Are upper gastrointestinal symptoms associated with exacerbations of COPD?

Cholongitas, Evangelos; Pipili, Chrysoula; Dasenaki, Maria; Goudras, S.

doi:10.1111/j.1742-1241.2008.01772.x

Cited by 11 publications

(7 citation statements)

References 8 publications

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“…These results indicate that greater severity of GERD symptoms may lead to more frequent AECOPD, consistent with other investigations. 5,8,21 In addition, FSSG subscores showed similar associations to those of the total score, which may suggest that GERD in COPD patients is caused by both acid reflux and gastric dysmotility.…”

Section: Discussionmentioning

confidence: 80%

Prospective evaluation of the relationship between acute exacerbations of COPD and gastroesophageal reflux disease diagnosed by questionnaire

Takada

Matsumoto

Kojima

et al. 2011

Respiratory Medicine

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Section: Discussionmentioning

confidence: 80%

Prospective evaluation of the relationship between acute exacerbations of COPD and gastroesophageal reflux disease diagnosed by questionnaire

Takada

Matsumoto

Kojima

et al. 2011

Respiratory Medicine

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“…Alternatively, it has been suggested by a number of investigators ( 26 , 28 , 34 , 47 , 54 , 55 ) that the association between GER and a wide range of respiratory diseases is best explained by the diseases causing or contributing to GER. There are various plausible hypotheses supporting this explanation.…”

Section: Discussionmentioning

confidence: 99%

Exacerbations of COPD and symptoms of gastroesophageal reflux: a systematic review and meta-analysis

et al. 2013

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OBJECTIVE: To examine the relationship between gastroesophageal reflux (GER) and COPD exacerbations. METHODS: We conducted a systematic search of various electronic databases for articles published up through December of 2012. Studies considered eligible for inclusion were those dealing with COPD, COPD exacerbations, and GER; comparing at least two groups (COPD vs. controls or GER vs. controls); and describing relative risks (RRs) and prevalence ratios-or ORs and their respective 95% CIs (or presenting enough data to allow further calculations) for the association between GER and COPD-as well as exacerbation rates. Using a standardized form, we extracted data related to the study design; criteria for GER diagnosis; age, gender, and number of participants; randomization method; severity scores; methods of evaluating GER symptoms; criteria for defining exacerbations; exacerbation rates (hospitalizations, ER visits, unscheduled clinic visits, prednisone use, and antibiotic use); GER symptoms in COPD group vs. controls; mean number of COPD exacerbations (with symptoms vs. without symptoms); annual frequency of exacerbations; GER treatment; and severity of airflow obstruction. RESULTS: Overall, GER was clearly identified as a risk factor for COPD exacerbations (RR = 7.57; 95% CI: 3.84-14.94), with an increased mean number of exacerbations per year (mean difference: 0.79; 95% CI: 0.22-1.36). The prevalence of GER was significantly higher in patients with COPD than in those without (RR = 13.06; 95% CI: 3.64-46.87; p < 0.001). CONCLUSIONS: GER is a risk factor for COPD exacerbations. The role of GER in COPD management should be studied in greater detail.

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“…It is possible that emphysematous change and hyperinflation of the lung could enlarge total lung capacity, flatten the diaphragm, and increase the risk of sliding hernia of the esophagus [Clemencon and Osterman, 1961]. Although GERD does not appear to predispose patients to the development of COPD de novo, it is possible that GERD may worsen pre-existing COPD by, for example, increasing the frequency of exacerbations [Cholongitas et al 2008;Rascon-Aguilar et al 2006]. Improvements in respiratory symptoms have been observed in patients receiving acidsuppressive therapy for GERD [Hungin et al 2005].…”

Section: ] Effects On Inflammatory Cellsmentioning

confidence: 99%

A new strategy with proton pump inhibitors for the prevention of acute exacerbations in COPD

Sasaki

Nakayama

Yasuda

et al. 2011

Therapeutic Advances in Respiratory

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Acute exacerbations of chronic obstructive pulmonary disease (COPD), an acute worsening of respiratory symptoms, generally result in a poor prognosis. Successful prevention and management of such exacerbations is thus important for patient care. Viral infection, primarily with rhinovirus (RV), is the foremost cause of exacerbations in COPD patients. Proton pump inhibitors (PPIs) have been reported to inhibit RV infection in human airway epithelial cells in vitro. Furthermore, clinical trials of PPIs in patients with COPD resulted in a reduction in rates of both common cold and COPD exacerbations. In this review, we discuss the significance of COPD exacerbations, summarize a published trial of the effect of low-dose PPIs on COPD exacerbations, and postulate a mechanism for this effect.

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Are upper gastrointestinal symptoms associated with exacerbations of COPD?

Cited by 11 publications

References 8 publications

Prospective evaluation of the relationship between acute exacerbations of COPD and gastroesophageal reflux disease diagnosed by questionnaire

Prospective evaluation of the relationship between acute exacerbations of COPD and gastroesophageal reflux disease diagnosed by questionnaire

Exacerbations of COPD and symptoms of gastroesophageal reflux: a systematic review and meta-analysis

A new strategy with proton pump inhibitors for the prevention of acute exacerbations in COPD

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