Are the new moisturizers more effective?

Anderson, Paul B.; Dinulos, James G.

doi:10.1097/mop.0b013e32832cfd3b

Cited by 31 publications

(26 citation statements)

References 11 publications

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“…1f). The beneficial effect of the Lactococcus lysate seems to overlap with vehicle effects associated with the moisturizing constituents glycerin, hyaluronic acid, and lactic acid [31] (Table 1). The effects caused by the vehicle seem to be more pronounced than the result obtained with a urea-ceramide-lactate-based formulation, which was previously proposed for the treatment of dry skin [32].…”

Section: Discussionmentioning

confidence: 99%

Reconstructed Human Epidermis Predicts Barrier-Improving Effects of Lactococcus lactis Emulsion in Humans

Hausmann

Hertz-Kleptow

Zoschke

et al. 2019

Skin Pharmacol Physiol

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Background/Aims: The skin provides protection against chemical, physical, and biological stressors, yet the skin morphology changes over the course of life. These changes might affect the skin barrier function and facilitate the onset of age-related diseases. Since orally applied lactic acid bacteria ameliorate signs of aged and atopic skin, we investigated the effects of a topically applied Lactococcus lactis emulsion. Methods: In a blinded, randomized, vehicle-controlled trial, we studied topical Lactococcus effects both in vitro and in 20 healthy female volunteers. Commercially available reconstructed human epidermis (RHE) was treated for 4 days (once daily) and volar forearms were treated for 30 days (twice daily). Results: Lactococcus formulations improve the skin barrier in RHE as shown by increased filaggrin and human β-defensin-2 expression as well as by the 23% declined mean apparent permeability coefficients for caffeine. A reduction of 18% in transepidermal water loss confirms this effect in humans. Moreover, Lactococcus emulsion optimized skin hydration and surface pH. Skin irritation was not detected. Conclusions: Lactococcus emulsion improved the skin barrier function with good biocompatibility. Moreover, our study exemplifies the translational predictive capacity of testing on RHE with respect to Lactococcus emulsion.

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Section: Discussionmentioning

confidence: 99%

Reconstructed Human Epidermis Predicts Barrier-Improving Effects of Lactococcus lactis Emulsion in Humans

Hausmann

Hertz-Kleptow

Zoschke

et al. 2019

Skin Pharmacol Physiol

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“…We can apply this phenomenon more practically to therapy than immunologic alterations. Maintaining skin hydration by supplementing the epidermal barrier defect is the most important part of AD therapy in terms of this barrier correction [24]. …”

Section: Pathogenesismentioning

confidence: 99%

“…Bathing hydrates skin, and removes possible allergens and irritants. Moisturizing immediately after bath further increases moisture contents of the skin, and can reduce the amount of topical steroids applied [24]. General recommendation for bathing is once daily with tepid water for approximately 10 to 20 minutes.…”

Section: Treatmentsmentioning

confidence: 99%

Overview of atopic dermatitis

Kim

2013

Asia Pacific Allergy

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Atopic dermatitis (AD) is a very common chronic disease that reportedly affects 10%-20% of the general population. The prevalence of AD appears to be steadily increasing, at least in developing countries. Two pathogenetic mechanisms have been mentioned. Traditionally immunological aberrations are thought to be a primary event in the initial development of AD ("inside-to-outside hypothesis"). Another hypothesis assumes that there is an intrinsic defect in epidermal barrier. Due to this barrier defect, allergens or irritants can easily penetrate the epidermal barrier, and induce immunologic reaction secondarily ("outside-to-inside hypothesis"). These days the epidermal barrier defect seems to gain more support as a primary event than immunological aberrations in the early changes of AD since the filaggrin mutation was reported in AD patients. Clinically AD initially affects face, and with age, flexural areas are typically involved. AD has many different clinical features. Diagnostic criteria for AD in each country may be a little different, although based on the criteria proposed by Hanifin and Rajka. AD can be controlled effectively with topical and/or systemic treatments and fortunately spontaneously disappears with age. However, in some cases very resistant to conventional therapies, additional treatments such as immunosuppressive agents are needed.

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“…Some also think that humectants are able to hydrate the stratum corneum by absorbing water from the external environment (11). Some also think that humectants are able to hydrate the stratum corneum by absorbing water from the external environment (11).…”

Section: Humectantsmentioning

confidence: 99%

Moisturizers: Reality and the skin benefits

Nolan

Marmur

2012

Dermatol Ther

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The function of the skin as a barrier protects underlying tissues from infection, desiccation, chemicals, and mechanical stress. Disruption of this function results in increased transepidermal water loss or TEWL and is associated with conditions like atopic dermatitis and other chronic skin diseases. Moisturizers have been shown to improve these conditions through restoration of the integrity of the stratum corneum, acting as a barrier to water loss and replacement of skin lipids and other compounds. Also, moisturizers are commonly used to reduce fine lines and make skin appear smooth and soft. While many products make extensive claims of skin rejuvenation, many of the beneficial effects of these products are actually due to the moisturizers they contain: ingredients like glycerin, petrolatum, and dimethicone. Some newer formulations like prescription-device moisturizers, which received 510 K approval on the basis of reducing TEWL, are significantly more expensive than traditional moisturizers and recent literature does not indicate that they are more effective than their over-the-counter counterparts.

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Are the new moisturizers more effective?

Cited by 31 publications

References 11 publications

Reconstructed Human Epidermis Predicts Barrier-Improving Effects of <b><i>Lactococcus lactis</i></b> Emulsion in Humans

Reconstructed Human Epidermis Predicts Barrier-Improving Effects of <b><i>Lactococcus lactis</i></b> Emulsion in Humans

Overview of atopic dermatitis

Moisturizers: Reality and the skin benefits

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