Are somatosensory evoked potentials of the tibial nerve the most sensitive test in diagnosing multiple sclerosis?

Djuric, Stojanka; Djuric, Vanja; Zivkovic, Milan; Milošević, Verica; Jolic, M.; Stamenović, Jelena; Djordjević, Goran T.; Machado, Calixto

doi:10.4103/0028-3886.68669

Cited by 11 publications

(12 citation statements)

References 20 publications

(27 reference statements)

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“…Yaldizli et al were able to explain 56% of EDSS variance after mean of 7.1 years by using EDSS at diagnosis along with other clinical and MRI variables, while Deloire et al explained 56 and 71% of EDSS change at 5 and 7 years, respectively, using EDSS at baseline and age along with either Symbol Digit Modalities Test or consistent long-term retrieval [16,17]. Due to major differences in patients' characteristics, methods and regressor variables, none of the preceding works are directly comparable with ours; noteworthy, neurophysiological variables have been never included as regressors in spite of being still widely used to diagnose and monitor the disease [18,19]. Nonetheless, a generalized difficulty in accurate long-term prediction of disability with multivariate models seems to emerge.…”

Section: Discussionmentioning

confidence: 49%

Sensory evoked potentials to predict short-term progression of disability in multiple sclerosis

et al. 2011

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To devise a multivariate parametric model for short-term prediction of disability using the Expanded Disability Status Scale (EDSS) and multimodal sensory EP (mEP). A total of 221 multiple sclerosis (MS) patients who underwent repeated mEP and EDSS assessments at variable time intervals over a 20-year period were retrospectively analyzed. Published criteria were used to compute a cumulative score (mEPS) of abnormalities for each of 908 individual tests. Data of a statistically balanced sample of 58 patients were fed to a parametrical regression analysis using time-lagged EDSS and mEPS along with other clinical variables to estimate future EDSS scores at 1 year. Whole sample cross-sectional mEPS were moderately correlated with EDSS, whereas longitudinal mEPS were not. Using the regression model, lagged mEPS and lagged EDSS along with clinical variables provided better future EDSS estimates. The R (2) measure of fit was significant and 72% of EDSS estimates showed an error value of ±0.5. A parametrical regression model combining EDSS and mEPS accurately predicts short-term disability in MS patients and could be used to optimize decisions concerning treatment.

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Section: Discussionmentioning

confidence: 49%

Sensory evoked potentials to predict short-term progression of disability in multiple sclerosis

et al. 2011

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“…La mayor alteración fue encontrada en PESS de nervio tibial posterior y mediano y resultados similares a los nuestros se encontraron para el PEV y el PEATC. 19 Con respecto a la naturaleza de las lesiones, los resultados de los estudios electrofisiológicos de los pacientes incluidos en este trabajo se correspondieron con lo reportado por otros autores, [20][21][22] encontrando que la mayor parte de las alteraciones estuvieron referidas a las variables que denotan la existencia de un daño desmielinizante (latencia absoluta, intervalos interpicos, distorsión morfológica y ausencia de componentes). Nuevamente se registró el mayor porcentaje de anomalías en los potenciales que exploran las vías más largas (somestésica y visual) que se manifiestan fundamentalmente por la afectación de latencia y distorsión morfológica, referido a la afectación de la mielina, característica preponderante de esta enfermedad.…”

Section: Discusión De Los Resultadosunclassified

Puntaje Global de Potenciales Evocados Multimodales Sensoriales en el Estudio de Pacientes Con Esclerosis Múltiple.

et al. 2020

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Introducción: La Esclerosis Múltiple (EM) es una enfermedad desmielinizante, inflamatoria y neurodegenerativa del sistema nervioso central, en la que se han utilizado los Potenciales Evocados Multimodales Sensoriales (PEMS) para evaluar la integridad de las vías sensoriales, pero no se han considerado sus resultados para el diagnóstico de la enfermedad. Objetivo: evaluar la relación del puntaje global de PEMS con la magnitud de la discapacidad y la presencia de lesiones en las imágenes de resonancia magnética de pacientes con EM. Métodos: se estudiaron 35 pacientes con EM forma clínica recaídaremisión en el Centro Internacional de Restauración Neurológica. Se correlacionó el puntaje global de los PEMS con la escala de discapacidad de Kurtzke y con las lesiones encontradas en la s imágenes de resonancia magnética. Resultados: se observó una correlación significativa entre el puntaje global y la escala de discapacidad (R=0.33, p< 0.05), y entre este puntaje global y el número de niveles de lesiones detectadas en las imágenes de resonancia (R= 0.42, p< 0.05). Conclusiones: La relación del puntaje global de los PEMS con las lesiones estructurales y el grado de discapacidad confirma su utilidad para el estudio de los pacientes con EM, aun cuando no forman parte de los criterios diagnósticos.

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“…The diagnostic value of SSEP is most pronounced in diagnostic evaluation of patients with no evidence of demyelinating lesions on the spinal MRI. Tibial SSEP is considered to be among the most valuable EPs (14), giving pathological findings in up to 80% of patients with MS who do not have sensory symptoms and signs (15).…”

Section: Evoked Potentials In Multiple Sclerosismentioning

confidence: 99%

Clinical Neurophysiology of Multiple Sclerosis

Habek

Adamec

Barun

et al. 2017

Multiple Sclerosis: Bench to Bedside

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Different neurophysiological methods such as evoked potentials (EP), testing of the autonomic nervous system (ANS) or polysomnography have the potential to detect clinically silent lesions or to confirm the existence of an association between a clinical symptom and multiple sclerosis (MS); previously undetected by MRI. Therefore, in the most recent MRI criteria for the diagnosis of MS (MAGNIMS consensus guidelines), neurophysiological confirmation of optic nerve dysfunction (slowed conduction on visual EP), support dissemination in space and, in patients without concurrent visual symptoms, dissemination in time. In this chapter we will review the existing evidence regarding the role of different neurophysiological tests (specifically the role of EPs, autonomic nervous system testing and sleep testing in MS) in the diagnosis and management of MS.

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Are somatosensory evoked potentials of the tibial nerve the most sensitive test in diagnosing multiple sclerosis?

Abstract: Tibial SEPs produce the most abnormal results and the highest sensitivity in the RR-MS. We propose that this test as useful criterion for the diagnosis of MS.

Cited by 11 publications

References 20 publications

Sensory evoked potentials to predict short-term progression of disability in multiple sclerosis

Sensory evoked potentials to predict short-term progression of disability in multiple sclerosis

Puntaje Global de Potenciales Evocados Multimodales Sensoriales en el Estudio de Pacientes Con Esclerosis Múltiple.

Clinical Neurophysiology of Multiple Sclerosis

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