Are There Differences in the Anthropometric, Hemodynamic, Hematologic, and Biochemical Profiles between Late- and Early-Onset Preeclampsia?

Abstract

Preeclampsia (PE) is classified as early-onset PE (EOPE) and late-onset PE (LOPE) when present before or after 34 weeks of gestation, respectively. This transversal study aimed to investigate the differences and possible associations existing in the anthropometric, hemodynamic, hematologic, and biochemical profiles of late- and early-onset preeclampsia. The study included 65 volunteers admitted to a tertiary hospital in Brazil: 29 normotensive and 36 with preeclampsia (13 with EOPE and 23 with LOPE). Pregnant women with LOPE presented greater weight gain and borderline increase in body mass index at the end of gestation in relation to the other groups, which is compatible with the metabolic origin, associated with obesity, attributed to this form of the disease. Pregnant women with EOPE presented a borderline reduction in the number of erythrocytes and a significant decrease in the number of platelets, in addition to a significant increase in reticulocytes, serum iron, and ferritin when compared to normotensive pregnant women and pregnant women with LOPE. A significant increase in osmotic stability of erythrocytes was observed in the EOPE group in relation to other groups. Hemodynamic analysis by Doppler ultrasonography of the ophthalmic artery showed that both groups of pregnant women with PE presented alterations compatible with the occurrence of hyperflow in the orbital territory. These hemodynamic changes were associated with changes in hematimetric indices.

Reply

“…on carotid artery Doppler, the diastolic phase of a cardiac cycle starts shortly after the dicrotic notch of the carotid artery Doppler waveform. The location of the second systolic peak was also shown correctly in recent work by Dr Debs Diniz's group. Accordingly, the correct version of the supplementary figure 2 is presented here (Figure ).…”

The role of the erythrocyte in the outcome of pregnancy with preeclampsia

“…Therefore, the findings obtained by the ophthalmic artery dopplervelocimetric analysis can be extrapolated to the cerebral circulation [7]. Since 1995, several authors have described the pattern of hyperflow in orbital territory in patients with pre-eclampsia by Doppler velocimetry of the ophthalmic artery [8–11].…”

“…Although the evaluation of osmotic stability of the erythrocyte membrane is well established in the literature [23,24], the number of studies on osmotic stability of erythrocyte membrane in preeclampsia is still quite small [11,21,25].…”

The influence of a hot environment on physiological stress responses in exercise until exhaustion

“…Blood samples were transferred to mini tubes containing 50 μl of 1% sodium fluoride and stored at -20°C for analysis of lactate. The Lactate measurements were completed in duplicate by an electro-enzymatic method in an automated analyzer (YSI 2300 Sport L-lactate analyzer, USI Inc, Yellow Spring, Ohio, USA) [28].…”