Are There Dissociable Roles of the Mesostriatal and Mesolimbocortical Dopamine Systems on Temporal Information Processing in Humans?

Rammsayer, Thomas

doi:10.1159/000119328

Cited by 113 publications

(86 citation statements)

References 48 publications

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“…The SMA is important in self-initiated or "willed" actions (Jahanshahi et al, 1995); and increased SMA activation could reflect demands on conscious temporal processing and response initiation strategies in seconds-range timing. Right DLPFC activation during seconds-range timing may indicate engagement of working memory processes (Rammsayer, 1997(Rammsayer, , 1999, consistent with previous research in which repetitive transcranial magnetic stimulation over right DLPFC disrupted time reproduction in the seconds-range only (Jones et al, 2004). For the LONG Ͼ SHORT contrast, the right hemisphere was predominately activated, which reflects previous findings of right hemisphere dominance in temporal processing (Harrington et al, 1998b;Rao et al, 2001;Macar et al, 2002;Lewis and Miall, 2006).…”

Section: Cortical Activationsupporting

confidence: 84%

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The Substantia Nigra Pars Compacta and Temporal Processing

Jahanshahi¹,

Jones²,

Dirnberger³

et al. 2006

J. Neurosci.

130

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The basal ganglia and cerebellum are considered to play a role in timing, although their differential roles in timing remain unclear. It has been proposed that the timing of short milliseconds-range intervals involves the cerebellum, whereas longer seconds-range intervals engage the basal ganglia (Ivry, 1996). We tested this hypothesis using positron emission tomography to measure regional cerebral blood flow in eight right-handed males during estimation and reproduction of long and short intervals. Subjects performed three tasks: (1) reproduction of a short 500 ms interval, (2) reproduction of a long 2 s interval, and (3) a control simple reaction time (RT) task. We compared the two time reproduction tasks with the control RT task to investigate activity associated with temporal processing once additional cognitive, motor, or sensory processing was controlled. We found foci in the left substantia nigra and the left lateral premotor cortex to be significantly more activated in the time reproduction tasks than the control RT task. The left caudate nucleus and right cerebellum were more active in the short relative to the long interval, whereas greater activation of the right putamen and right cerebellum occurred in the long rather than the short interval. These results suggest that the basal ganglia and the cerebellum are engaged by reproduction of both long and short intervals but play different roles. The fundamental role of the substantia nigra in temporal processing is discussed in relation to previous animal lesion studies and evidence for the modulating influence of dopamine on temporal processing.

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Section: Cortical Activationsupporting

confidence: 84%

“…Whereas dopamine within the basal ganglia affects millisecond-and seconds-range timing, mesolimbocortical dopamine only affects seconds-range timing (Rammsayer, 1993(Rammsayer, , 1997. The differential patterns of cortical activation may relate to the way subjects timed the intervals.…”

Section: Cortical Activationmentioning

confidence: 99%

The Substantia Nigra Pars Compacta and Temporal Processing

Jahanshahi¹,

Jones²,

Dirnberger³

et al. 2006

J. Neurosci.

130

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“…Our results may be seen as having parallels with Rammsayer's (1992Rammsayer's ( , 1993Rammsayer's ( , 1997Rammsayer's ( , 1999Rammsayer's ( , 2006 findings that the timing of longer intervals is more susceptible to drug effects than the timing of shorter intervals. The relative insensitivity of short interval timing to the disruptive effects of drugs has been taken as evidence against a unitary account of timing based on a single timer.…”

Section: Discussionsupporting

confidence: 85%

“…Thus, for example, the sedative gas nitrous oxide alters time estimation and production in a manner consistent with a decrease in the internal timer rate (Adam et al 1974); alcohol has been shown to predispose the overproduction of time intervals (e.g., Tinklenberg et al 1972Tinklenberg et al , 1976, and secobarbital promotes the underestimation of stimulus durations (Goldstone et al 1958;Goldstone and Kirkham 1968). Furthermore, the accuracy of temporal discrimination is impaired by the neuroleptic haloperidol across a range of time intervals (Rammsayer 1989(Rammsayer , 1993(Rammsayer , 1997(Rammsayer , 1999. In contrast, the psychostimulant drug dextroamphetamine causes overestimation of stimulus durations (Goldstone et al 1958;Goldstone and Kirkham 1968), and caffeine has been shown to improve the estimation accuracy of durations in the range of seconds (at least at one particular dose in females; Botella et al 2001).…”

Section: Introductionmentioning

confidence: 99%

“…Many drug effects on timing are specific to certain time intervals: for example, the minor tranquillizer midazolam, the atypical neuroleptic remoxipride, and the NMDA receptor antagonist memantine, all reduce estimation accuracy for longer time intervals (in the range of seconds) but not for shorter intervals (in the range of hundreds of milliseconds; Rammsayer 1992Rammsayer , 1993Rammsayer , 1997Rammsayer , 1999Rammsayer , 2006, and the noradrenaline reuptake inhibitor reboxetine improves accuracy only at longer intervals (Rammsayer et al 2001). These dissociations, together with recent neuroimaging evidence (for a review see Lewis and Miall 2003) suggest that intervals below and above approximately one second are represented by two distinct timing processes that may be differentially sensitive to drug effects.…”

Section: Introductionmentioning

confidence: 99%

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Dissociations between motor timing, motor coordination, and time perception after the administration of alcohol or caffeine

et al. 2008

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Rationale The impacts of psychoactive drugs on timing have usefully informed theories of timing and its substrates. Objectives The objectives of the study are to test the effects of alcohol and caffeine on the explicit timing involved in tapping with the implicit timing observed in the coordinated picking up of an object, and with the temporal discrimination. Materials and methods Participants in the "alcohol" experiment (N=16) received placebo, "low" (0.12 g/kg or 0.14 g/kg for women/men, respectively) or "high" (0.37 g/kg or 0.42 g/kg, respectively) doses of alcohol, and those in the "caffeine" experiment (N=16) received placebo, 200 or 400 mg caffeine. Time production variability was measured by repetitive tapping of specified intervals, and sources of variance attributable to central timer processes and peripheral motor implementation were dissociated. The explicit timing in tapping was compared with the implicit timing in the coordinated picking up of an object. Time perception was measured as discrimination thresholds for intervals of similar duration. Drug effects on reaction time were also measured. Results For tapping, alcohol significantly increased timer variability, but not motor variability; it did not affect coordination timing in the grip-lift task. Conversely, for time perception, the low dose of alcohol improved temporal discrimination. Caffeine produced no effects on any of the timing tasks, despite significantly reducing reaction times. Conclusions The effects of alcohol argue against a common clock process underlying time interval perception and production in the range below 1 s. In contrast to reaction time measures, time perception and time production appear relatively insensitive to caffeine.

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Timing and Time Perception

Kononowicz

Rijn

Meck

2018

Stevens' Handbook of Experimental Psychology and Cognitive Neuroscience

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This chapter reviews recent human and nonhuman animal studies investigating neural signatures of time estimation. Investigation of the neural correlates of time estimation as measured by electrophysiology, electroencephalography, magnetoencephalography, and functional magnetic resonance imaging (fMRI) in humans and other animals has largely been focused on the to‐be‐timed period. Climbing neural activity (e.g., ramping) originating from the supplementary motor area has been implicated as a primary neural marker that coincides with the development of subjective experience of duration. However, it has recently been questioned whether such climbing neural activity directly reflects the neural mechanism(s) underpinning the sense of time. Given that the neural signatures recorded during the to‐be‐timed period are insufficient to explain various aspects of interval timing, this has led to the consideration of processes influencing timing before and after the to‐be‐timed period. Because many of these signatures are linked with the supplementary motor area, an extended discussion of the role of this cortical structure in timing and time perception is provided. These neural correlates are interpreted in light of contemporary theories of interval timing, such as the striatal beat frequency model. Future directions for the investigation of the functional and neural mechanisms of interval timing are also discussed.

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Are There Dissociable Roles of the Mesostriatal and Mesolimbocortical Dopamine Systems on Temporal Information Processing in Humans?

Cited by 113 publications

References 48 publications

The Substantia Nigra Pars Compacta and Temporal Processing

The Substantia Nigra Pars Compacta and Temporal Processing

Dissociations between motor timing, motor coordination, and time perception after the administration of alcohol or caffeine

Timing and Time Perception

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