Are there any gender differences in the hippocampus volume after head-size correction? A volumetric and voxel-based morphometric study

Perlaki, Gábor; Orsi, G.; Plózer, Enikő; Altbäcker, Anna; Darnai, Gergely; Nagy, Szilvia Anett; Horváth, Réka; Tóth, Arnold; Dóczi, Tamás; Kovács, Norbert; Bogner, Péter; Schwarcz, Attila; Janszky, József

doi:10.1016/j.neulet.2014.04.013

Cited by 80 publications

(46 citation statements)

References 28 publications

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“…The present results suggest the contribution of specific cytoarchitectonically identified areas, namely s24 and s32, to these regional gender differences, and may shed light on the neurobiologic substrates of behavioral gender differences in healthy volunteers. Since male brains are larger than female brains, it is important to control the gender difference for the effect of absolute brain size (Luders et al, 2014; Perlaki et al, 2014). In the present study, s32 and s24 were larger in the brains of males than in those of females even after correction for absolute brain size.…”

Section: Discussionmentioning

confidence: 99%

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Functional organization of human subgenual cortical areas: Relationship between architectonical segregation and connectional heterogeneity

et al. 2015

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Human subgenual anterior cingulate cortex (sACC) is involved in affective experiences and fear processing. Functional neuroimaging studies view it as a homogeneous cortical entity. However, sACC comprises several distinct cyto- and receptorarchitectonical areas: 25, s24, s32, and the ventral portion of area 33. Thus, we hypothesized that the areas may also be connectionally and functionally distinct. We performed structural post mortem and functional in vivo analyses. We computed probabilistic maps of each area based on cytoarchitectonical analysis of ten post mortem brains. Maps, publicly available via the JuBrain atlas and the Anatomy Toolbox, were used to define seed regions of task-dependent functional connectivity profiles and quantitative functional decoding. sACC areas presented distinct co-activation patterns within widespread networks encompassing cortical and subcortical regions. They shared common functional domains related to emotion, perception and cognition. A more specific analysis of these domains revealed an association of s24 with sadness, and of s32 with fear processing. Both areas were activated during taste evaluation, and co-activated with the amygdala, a key node of the affective network. s32 co-activated with areas of the executive control network, and was associated with tasks probing cognition in which stimuli did not have an emotional component. Area 33 was activated by painful stimuli, and co-activated with areas of the sensorimotor network. These results support the concept of a connectional and functional specificity of the cyto- and receptorarchitectonically defined areas within the sACC, which can no longer be seen as a structurally and functionally homogeneous brain region.

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Section: Discussionmentioning

confidence: 99%

“…Prior to this analysis, all areal volumes were expressed as a fraction of total brain volume for each brain in order to adjust for differences in total brain size, i.e. we searched for true gender differences (Luders et al, 2014; Perlaki et al, 2014). …”

Section: Methodsmentioning

confidence: 99%

Functional organization of human subgenual cortical areas: Relationship between architectonical segregation and connectional heterogeneity

et al. 2015

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“…Multiple linear regression models were created for each structure as a dependent variable with all three subscales of PIUQ separately as an independent variable. Head correction was done using the statistical method: intracranial volume (ICV) was entered as additional independent variable (Perlaki et al 2014). To test whether problematic Internet use is associated with volumetric alterations in the reward system, multiple linear regression models were created for all three PIUQ subscales with each investigated region with the control of age and intracranial volume.…”

Section: Volumetric Analysismentioning

confidence: 99%

“…To identify structural brain changes MRI volumetry and VBM were used. These volumetric methods follow different approach and therefore enables different conclusions: while volumetry is based on automatic segmentation of brain regions, VBM provides "voxelwise overview of regional morphological effects" (Morey et al 2009;Good et al 2001;Keller & Roberts 2009;Perlaki et al 2014). Previous structural neuroimaging studies about Internet addiction used the VBM approach.…”

Section: Vbmmentioning

confidence: 99%

Problematic internet use is associated with structural alterations in the brain reward system in females

Altbäcker

Plózer

Darnai

et al. 2015

Brain Imaging and Behavior

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Neuroimaging findings suggest that excessive Internet use shows functional and structural brain changes similar to substance addiction. Even though it is still under debate whether there are gender differences in case of problematic use, previous studies by-passed this question by focusing on males only or by using gender matched approach without controlling for potential gender effects. We designed our study to find out whether there are structural correlates in the brain reward system of problematic Similarly, VBM analysis revealed a significant negative association between the absolute amount of grey matter OFC and problematic Internet use. Our findings suggest structural brain alterations in the reward system usually related to additions are present in problematic Internet use.

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“…26,27 Meta-analysis demonstrated reduced hippocampus volume in many neuropsychiatric disorders commonly found in women. 27 Therefore, researchers assumed that the smaller hippocampus volume of women contributed to increased vulnerability of neuropsychiatric disorders.…”

Section: Hippocampusmentioning

confidence: 99%

Brain morphology according to age, sex, and handedness

Kang

Jang

et al. 2017

Ann Clin Neurophysiol

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Are there any gender differences in the hippocampus volume after head-size correction? A volumetric and voxel-based morphometric study

Cited by 80 publications

References 28 publications

Functional organization of human subgenual cortical areas: Relationship between architectonical segregation and connectional heterogeneity

Functional organization of human subgenual cortical areas: Relationship between architectonical segregation and connectional heterogeneity

Problematic internet use is associated with structural alterations in the brain reward system in females

Brain morphology according to age, sex, and handedness

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