Are working memory and glutamate concentrations involved in early‐life stress and severity of psychosis?

Corcoran, Mark; Hawkins, Emma L.; O’Hora, Denis; Whalley, Heather C.; Hall, Jérémy; Lawrie, Stephen M.; Dauvermann, Maria R.

doi:10.1002/brb3.1616

Cited by 10 publications

(12 citation statements)

References 99 publications

(201 reference statements)

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“…Five studies [93][94][95][96][97] reported findings on the association between the frequency of CT and positive symptom severity (Table 4). An additional study focused on severity of delusions 98 in a large BD sample.…”

Section: Childhood Trauma and Mood And Psychotic Symptomsmentioning

confidence: 99%

“…Different CT scores were used across studies, ranging from a total CT score 93,[95][96][97] to scores for subtypes of CT (for example, physical neglect). 93 None of the five studies reported a significant correlation with total CT scores in individuals with first-episode or chronic BD. However, increased severity of delusions was associated with increased total CT scores.…”

Section: Childhood Trauma and Mood And Psychotic Symptomsmentioning

confidence: 99%

“…Importantly, both significant findings by Garcia et al were for females only. 96 Four studies reported correlational findings on the relationship between total CT score, or on at least one subtype of CT, and severity of negative symptoms 93,[95][96][97] (Table 5). These studies found weak correlations with only one reaching statistical significance in individuals with firstepisode BD.…”

Section: Childhood Trauma and Mood And Psychotic Symptomsmentioning

confidence: 99%

“…110 Finally, a Proton Magnetic Resonance Spectroscopy study showed that exposure to CT was associated with decreased glutamate concentrations in the left DLPFC in healthy individuals, but not in a mixed group of individuals with BD or SZ. 93…”

Section: Childhood Trauma and Brain Alterationsmentioning

confidence: 99%

“…106,107 These results are in contrast with other studies reporting no significant impact of trauma on cognitive performance. 93,[108][109][110] One reason may include the confounding effects of IQ levels, 111 which are sensitive to CT exposure. 103,112 Social cognitive skills are also affected by the experience of CT. 113 Females with BD exposed to emotional abuse performed better than trauma-exposed males to an emotional decision-making task and scored higher than abused males to an affective go/no-go task.…”

mentioning

confidence: 99%

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<p>The Impact of Childhood Trauma on Developing Bipolar Disorder: Current Understanding and Ensuring Continued Progress</p>

Quidé¹,

Tozzi²,

Corcoran³

et al. 2020

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Childhood trauma (CT) has been repeatedly linked to earlier onset and greater severity of bipolar disorder (BD) in adulthood. However, such knowledge is mostly based on retrospective and cross-sectional studies in adults with BD. The first objective of this selective review is to characterize the short-term effects of CT in the development of BD by focusing on studies in young people. The second objective is to describe the longer-term consequences of CT by considering studies with adult participants. This review first outlines the most prominent hypotheses linking CT exposure and the onset of BD. Then, it summarizes the psychological and biological risk factors implicated in the development of BD, followed by a discussion of original studies that investigated the role of CT in young people with early-onset BD, youths at increased risk of developing BD, or young people with BD with a focus on subclinical and clinical outcome measures. The review considers additional biological and psychological factors associated with a negative impact of CT on the long-term course of BD in later adulthood. Finally, we discuss how the integration of information of CT can improve ongoing early identification of BD and mitigate severe clinical expression in later adulthood.

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