Area-dependent changes in GABAergic function after acute and chronic cold stress

Acosta, Gabriela Beatriz; Losada, Matilde E. Otero; Rubio, Modesto C.

doi:10.1016/0304-3940(93)90200-5

Cited by 55 publications

(32 citation statements)

References 18 publications

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“…Earlier studies reported that GABA, either intraperitoneally or infused into the MBH, blunts thyrotropic re sponse to cold [47], Moreover, GABAergic transmission seems affected by cold exposure, since 3H-GABA uptake in the hypothalamus decreases after cold exposure [48], Elevation of cyclic GMP levels in several brain regions under cold stress is mimicked by GABAergic drugs. GABA antagonists however do not modify basal TSH secretion by themselves and do not antagonize either GABA inhibition of the TSH response to cold [47], Since GABA has no effect on TRH release in vitro, we postulated that SRIH neurons could be a target of GABA effects on basal and cold-stimulated TSH secretion.…”

Section: Gabamentioning

confidence: 99%

“…A possible explanation is that GABA has a differ ent effect on TSH secretion under basal or cold-stimulat ed conditions. Under basal conditions, picrotoxin can blunt GABA inhibition of SRIH release, thus increasing SRIH release from the ME [51] and decreasing plasma TSH [39], In contrast, decreased TSH release observed after GABA administration could be due to a pituitary action of GABA to inhibit TRH-induced TSH release in vitro [52], The peripheral site may be predominant when GABA is administered peripherally, but not intraventricularly, a condition under which it does not affect coldstimulated TSH secretion [47], Cold exposure activates an endogenous GABA tone [48], thus inhibiting SRIH release and enhancing TSH secretion. Picrotoxin could prevent GABAergic inhibi tion of SRIH, and consequently increase TSH release, whereas systemic GABA could inhibit TSH secretion.…”

Section: Gabamentioning

confidence: 99%

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Neuroendocrine and Autonomous Mechanisms Underlying Thermoregulation in Cold Environment

et al. 1996

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This review focuses on the central regulation of thermoregulatory responses with special attention to the participation of thyrotropin-releasing hormone (TRH) in both autonomous and endocrine responses to a cold environment. Besides a direct projection of TRH neurons from paraventricular nuclei (PVN) to the median eminence, and the subsequent activation of the thyroid axis, there are direct projections from the PVN to the autonomic preganglionic neurons controlling autonomous responses. These projections convey information to peripheral targets involved in thermogenesis through the dorsal vagal complex and the spinal cord, for parasympathetic and sympathetic neurotransmissions respectively. Furthermore, cold exposure increases TRH mRNA levels in the PVN but also in dorsal motor and caudal raphe nuclei, thus providing strong evidence for a functional link between autonomous and neuroendocrine systems involved in thermoregulation.

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Section: Gabamentioning

confidence: 99%

Section: Gabamentioning

confidence: 99%

Neuroendocrine and Autonomous Mechanisms Underlying Thermoregulation in Cold Environment

et al. 1996

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“…Post-hoc analysis of the effects of strain, collapsed across stress condition, showed that no strain significantly differed from another ( Figure 2). Previous studies have found inconsistent effects of various stress procedures on EtOH selfadministration in rats and mice [1,10,32,33,41,47,49,55,[59][60][61][62]. Similarly, work examining the effects of stress on sensitivity to the behavioral effects of acute EtOH challenge has not produced a clear consensus [7,16,20,21,26,34,45,48].…”

mentioning

confidence: 99%

Effects of chronic swim stress on EtOH-related behaviors in C57BL/6J, DBA/2J and BALB/cByJ mice

Boyce-Rustay

Janos

Holmes

2008

Behavioural Brain Research

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There is a strong clinical relationship between stress and stress-related disorders and the incidence of alcohol abuse and alcoholism, and this relationship appears to be partly genetic in origin. There are marked strain differences in ethanol (EtOH)-related behaviors and reactivity to stress, but little investigation of the interaction between the two. The present study assessed the effects of chronic exposure to swim stress on EtOH-related behavior in three common inbred strains of mice, C57BL/ 6J, DBA/2J and BALB/cByJ. After establishing baseline (10%) EtOH self-administration in a twobottle free choice test, mice were exposed to daily swim stress for 14 consecutive days and EtOH consumption measured as a percent of baseline both during stress and for 10 days afterwards. A separate experiment examined the effects of 14 days of swim stress on sensitivity to the sedative/ hypnotic effects of an acute injection of 4 g/kg EtOH. Results showed that stress produced a marked and prolonged decrease in EtOH consumption in DBA/2J and BALB/cByJ, but not C57BL/6J mice. By contrast, stress increased sensitivity to the sedative/hypnotic effects of EtOH across all 3 strains. These findings demonstrate that chronic swim stress produces reductions in EtOH self-administration in a strain-dependent manner, and that these effects may be restricted to low-consuming strains. Present data also indicate a dissociation between effects of this stressor on EtOH self-administration and sensitivity to EtOH's sedative/hypnotic effects. In conclusion, strain differences, that are likely in large part genetic in nature, modify the effects of this stressor on EtOH's effects in a behaviorspecific manner. Keywords mouse; strain; ethanol; sedation; gene; drinking; swim stress; preference; two-bottle choice There is a strong epidemiological link between stress-related psychiatric disorders and alcoholism. Individuals suffering from depression or anxiety disorders, conditions often associated with stress, are more likely to abuse alcohol and become alcoholic, and tend to respond less well to therapeutic interventions [8,9,29,54]. Moreover, a history of adverse life events positively correlates with increased rates of alcoholism; although, interestingly, a proportion of individuals become abstinent following stress [19,35,46,51]. These clinic data lend support to the influential hypothesis that stress represent a significant risk factor for alcoholism [12,28]. *Corresponding author: R4N5 AP9A-L018, Abbott Laboratories, 100 Abbott Park Rd, Abbott Park, IL 60064, Ph. +1-847-937-2559, Fax +1-847-938-0072, E-mail: janel.boyce-rustay@abbott.com. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered wh...

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“…firstly, because the GABA-A receptor linked to a Cl-channel is involved in the inhibitory control of somatostatin release (Gamse et al, 1980;Arancibia & Briozzo, 1990;Rage et al, 1992) and synthesis (Rage et al, 1993); secondly, the release of this neurotransmitter is rapidly activated under cold exposure (Arancibia et al, 1995), and GABA levels in the synaptic cleft are increased by cold exposure (Acosta et al, 1993). Moreover, the involvement of GABA is in accordance with the fact that different acute stressors can diminish (Biggio et al, 1987) or potentiate (Schwartz et al, 1987) the GABA-A receptor function.…”

Section: Stress and Ovarian Hormone Interactionsmentioning

confidence: 83%

<b>Neurotrophins in Neuroendocrine Control: Brain Derived-neurotrophic Factor (BDNF) and Somatostatin Involvement in the Stress Response and Reproductive Physiology <b/>

Arancibia¹,

Rage²,

Givalois³

et al. 2006

Annu Rev Biomed Sci

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Area-dependent changes in GABAergic function after acute and chronic cold stress

Cited by 55 publications

References 18 publications

Neuroendocrine and Autonomous Mechanisms Underlying Thermoregulation in Cold Environment

Neuroendocrine and Autonomous Mechanisms Underlying Thermoregulation in Cold Environment

Effects of chronic swim stress on EtOH-related behaviors in C57BL/6J, DBA/2J and BALB/cByJ mice

<b>Neurotrophins in Neuroendocrine Control: Brain Derived-neurotrophic Factor (BDNF) and Somatostatin Involvement in the Stress Response and Reproductive Physiology <b/>

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