperstimulation and the degrees of hyperstimulation and high E2 causing impaired endometrial receptivity are better predicted by AUCEM.…”

Section: Discussionmentioning

confidence: 89%

Area under the curve of temporal estrogen and progesterone measurements during assisted reproductive technology: Which hormone is the main determinant of cycle outcome?

Özkaya

Kutlu

Yayla

et al. 2017

J of Obstet and Gynaecol

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“…This role of P4 is important in the establishment of pregnancy through the promotion of endometrial receptivity of the blastocyst and attachment of the trophoblast by suppression of deleterious maternal immune responses [15, 16]. Studies have used the area under curve of temporal progesterone measurements (AUCPM) on the implantation of embryos and thus clinical pregnancy in assisted reproductive technology (ART) in women [1, 17]. Other studies have also used the quantity of P4 to predict the probability of pregnancy in cattle [1, 18].…”

Section: Introductionmentioning

confidence: 99%

Characterization of Oestrus Cycles in Namibian Swakara and Damara Sheep through Determination of Circannual Plasma Progesterone Levels

Kandiwa

Mushonga

Madzingira

et al. 2019

Journal of Veterinary Medicine

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A year-long prospective study characterized the seasonality of oestrus cycles in primiparous, nonpregnant Swakara (n=8) and Damara (n=5) ewes through surveillance of plasma progesterone (P4) levels. During this period, Swakara and Damara groups evidently averaged 23 oestrus cycles with an average length of 17 days. Damara ewes showed greater mean peak plasma P4 levels (11.4±0.16ng/ml) than Swakara ewes (5.4±0.11ng/ml) (P<0.05). Oestrus cycles in Damara ewes showed relatively uniform plasma P4 peaks throughout the year ranging from 10.6±0.16 to 12.6±0.24ng/ml. In Swakara ewes, P4 peaks were highest in the autumn oestrus cycles (from 7.1±0.16 to 7.5±0.11ng/ml), rapidly declining through winter to 2.2±0.08ng/ml by midspring and then rapidly increasing to 4.9±0.37ng/ml at the commencement of summer, followed by a gradual increase from 5.7± to 7.1±ng/ml by the start of autumn. The annual mean area under the curve temporal progesterone measurements (AUCPM) in Damara ewes (115.9±18.6ng⁎day/ml) was greater than that in Swakara ewes (58.6±25.3ng⁎day/ml) (p<0.05). For Swakara ewes, the mean AUCPM in summer and autumn cycles (68.2±14.7 and 79.5±10.0ng⁎day/ml, respectively) were greater than those in spring and winter cycles (28.7±12.3 and 55.0±27.3ng⁎day/ml), respectively (P<0.05). There was no seasonal variation in the exposure of the Damara ewes to P4 in between seasons (P>0.05), though, however, the Damara ewes had greater P4 levels than the Swakara ewes (P<0.05). Progesterone profiles showed that Swakara ewes possessed ‘residual’ seasonality, whereas the Damara ewes were no longer seasonal. The implications of this disparity in the seasonal exposure of Swakara and Damara ewes to luteal P4 on fertility warrant further investigation.

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Area under curve of temporal estradiol measurements for prediction of the detrimental effect of estrogen exposure on implantation

Abstract: The area under the curve of estradiol measurements during ART cycles might be useful for predicting failure of implantation and clinical pregnancy.

Cited by 16 publications

References 21 publications

The Comparison of Area under the Curve of Serum Estradiol during Controlled Ovarian Stimulation between Long Gonadotrophin Releasing Hormone Agonist Protocol and Short Gonadotrophin Antagonist Protocol in Invitro Fertilization

The Comparison of Area under the Curve of Serum Estradiol during Controlled Ovarian Stimulation between Long Gonadotrophin Releasing Hormone Agonist Protocol and Short Gonadotrophin Antagonist Protocol in Invitro Fertilization

Area under the curve of temporal estrogen and progesterone measurements during assisted reproductive technology: Which hormone is the main determinant of cycle outcome?

Characterization of Oestrus Cycles in Namibian Swakara and Damara Sheep through Determination of Circannual Plasma Progesterone Levels

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