Are slaughterhouse-obtained livers suitable for use in ex vivo perfusion research?
Alicia Ruppelt,
Iris Pijnenburg,
Claire Pappers
et al.
Abstract:Objectives The success of the ex vivo machine perfusion of pig livers used for preclinical research depends on organ quality and availability. In this study, we investigated whether livers obtained from slaughterhouses are suitable and equivalent to livers obtained from laboratory pigs. Methods Livers were obtained from slaughterhouse pigs stunned by electrocution or CO2 inhalation and from laboratory pigs. For the latter group, 45 minutes of warm ischemia was mimicked for a subgroup, ensuring a valid comparis… Show more
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