We consider the classical problem of selling a single item to a single bidder whose value for the item is drawn from a regular distribution F , in a "data-poor" regime where F is not known to the seller, and very few samples from F are available. Prior work [9] has shown that one sample from F can be used to attain a 1/2-factor approximation to the optimal revenue, but it has been challenging to improve this guarantee when more samples from F are provided, even when two samples from F are provided. In this case, the best approximation known to date is 0.509, achieved by the Empirical Revenue Maximizing (ERM) mechanism [2]. We improve this guarantee to 0.558, and provide a lower bound of 0.65. Our results are based on a general framework, based on factor-revealing Semidefinite Programming relaxations aiming to capture as tight as possible a superset of product measures of regular distributions, the challenge being that neither regularity constraints nor product measures are convex constraints. The framework is general and can be applied in more abstract settings to evaluate the performance of a policy chosen using independent samples from a distribution and applied on a fresh sample from that same distribution. CCS Concepts: • Theory of computation → Algorithmic game theory and mechanism design; Algorithmic mechanism design.