Are we out of the infancy of microalgae-based drug discovery?

Savio, Saverio; Congestri, Roberta; Rodolfo, Carlo

doi:10.1016/j.algal.2020.102173

Cited by 10 publications

(4 citation statements)

References 44 publications

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“…Os desafios na aplicação de compostos bioativos de algas estão relacionados com as formas de extração de componentes funcionais, devido ao custo elevado de energia e produção, muitas vezes sendo necessário a aplicação de tecnologias emergentes para o processo extrativo, como exemplo: o uso de extrações assistidas por ultrassom, extrações com micro-ondas ou líquidos pressurizados, entre outros. Nesse sentido, surge a necessidade de desenvolver processos com baixo custo, tais problemas podem ser superados através de estudos científicos para novos processos visando sempre uma melhor viabilidade econômica (JHA et al, 2017;SAVIO et al, 2021).…”

Section: Desafios Na Aplicabilidadeunclassified

“…Logo, a falta de informação sobre a ecologia, fisiologia e os diferentes cultivos microalgais é um fator crítico, principalmente quando não há informações concretas sobre o metabólito responsável pela bioatividade observada para novos medicamentos e devido à falta de informações sobre os genomas e mecanismo de regulação gênica de compostos bioativos em algas, ainda existem grandes restrições e limitações que impedem o desenvolvimento deste tipo de pesquisa (SAVIO et al, 2021;WANG et al, 2017).…”

Section: Desafios Na Aplicabilidadeunclassified

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Potencial das microalgas na indústria farmacêutica

Mesadri¹,

Wagner²,

Fagundes³

2021

Microalgas: Potenciais Aplicações E Desafios

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Section: Desafios Na Aplicabilidadeunclassified

Potencial das microalgas na indústria farmacêutica

Mesadri¹,

Wagner²,

Fagundes³

2021

Microalgas: Potenciais Aplicações E Desafios

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“…The combination of adaptability to changes in environmental conditions and high growth rates has led to a recent advancement in the knowledge of intensive diatom cultivation for biotechnology purposes. This advancement takes advantage of both cellular biochemistry and frustule porous characteristics (aquafeed field, nutraceutics and pharmaceutics, nanotechnology and biomimetics) (Lamastra et al, 2014;Gilbert-Loṕez et al, 2017;Kiran Marella et al, 2020;Savio et al, 2021). Technological exploitation of the nanoporous structure of frustules has been further advanced by methods that modify frustules while maintaining its hierarchical structures.…”

Section: Introductionmentioning

confidence: 99%

Functionalization of Frustules of the Diatom Staurosirella pinnata for Nickel (Ni) Adsorption From Contaminated Aqueous Solutions

et al. 2022

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The structural characteristics of diatom cell walls (frustules) has led to their widespread use in diverse biotechnological applications, some of which can be further improved by surface chemical modification (functionalization). The use of coating agents can significantly increase surface binding capacity for target compounds. Frustules of the diatom Staurosirella pinnata used here were a by-product after applying a cascade-extraction process (for other products) to mass cultures. The protocol for the cleaning and functionalization of raw frustules using 3-Mercaptopropyl-trimethoxysilane and 3-Aminopropyl-trimethoxysilane was optimized and reported. Functionalization efficacy was observed using Electron Microscopy, Energy Dispersive X-ray Spectroscopy and Fourier-Transform Infrared Spectroscopy. Optimally functionalized frustules were evaluated for nickel removal from aqueous solutions. Incubations of 10 min, using 1 g/L of frustules, gave almost complete Ni removal with functionalized frustules compared to 3% removal by raw frustules. The proposed protocol represents a reproducible and efficient alternative for Ni removal from contaminated water.

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“…21 Microalgae-based drug discovery studies are a very new field of study. 22 There is no article for investigation of the drug interaction with Scenedesmus sp.…”

mentioning

confidence: 99%

Fast, Cheap and Reliable Monitoring of Microalgae-Based Paracetamol Removal from Aquatic Environment Using Electrochemical Sensor Technology

Çongur¹,

Gül²,

Taştan³

2022

J. Electrochem. Soc.

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Paracetamol (PRL) is an analgesic and antipyretic drug, and its consumption has increased all across the world during the COVID-19 pandemic era. However, its excessive consumption makes it an endocrine-disrupting factor, and it is toxic for the liver. It easily contaminates water resources due to its high solubility, and has substantial potential to access both aquatic life and humans. Therefore, its removal by sustainable methods is a highlighted issue for today’s world that has experienced increasing scarcity of water. Herein, microalgae-based PRL removal and its electrochemical monitoring were performed. The removal performed with Scenedesmus sp. was monitored by disposable pencil graphite electrodes and cyclic voltammetry. The removal was achieved without the requirement of complex procedures, and the monitoring of this removal finished in less than 1 min. Application of the system in real life was tested in the presence of tap water. The biosorption kinetics, isoterms, and changes in chlorophyll content of microalgae were calculated, and the microscopic characterizations of the biosorption were performed. The selectivity of the system was studied against other water contaminants. This is the first study about the removal of PRL using Scenedesmus sp. and the monitoring of the removal using disposable electrochemical sensor technology.

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Are we out of the infancy of microalgae-based drug discovery?

Cited by 10 publications

References 44 publications

Potencial das microalgas na indústria farmacêutica

Potencial das microalgas na indústria farmacêutica

Functionalization of Frustules of the Diatom Staurosirella pinnata for Nickel (Ni) Adsorption From Contaminated Aqueous Solutions

Fast, Cheap and Reliable Monitoring of Microalgae-Based Paracetamol Removal from Aquatic Environment Using Electrochemical Sensor Technology

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