Are There Changes in Gastric Emptying during the Menstrual Cycle?

Caballero-Plasencia, Antonio M.; Valenzuela-Barranco, Manuel; Martin-Ruiz, J. L.; Herrerías‐Gutiérrez, Juan Manuel; Esteban-Carretero, José M.

doi:10.1080/003655299750025697

Cited by 51 publications

(21 citation statements)

References 21 publications

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“…This finding may be of particular relevance to the current report of increased microparticle uptake during pregnancy, although the upward trend in uptake in the virgin female groups cannot yet be linked to hormonal differences, since the role of progesterone in gastrointestinal motility is still not clear (Caballero-Plasencia et al, 1999;Oh et al, 1998).…”

Section: Discussionmentioning

confidence: 49%

“…Motility disorders occur more often in women than in men (Ducker et al, 1996). Gastric emptying of digestive solids and liquids is slower in women than men (Caballero-Plasencia et al, 1999) but there is no link with the cyclical changes in plasma levels of sex hormones. Late pregnancy slows intestinal transit in rats, but does not alter gastric emptying (Chang et al, 1998) while the early lactation period is accompanied by an increase in both (Chen et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

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Effect of reproductive status on uptake of latex microparticles in rat small intestine

et al. 2005

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Section: Discussionmentioning

confidence: 49%

Section: Introductionmentioning

confidence: 99%

Effect of reproductive status on uptake of latex microparticles in rat small intestine

et al. 2005

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“…Other research suggests that while gastric emptying does appear to be more delayed in women than in men, this is not accounted for by the phases of the menstrual cycle or plasma concentrations of oestradiol or progesterone. [22][23][24] A systematic review has examined the relationship between HRQOL and functional dyspepsia. 15 It was concluded that the evidence that HRQOL is substantially affected by functional dyspepsia was remarkably limited despite the high prevalence and enormous cost of this condition.…”

Section: Discussionmentioning

confidence: 99%

Functional dyspepsia, delayed gastric emptying, and impaired quality of life

Talley

2006

Gut

245

166

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Background: It remains controversial as to whether delayed gastric emptying in functional dyspepsia is associated with a specific symptom pattern, and it is unknown if gastric emptying in functional dyspepsia is a driver of impaired health related quality of life (HRQOL). We aimed to evaluate the relationship between functional dyspepsia symptoms, gastric emptying, and HRQOL. Methods: US patients (n = 864; mean age 44 years (range 18-82); 74% female) with functional dyspepsia, as defined by Rome II criteria, were enrolled into one of four clinical trials. All patients had a baseline scintigraphic assessment of gastric emptying of an egg substitute meal, and the trials were stratified on this assessment. Delayed gastric emptying was defined as having at least 6.3% residual volume at four hours. A total of 290 (34%) patients had delayed gastric emptying. HRQOL was assessed by the SF 36 and Nepean dyspepsia index (NDI). Results: Postprandial fullness was independently associated with delayed gastric emptying but the association was weak (odds ratio (OR) 1.98 (95% confidence interval (CI) 1.02, 3.86); p = 0.04). No independent association was seen with epigastric pain, early satiety, nausea, or bloating. Mean SF 36 physical composite score (PCS) was 42.3 (95% CI 41.6, 43.0) and the mean SF 36 mental composite score (MCS) was 46.8 (95% CI 46.0, 47.5); both mean scores were significantly lower than age and sex adjusted national norms of 50 (p,.0001). Female sex, increasing age, and higher symptom scores for fullness, epigastric pain, and nausea were each independently associated with decreased PCS scores (all p,0.05). Higher baseline nausea symptom score, lower gastric emptying rates at one hour, and lower body mass index were associated with decreased MCS (all p,0.05). Female sex, epigastric pain, and nausea, but not gastric emptying, were associated with an impaired score on the NDI. However, the magnitude of the significant associations were all small. Conclusions: In patients with functional dyspepsia selected for a clinical trial programme, gastric emptying did not usefully stratify them symptomatically. Quality of life of patients with functional dyspepsia enrolled in this clinical trial programme was significantly impaired but this was not explained by delayed gastric emptying.

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“…Such complaints may not be explained by quantifiable physiologic changes in gastric function, which complicates their treatment by Western medicine. [15][16][17][18] An example of culture-specific symptoms is the feeling of coldness (hie). In our cases, hie was among the complaints of patient 3.…”

Section: Gepshtein Et Al 432mentioning

confidence: 99%

Kampo in Women's Health: Japan's Traditional Approach to Premenstrual Symptoms

Gepshtein

Plotnikoff

Watanabe

2008

The Journal of Alternative and Complementary Medicine

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Kampo is Japan's traditional herbal medicine and it is an integral part of the official Westernized medical system in Japan. We describe the Kampo approach to premenstrual symptoms. We present 3 clinical cases of women treated for premenstrual discomforts in a Kampo clinic in Japan. Each of these women reported improvement in their conditions. We argue that Kampo is well-suited for treatment of premenstrual symptoms in Japan and deserves the attention of Western clinicians for three reasons: (1) patient-centered Kampo diagnosis allows physicians to handle subjective and culture-bound symptoms that are often ignored by Western medicine; (2) Kampo herbal formulas are regulated by the Japanese government, and are pure and of high quality; and (3) the settings in which Kampo is practiced set a stage for therapeutic collaboration between the doctor and the patient.

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Are There Changes in Gastric Emptying during the Menstrual Cycle?

Abstract: Evidence of postprandial 'physiologic gastroparesis' was found in women, although no differences were found between men and women in gastric motility during fasting. The rate of emptying was not related to changes in plasma concentrations of sex hormones during the menstrual cycle.

Cited by 51 publications

References 21 publications

Effect of reproductive status on uptake of latex microparticles in rat small intestine

Effect of reproductive status on uptake of latex microparticles in rat small intestine

Functional dyspepsia, delayed gastric emptying, and impaired quality of life

Kampo in Women's Health: Japan's Traditional Approach to Premenstrual Symptoms

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