Are reported stress and coping style associated with frequent recurrence of genital herpes?

Cassidy, Linda; Meadows, Jean; Catalán, José; Barton, Simon

doi:10.1136/sti.73.4.263

Cited by 24 publications

(44 citation statements)

References 24 publications

(4 reference statements)

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“…Periodically, reactivation from latency occurs, which is crucial for virus transmission. In general, increased "stress" correlates with a higher incidence of reactivation from latency in humans (Cassidy et al, 1997;Glaser et al, 1985;Padgett et al, 1998). In keeping with these observations, the synthetic corticosteroid dexamethasone accelerates reactivation from latency in TG neuronal cultures or TG organ cultures prepared from mice latently infected with HSV-1 (Du et al, 2012;Halford et al, 1996).…”

Section: Introductionmentioning

confidence: 58%

The serum and glucocorticoid-regulated protein kinases (SGK) stimulate bovine herpesvirus 1 and herpes simplex virus 1 productive infection

Kook

Jones

2016

Virus Research

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Serum and glucocorticoid-regulated protein kinases (SGK) are serine/threonine protein kinases that contain a catalytic domain resembling other protein kinases: AKT/protein kinase B, protein kinase A, and protein kinase C-Zeta for example. Unlike these constitutively expressed protein kinases, SGK1 RNA and protein levels are increased by growth factors and corticosteroids. Stress can directly stimulate SGK1 levels as well as stimulate bovine herpesvirus 1 (BoHV-1) and herpes simplex virus 1 (HSV-1) productive infection and reactivation from latency suggesting SGK1 can stimulate productive infection. For the first time, we provide evidence that a specific SGK inhibitor (GSK650394) significantly reduced BoHV-1 and HSV-1 replication in cultured cells. Proteins encoded by the three BoHV-1 immediate early genes (bICP0, bICP4, and bICP22) and two late proteins (VP16 and gE) were consistently reduced by GSK650394 during early stages of productive infection. In summary, these studies suggest SGK may stimulate viral replication following stressful stimuli.

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Section: Introductionmentioning

confidence: 58%

The serum and glucocorticoid-regulated protein kinases (SGK) stimulate bovine herpesvirus 1 and herpes simplex virus 1 productive infection

Kook

Jones

2016

Virus Research

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“…Findings on the contribution of stress are "contradictory and inconclusive". Cassidy et al (1997) did not find any relation between recurrence of genital herpes and anxiety, depression, health locus of control, personality, or social support, but found that active problem-and emotion-focused coping strategies are more likely to be of value in coping with herpetic recurrence. Stronks et al (1993) found that during active symptoms HSV ‡ patients show more anxiety, lower self esteem, have more psychological complaints, more sexual inhibition and greater bitterness toward their partners.…”

Section: Psychological Reactions To Hsv ‡ Diagnosismentioning

confidence: 76%

Doing Psychotherapy with Patients with Genital Herpes: Issues and Interventions

Zacharioudakis

2001

Scandinavian Journal of Behaviour Therapy

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This article presents issues that the psychotherapist is likely to have to deal with in treating patients with genital herpes. A review of medical issues, clinical manifestations and pharmacotherapy of herpes infections is presented. Common psychological reactions and psychopatholog y related to herpes simplex virus infection, a discussion of the patient's dilemma of disclosing his or her herpes simplex positive status to others and a list of cognitive-logical distortions often encountered in, and negatively affecting, patients with genital herpes are presented in detailed examples. A practical model (SANE) conceptualizing psychotherapy for patients with genital herpes in 4 intervention stages (Stabilization-crisis intervention, Acceptance, Normalization and social-personal Empowerment-evolution) is suggested for use. The use of cognitive-behavioral therapeutic strategies in facilitating the patient's assumption of a healthier psychosocial perspective in each stage is comprehensively detailed. Ethical and legal concerns in working with herpes simplex positive patients are also discussed.

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“…Herpes simplex esteem, and resultant flight in the face of an imminent sexual relationship (Cassidy et al 1997).…”

Section: Hsv-1 Recurrences May Be Elicited By Emotional Stress !mentioning

confidence: 99%

Clinical Management in Psychodermatology

2009

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Are reported stress and coping style associated with frequent recurrence of genital herpes?

Abstract: Objectives: This paper reports on the cross sectional data from the longitudinal study examining the impact of genital herpes simplex virus (HSV) infection on quality of life. In particular the report sought to study the

Cited by 24 publications

References 24 publications

The serum and glucocorticoid-regulated protein kinases (SGK) stimulate bovine herpesvirus 1 and herpes simplex virus 1 productive infection

The serum and glucocorticoid-regulated protein kinases (SGK) stimulate bovine herpesvirus 1 and herpes simplex virus 1 productive infection

Doing Psychotherapy with Patients with Genital Herpes: Issues and Interventions

Clinical Management in Psychodermatology

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