Are the effects of cognitive remediation therapy (CRT) durable? Results from an exploratory trial in schizophrenia

Cognitive rehabilitation of the updating sub-component of working memory in schizophrenia: A case study

“…This is not in accordance with the only two studies (Wykes et al, 1999(Wykes et al, , 2003, two studies that included the same participants) that had previously examined this question, which found that a cognitive rehabilitation programme had a positive effect on self-esteem. Wykes et al (1999) note that this observed beneficial effect may be due, at least in part, to the fact that patients were able to perceive their increased performance thanks to the use of such techniques as errorless learning.…”

“…Moreover, a significant decrease in negative symptoms (social withdrawal and apathy) was observed after the entire cognitive rehabilitation programme. Several earlier studies have also found a relationship between working memory deficits and negative symptoms (e.g., Reeder et al, 2004;Twamley, Palmer, Jeste, Taylor, & Heaton, 2006) and others have observed the beneficial effect of a cognitive rehabilitation programme on negative symptoms (e.g., Cochet et al, 2006;Medalia, Dorn, & WatrasGans, 2000;Wykes, Reeder, Corner, Williams, & Everitt, 1999;Wykes et al, 2003). Nevertheless, the mechanisms underlying the beneficial effects of a cognitive rehabilitation programme on (negative) symptom severity have not been directly examined in the scientific literature, although Greenwood, Landau, and Wykes (2005) provided an interesting account of the possible mechanisms involved in interactions between negative symptoms and cognition in predicting community functioning.…”

Avaliação neuropsicológica na esquizofrenia: revisão sistemática

“…Entre os 77 estudos, foi possível identificar as seguintes categorias: (1) estudos sobre diferentes aspectos relacionados ao funcionamento cognitivo (n = 23) 6,10,12,15,20,21,23,25,29,32,35,38,41,43,44,48,54,57,61,62,66,67,77 ; (2) validação de instrumentos e baterias de testes neuropsicológicos (n = 22) [7][8][9]17,18,24,30,36,39,40,47,51,55,56,[63][64][65]68,70,73,75,79 ; (3) avaliação de sinais neuropsicológicos e do efeito do tempo sobre cognição (n = 13) 14,16,31,33,…”

Addressing Cognitive Challenges in Schizophrenia: A Public Health Perspective

“…Not surprisingly, the response to cognitive training response is associated with structural and functional changes in prefrontal area of the brain [10,11]. The gains of cognitive training are likely to be durable for several months beyond the training period [12,13]. The gains of cognitive training interventions go beyond mere improvement in performance in cognitive tests-patients show improvement in measures of everyday functioning also.…”

“…An interesting finding of the meta-analyses of cognitive training in schizophrenia was that the interventions generally worked better if they were combined with other measures of psychiatric rehabilitation like vocational training and/or supported employment services [8,13,21]. This suggests an interesting interaction between psychiatric rehabilitative interventions and cognitive training.…”