Are there gender differences in patients presenting with unstable angina?

Chua, Tuan Peng; Saia, Francesco; Bhardwaj, Vandana; Wright, Christine; Clarke, Debbie; Hennessy, Martina; K, Fox

doi:10.1016/s0167-5273(99)00204-1

Cited by 16 publications

(4 citation statements)

References 22 publications

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“…Consistent with prior studies and clinical experience, our results indicate that women and men who present with ACS are a heterogeneous group. Studies of low-risk patients have consistently found either no significant difference in the mortality rate between women and men or a lower rate among women4, 5, 12, 41. In contrast, studies of women at higher risk note similar or increased risk compared with men6, 9, 16.…”

Section: Discussionmentioning

confidence: 99%

Sex Differences in Mortality Following Acute Coronary Syndromes

Berger¹

2009

JAMA

459

290

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ARDIOVASCULAR DISEASE IS THE leading cause of death in both men and women, accounting for one-third of all deaths. 1 Although several studies have shown an improvement of prognosis in women over time, 2 overall outcomes remain worse for women compared with men, 3 providing a strong rationale for focusing on the study of sex-based differences in the outcome of acute coronary syndromes (ACS). Previous analyses of sex-based differences following ACS have reported conflicting results, even after adjustment for demographics and clinical characteristics. [4][5][6][7][8][9][10][11][12][13][14][15][16][17] In a large systematic review comparing short-term mortality between women and men, Vaccarino et al 3 concluded that after adjustment for differences in age and baseline prognostic factors, some but not all of the excess mortality was explained.Several studies have offered novel approaches to understanding sexbased differences following ACS. 14,[18][19][20][21] A large cohort analysis from the National Registry of Myocardial Infarction demonstrated a higher risk of early death for younger but not older women. 14 A prior analysis from the Global Use of Strategies to Open Occluded Arteries in Acute Coronary Syndromes (GUSTO IIb) 22 found that women and men have outcomes that differ according to the type of ACS.

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Section: Discussionmentioning

confidence: 99%

Sex Differences in Mortality Following Acute Coronary Syndromes

Berger¹

2009

JAMA

459

290

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“…There have been few studies 6,10,19,20 examining sex disparities in UA, and all have been based on patients enrolled in clinical trials. These studies reported shortterm (infarct-free) survival that was similar or better among women compared with men.…”

mentioning

confidence: 99%

Impact of Sex on Long-term Mortality From Acute Myocardial Infarction vs Unstable Angina

Chang¹,

Kaul²,

Westerhout³

et al. 2003

Arch Intern Med

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“…Moreover, using high sensitivity troponin as a single diagnostic marker I proved that it is not efficient in MI diagnosis in women and contribute to sex inequalities in treatments and outcomes. This sex difference has been observed in other studies may be due to differences in presentation, with women more likely to have atypical symptoms and less reliable electrocardiographic changes (Chua et al, 2000). However, others4 have found that the same proportion of men and women reported chest pain and had electrocardiographic changes.…”

Section: Results and Disucssonmentioning

confidence: 66%

Use of Copeptin in Differential Diagnosis of (Acs) for Males vs Females in Emergency Departmen

Shahin

Maksoud

et al. 2016

Research Journal of Applied Biotechnology

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Difference between men and women in the treatment and outcome of acute coronary syndromes has been demonstrated with increased deaths rates in women. Treatment of ACS must be revised and related to the sex and race of the patient. The aim of this study was to introduce new copeptin cutoff levels in ACS patients depending of gender. Also, to compare copeptin to hs-cTnI, CRP levels to predict time delayed between ACS symptoms onset and admission to ED. Sixty two consecutive patients with ACS presenting to the emergency department of the National Heart Institute, Giza (Egypt) between March and June 2014, were recruited for the study. The present study involved thirty patients with unstable angina (19 male & 11 females), thirty two MI patients (18 males & 14 females) and twenty healthy subjects (10 males &10 females) on admission and after 6 hours. Results revealed significant difference between cardiac levels on admission with higher values in men on admission only for CPP, disappeared after six hours. Only copeptin levels were diagnosing on admission (higher with clear cut off levels either for men or women) compared to that of six hours (decreased and get non-significant differences). Early measurement of the combination of troponin I and copeptin may revolutionize the diagnostic accuracy and therapeutic decision-making in patients with symptoms suggestive of ACS, differentiate between UA or AMI patients on admission. Female patients require reevaluation criteria for treatment and outcome.

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Are there gender differences in patients presenting with unstable angina?

Cited by 16 publications

References 22 publications

Sex Differences in Mortality Following Acute Coronary Syndromes

Sex Differences in Mortality Following Acute Coronary Syndromes

Impact of Sex on Long-term Mortality From Acute Myocardial Infarction vs Unstable Angina

Use of Copeptin in Differential Diagnosis of (Acs) for Males vs Females in Emergency Departmen

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