Are There Any Significant Differences Between Females and Males in the Management of Heart Failure? Gender Aspects of an Elderly Population With Symptoms Associated With Heart Failure

Alehagen, Urban; Ericsson, Anne; Dahlström, Ulf

doi:10.1016/j.cardfail.2009.01.010

Cited by 19 publications

(16 citation statements)

References 28 publications

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“…This might also explain the lower number of women compared with men undergoing revascularisation. Previous reports of sex-related differences regarding evidence-based treatment are contradictory, some are in line with our findings, that is, women receiving less of modern treatment,6 21 22 others report no such pattern 19 23 24…”

Section: Discussionsupporting

confidence: 90%

Risk factors, treatment and prognosis in men and women with heart failure with and without diabetes

Johansson

Dahlström

Edner

et al. 2015

Heart

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Section: Discussionsupporting

confidence: 90%

Risk factors, treatment and prognosis in men and women with heart failure with and without diabetes

Johansson

Dahlström

Edner

et al. 2015

Heart

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“…The search resulted in 6167 citations. In total, 28 articles from 25 study populations (three studies wrote separate reports on systolic and diastolic ventricular dysfunction) were included in our systematic review . Two articles were found by screening of the reference lists.…”

Section: Resultsmentioning

confidence: 99%

Epidemiology of heart failure: the prevalence of heart failure and ventricular dysfunction in older adults over time. A systematic review

Riet

Hoes

Wagenaar

et al. 2016

European J of Heart Fail

589

354

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The 'epidemic' of heart failure seems to be changing, but precise prevalence estimates of heart failure and left ventricular dysfunction (LVD) in older adults, based on adequate echocardiographic assessment, are scarce. Systematic reviews including recent studies on the prevalence of heart failure and LVD are lacking. We aimed to assess the trends in the prevalence of LVD, and heart failure with reduced (HFrEF) and preserved ejection fraction (HFpEF) in the older population at large. A systematic electronic search of the databases Medline and Embase was performed. Studies that reported prevalence estimates in community-dwelling people ≥60 years old were included if echocardiography was used to establish the diagnosis. In total, 28 articles from 25 different study populations were included. The median prevalence of systolic and 'isolated' diastolic LVD was 5.5% (range 3.3-9.2%) and 36.0% (range 15.8-52.8%), respectively. A peak in systolic dysfunction prevalence seems to have occurred between 1995 and 2000. 'All type' heart failure had a median prevalence rate of 11.8% (range 4.7-13.3%), with fairly stable rates in the last decade and with HFpEF being more common than HFrEF [median prevalence 4.9% (range 3.8-7.4%) and 3.3% (range 2.4-5.8%), respectively]. Both LVD and heart failure remain common in the older population at large. The prevalence of diastolic dysfunction is on the rise and currently higher than that of systolic dysfunction. The prevalence of the latter seems to have decreased in the 21st century.

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“…The study population has previously been described in detail (20). Briefly, a rural municipality with 10 300 inhabitants situated in southeast Sweden was chosen.…”

Section: Methodsmentioning

confidence: 99%

Increased IGF1 levels in relation to heart failure and cardiovascular mortality in an elderly population: impact of ACE inhibitors

Chisalita¹,

Dahlström²,

Arnqvist³

et al. 2011

European Journal of Endocrinology

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Objective: There are conflicting results regarding the association of circulating IGF1 with cardiovascular (CV) morbidity and mortality. We assessed the relationship between IGF1 levels and heart failure (HF), ischemic heart disease (IHD), and CV mortality in an elderly population taking into account the possible impact of angiotensin converting enzyme (ACE) inhibitors. Design and methods: A total of 851 persons aged 66-81 years, in a rural Swedish municipality, were subjected to medical history, clinical examination, electrocardiography, echocardiography, and fasting plasma samples. They were then followed for 8 years. Results and conclusion: Patients on ACE inhibitors had higher IGF1 levels compared with those without ACE inhibitors. In patients on ACE inhibitors, higher IGF1 values were found in patients with an ejection fraction (EF) !40% compared with EF R40%, in patients with higher proBNP levels in quartile 4 vs 1, and in patients with IHD when compared to those without ACE inhibitors (P!0.001). In patients without ACE inhibitors, no relationship was found between IGF1 levels and HF or IHD. In multivariate regression, only ACE inhibitors, ECG changes characteristic for IHD, and gender had a significant impact on IGF1. Patients with higher IGF1 levels in quintiles 4 and 5 compared to quintiles 1 and 2 had a 50% higher risk for CV death (PZ0.03). This was significant after adjustment for wellknown CV risk factors and ACE inhibitors (PZ0.03). Conclusions: Our results show that treatment with ACE inhibitors in an elderly population is associated with increased IGF1 levels, especially in patients with impaired cardiac function or IHD. High IGF1 levels tend to be associated with an increased risk for CV mortality.

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Are There Any Significant Differences Between Females and Males in the Management of Heart Failure? Gender Aspects of an Elderly Population With Symptoms Associated With Heart Failure

Cited by 19 publications

References 28 publications

Risk factors, treatment and prognosis in men and women with heart failure with and without diabetes

Risk factors, treatment and prognosis in men and women with heart failure with and without diabetes

Epidemiology of heart failure: the prevalence of heart failure and ventricular dysfunction in older adults over time. A systematic review

Increased IGF1 levels in relation to heart failure and cardiovascular mortality in an elderly population: impact of ACE inhibitors

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