Are there clinical differences between familial and nonfamilial Alzheimer's disease?

We attempted to determine the relationship between psychiatric symptoms and psychotropic drug use in persons with Alzheimer's disease based on a multicenter patient registry of 671 community‐living persons diagnosed with the disease by published criteria. Logistic regression was performed to determine which symptoms were associated psychotropic use after controlling for age, sex, and Mini‐Mental Status Examination (MMSE) score. At least one psychotropic drug was reported by 31% of patients, and 66% had at least one psychiatric symptom. Antipsychotics were associated with a lower MMSE score (odds ratio=0.92, 95% confidence interval 0.88‐0.97), emotional lability (OR=4.52, 95% CI 1.69‐11.94), and hallucinations (OR=6.54, 95% CI 2.99‐14.26). Antidepressants were associated with depressive symptoms (OR=5.8, 95% CI 2.61‐13.46), and benzodiazepines with a lower MMSE score (OR=0.93, 95% CI 0.90‐0.97). Community‐living persons with Alzheimer's disease are frequently prescribed psychotropic drugs; however, more than 50% of patients with a psychiatric symptom did not report taking one of these agents. This suggests that alternative therapies and no treatment are also prevalent.

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The management of other psychiatric states: Hallucinations, Delusions, and Other Disturbances

Loebel¹,

Leibovici²

1994

Medical Clinics of North America

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Are there clinical differences between familial and nonfamilial Alzheimer's disease?

Abstract: The association of faster course and family history of psychiatric disorders in the patients with a family history of dementia is consistent with the hypothesis of heterogeneity, but the overall results could also be explained by a genetic-environmental model of Alzheimer's disease.

Cited by 12 publications

References 31 publications

Patterns of Risk in First-Degree Relatives of Patients With Alzheimer's Disease

Patterns of Risk in First-Degree Relatives of Patients With Alzheimer's Disease

Psychotropic Drug Use in Relation to Psychiatric Symptoms in Community‐Living Persons With Alzheimer's Disease

The management of other psychiatric states: Hallucinations, Delusions, and Other Disturbances

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