Are There Circadian Clocks in Non-Photosynthetic Bacteria?

Sartor, Francesca; Eelderink-Chen, Zheng; Aronson, Ben; Bosman, Jasper; Hibbert, Lauren E.; Dodd, Antony N.; Kovács, Ákos T.; Merrow, Martha

doi:10.3390/biology8020041

Cited by 33 publications

(31 citation statements)

References 112 publications

(135 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The monocellular (unicellular) eukaryotes and prokaryotes comprise of major disease agents to the metazoa, but their chronobiology has remained rudimentary, mainly due to our understanding that most bacteria are not photoreceptive (the notable exceptions being the cyanobacteria and the purple bacteria). Indirect evidence of CC in non-photosynthetic bacteria has been reported sporadically in several well-known species such as Escherichia coli , Klebsiella sp., Pseudomonas putida , and Bacillus subtilis , based on growth measurements, swarming response, and reporter gene expression in laboratory assays [48,49]. Genome survey of all prokaryotes found homologs of the cyanobacterial circadian gene KaiC in several other bacteria, including the nitrogen-fixing rhizobacteria and P. putida [48].…”

Section: Interactions Between the Circadian Clock And Microbial Inmentioning

confidence: 99%

Molecular Interactions between Pathogens and the Circadian Clock

Barik

2019

IJMS

View full text Add to dashboard Cite

The daily periodicity of the Earth’s rotation around the Sun, referred to as circadian (Latin “circa” = about, and “diem” = day), is also mirrored in the behavior and metabolism of living beings. The discovery that dedicated cellular genes control various aspects of this periodicity has led to studies of the molecular mechanism of the circadian response at the cellular level. It is now established that the circadian genes impact on a large network of hormonal, metabolic, and immunological pathways, affecting multiple aspects of biology. Recent studies have extended the role of the circadian system to the regulation of infection, host–pathogen interaction, and the resultant disease outcome. This critical review summarizes our current knowledge of circadian-pathogen interaction at both systemic and cellular levels, but with emphasis on the molecular aspects of the regulation. Wherever applicable, the potential of a direct interaction between circadian factors and pathogenic macromolecules is also explored. Finally, this review offers new directions and guidelines for future research in this area, which should facilitate progress.

show abstract

Section: Interactions Between the Circadian Clock And Microbial Inmentioning

confidence: 99%

Molecular Interactions between Pathogens and the Circadian Clock

Barik

2019

IJMS

View full text Add to dashboard Cite

show abstract

“…how it regulates processes essential for bacteria survival and adaptation to environmental changes is still an open question (Sartor et al, 2019).…”

Section: Circadian Rhythm In Non-photosynthetic Bacteriamentioning

confidence: 99%

“…However, these rhythms were not temperature compensated, therefore not classically definable circadian. More recently, a circadian oscillation was reported in the growth of the soil bacteria Pseudomonas putida (Soriano et al, 2010), as well as in Bacillus subtilis (Sartor et al, 2019), a famous gram-positive bacterium, important for its various industrial and medical applications. This bacterium in particular displays a 24-h oscillation in gene expression associated with growth, differentiation and spore formation, and it has been pointed out as a potential model organism for further circadian studies in non-photosynthetic bacteria.…”

Section: Circadian Rhythm In Non-photosynthetic Bacteriamentioning

confidence: 99%

Microbes in the Era of Circadian Medicine

Costantini

Renga

Sellitto

et al. 2020

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

The organisms of most domains of life have adapted to circadian changes of the environment and regulate their behavior and physiology accordingly. A particular case of such paradigm is represented by some types of host-pathogen interaction during infection. Indeed, not only some hosts and pathogens are each endowed with their own circadian clock, but they are also influenced by the circadian changes of the other with profound consequences on the outcome of the infection. It comes that daily fluctuations in the availability of resources and the nature of the immune response, coupled with circadian changes of the pathogen, may influence microbial virulence, level of colonization and damage to the host, and alter the equilibrium between commensal and invading microorganisms. In the present review, we discuss the potential relevance of circadian rhythms in human bacterial and fungal pathogens, and the consequences of circadian changes of the host immune system and microbiome on the onset and development of infection. By looking from the perspective of the interplay between host and microbes circadian rhythms, these concepts are expected to change the way we approach human infections, not only by predicting the outcome of the host-pathogen interaction, but also by indicating the best time for intervention to potentiate the anti-microbial activities of the immune system and to weaken the pathogen when its susceptibility is higher.

show abstract

“…Probably due to the efficient adaptation to the cycle of environmental changes generated by the Earth's 24-h rotation, living organisms internalize a cell-autonomous clock, the so-called circadian clock. From bacteria to humans, most living beings possess a circadian clock in the body [1,2], and this characteristic of organisms persisted even across explosive evolution and mass extinction events, suggesting that circadian clock systems were internalized in living beings from early in their evolution rather than acquired later as a trait.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA: A Key Player for the Interplay of Circadian Rhythm Abnormalities, Sleep Disorders and Neurodegenerative Diseases

et al. 2020

View full text Add to dashboard Cite

Circadian rhythms are endogenous 24-h oscillators that regulate the sleep/wake cycles and the timing of biological systems to optimize physiology and behavior for the environmental day/night cycles. The systems are basically generated by transcription–translation feedback loops combined with post-transcriptional and post-translational modification. Recently, evidence is emerging that additional non-coding RNA-based mechanisms are also required to maintain proper clock function. MicroRNA is an especially important factor that plays critical roles in regulating circadian rhythm as well as many other physiological functions. Circadian misalignment not only disturbs the sleep/wake cycle and rhythmic physiological activity but also contributes to the development of various diseases, such as sleep disorders and neurodegenerative diseases. The patient with neurodegenerative diseases often experiences profound disruptions in their circadian rhythms and/or sleep/wake cycles. In addition, a growing body of recent evidence implicates sleep disorders as an early symptom of neurodegenerative diseases, and also suggests that abnormalities in the circadian system lead to the onset and expression of neurodegenerative diseases. The genetic mutations which cause the pathogenesis of familial neurodegenerative diseases have been well studied; however, with the exception of Huntington’s disease, the majority of neurodegenerative diseases are sporadic. Interestingly, the dysfunction of microRNA is increasingly recognized as a cause of sporadic neurodegenerative diseases through the deregulated genes related to the pathogenesis of neurodegenerative disease, some of which are the causative genes of familial neurodegenerative diseases. Here we review the interplay of circadian rhythm disruption, sleep disorders and neurodegenerative disease, and its relation to microRNA, a key regulator of cellular processes.

show abstract

Are There Circadian Clocks in Non-Photosynthetic Bacteria?

Cited by 33 publications

References 112 publications

Molecular Interactions between Pathogens and the Circadian Clock

Molecular Interactions between Pathogens and the Circadian Clock

Microbes in the Era of Circadian Medicine

MicroRNA: A Key Player for the Interplay of Circadian Rhythm Abnormalities, Sleep Disorders and Neurodegenerative Diseases

Contact Info

Product

Resources

About