Area-specific economic status should be regarded as a vital factor affecting the occurrence, development and outcome of cervical cancer

Abstract

For patients with cervical cancer, despite the incidence and mortality rates have been declining in recent years, due to its huge population base, cervical cancer has always been a serious public health problem. Our research placed emphasis on the indices greatly associated with overall area-specific social economic status, making up for the defects of traditional research which only pay attention to the situation of some specific disease or patients' individual social status. A total of 39160 women identified cervical cancer were concluded in our study from the Surveillance, Epidemiology, and End Results (SEER) 18 Program data between 1980 and 2014. With improving the area-specific social economic factors in recent years, the occurrence and prognosis of cervical cancer showed different variation patterns respectively. Some states like California and Georgia for their better economic status and more healthcare investment by local medical institution, population there showed a lower prevalence, incidence, more timely diagnosis, effective treatment, and better prognosis. According to our study, we aimed to give a scientific interpretation on how the area-specific social economic factors affect the disease situation at the macro level and help local medical institution make advisable decisions for controlling cervical cancer.Cervical cancer is the fourth most frequent diagnosed cancer type 1 and the third leading cause of cancer deaths among females in the world. In United States, it was also regarded as an important public health problem, for nearly 250,000 women currently live with the cervical cancer 2 , 12,820 new cases' occurrence and 4,210 patients' deaths annually 3 .With the progress in research targeting to cervical cancer, infection of the Human Papilloma virus (HPV) was confirmed as a vital etiologic risk factor of cervical cancer. Due to the promotion of first screening, the incidence and the mortality rates decreased gradually though early intervention and reduction of the risk factors 4 . As a result, cervical cancer became a preventable disease in general population.In recent years, more and more women got benefits from medical development under the support by local economic institution, for spreading HPV vaccine since 2006 4 and applying many advanced treatment gradually. However, in some underdeveloped areas, most women still suffered undiagnosed and had limited access to proper treatment or prevention in their daily life 5-8 . These differences might derive from many aspects. According to previous studies, variation of patients' incidence rates and outcome have been greatly associated with ages, tumor histology, tumor differentiation 7,9,10 , and individual socioeconomic status, including race/ethnicity and insurance status [11][12][13] . However, the overall social economic factors have been ignored, which may be greatly associated

Novel Role of IMPA2 in AIFM2-Mediated Apoptosis of Cervical Cancer by Targeting p53

“…The percentage of positive cells was divided into ve score ranks: <10% (0), 10-25% (1), 25-50% (2),50-75% (3), and >75% (4). The intensity of staining was divided into four score ranks: no staining (0), light brown (1), brown (2), and dark brown (3). Two different pathologists evaluated all the specimens in a blinded manner.…”

“…Cervical cancer is a common health problem that seriously threatened women's health worldwide, with approximately 12,820 new cases and 4,210 deaths per year in the US (1,2). Radiotherapy and chemotherapy are still the two main treatments for cervical cancer.…”

IMPA2 blocks cervical cancer cell apoptosis and induces paclitaxel resistance through p53-mediated AIFM2 regulation

“…Cervical cancer is a common health problem that seriously threatens women’s health worldwide, with approximately 12,820 new cases and 4210 deaths per year in the US [ 1 , 2 ] . Radiotherapy and chemotherapy are still the two main treatments for cervical cancer.…”

Development of a Novel Deep Learning-Based Prediction Model for the Prognosis of Operable Cervical Cancer

“…SEER registers have been collecting demographic and clinicopathological data of cancer patients since 1973. Various studies have used the SEER dataset to perform survival analyses for different types of cancers, including cervical cancer [9][10][11]. However, nearly all of these studies used the Cox proportional hazard (CPH) model for analyses.…”