Are we ignoring diabetic disability: A cross sectional study of diabetic myopathy

Nahar, Pradeep; Buge, Kiran; Vaidya, Sagar A.; Shah, Swati; Sonawane, Pranali

doi:10.4103/0019-5359.106609

Cited by 10 publications

(1 citation statement)

References 17 publications

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“… 8 The grip strength and endurance of the upper limbs also decrease in diabetic patients, causing disability and much compromise in life quality. 12 Not surprisingly, patients with T2DM are at greater risk of developing sarcopenia, as shown by several studies from different countries. 13 , 14 The mechanisms underlying this link have been reviewed elsewhere.…”

Section: Prevalence and Pathophysiological Characteristics Of Sarcopenia In Diabetic Patientsmentioning

confidence: 95%

Anti‐diabetic drugs and sarcopenia: emerging links, mechanistic insights, and clinical implications

Zhang

Zhao

Chen

et al. 2021

J cachexia sarcopenia muscle

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Sarcopenia, characterized by loss of skeletal muscle mass, quality, and strength, has become a common hallmark of ageing and many chronic diseases. Diabetes mellitus patients have a higher prevalence of sarcopenia, which greatly aggravates the metabolic disturbance and compromises treatment response. Preclinical and clinical studies have shown differential impacts of anti‐diabetic drugs on skeletal muscle mass, strength, and performance, highlighting the importance of rational therapeutic regimen from the perspective of sarcopenia risk. In this review, we provide an update on the regulation of muscle mass and quality by major anti‐diabetic drugs, focusing primarily on emerging data from clinical studies. We also discuss the underlying mechanisms and clinical implications for optimal selection of anti‐diabetic drugs to reduce the risk of sarcopenia. In view of the lifelong use of anti‐diabetic drugs, we propose that a better understanding of the sarcopenia risk and interventional strategies is worthy of attention in future studies.

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Section: Prevalence and Pathophysiological Characteristics Of Sarcopenia In Diabetic Patientsmentioning

confidence: 95%

Anti‐diabetic drugs and sarcopenia: emerging links, mechanistic insights, and clinical implications

Zhang

Zhao

Chen

et al. 2021

J cachexia sarcopenia muscle

View full text Add to dashboard Cite

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Impacts of elevated glycaemic haemoglobin and disease duration on the sensorimotor control of hands in diabetes patients

Hsu

Chiu

Lin

et al. 2015

Diabetes Metabolism Res

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Neuromuscular dysfunction in type 2 diabetes: underlying mechanisms and effect of resistance training

Orlando

Balducci

Bazzucchi

et al. 2015

Diabetes Metabolism Res

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Diabetic patients are at higher risk of developing physical disabilities than non-diabetic subjects. Physical disability appears to be related, at least in part, to muscle dysfunction. Several studies have reported reduced muscle strength and power under dynamic and static conditions in both the upper and lower limbs of patients with type 2 diabetes. Additional effects of diabetes include a reduction in muscle mass, quality, endurance and an alteration in muscle fibre composition, though the available data on these parameters are conflicting. The impact of diabetes on neuromuscular function has been related to the co-existence of long-term complications. Peripheral neuropathy has been shown to affect muscle by impairing motor nerve conduction. Also, vascular complications may contribute to the decline in muscle strength. However, muscle dysfunction occurs early in the course of diabetes and affects also the upper limbs, thus suggesting that it may develop independently of micro and macrovascular disease. A growing body of evidence indicates that hyperglycaemia may cause an alteration of the intrinsic properties of the muscle to generate force, via several mechanisms. Recently, resistance exercise has been shown to be an effective strategy to counteract the deterioration of muscular performance. High-intensity exercise seems to provide greater benefits than moderate-intensity training, whereas the effect of a power training is yet unknown. This article reviews the available literature on the impairment of muscle function induced by diabetes, the underlying mechanisms, and the effect of resistance training on this defect. Copyright © 2015 John Wiley & Sons, Ltd.

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Are we ignoring diabetic disability: A cross sectional study of diabetic myopathy

Cited by 10 publications

References 17 publications

Anti‐diabetic drugs and sarcopenia: emerging links, mechanistic insights, and clinical implications

Anti‐diabetic drugs and sarcopenia: emerging links, mechanistic insights, and clinical implications

Impacts of elevated glycaemic haemoglobin and disease duration on the sensorimotor control of hands in diabetes patients

Neuromuscular dysfunction in type 2 diabetes: underlying mechanisms and effect of resistance training

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