Are REM Cycles in Narcoleptic Patients Governed by an Ultradian Rhythm?

J, De Koninck; Mq, Salva; Besset, A; Billiard, Michel

doi:10.1093/sleep/9.1.162

Cited by 14 publications

(11 citation statements)

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“…De Koninck et al has pointed out that night‐time REM episodes in narcoleptic patients tend to fall within the same periodicity as that of their preceding daytime episodes 4 . Our results partly corroborate that finding.…”

Section: Discussionsupporting

confidence: 90%

Analysis of rapid eye movement periodicity in narcoleptics based on maximum entropy method

Honma

Ohtomo

Kohsaka

et al. 1999

Psychiatry Clin Neurosci

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We examined REM sleep periodicity in typical narcoleptics and patients who had shown signs of a narcoleptic tetrad without HLA-DRB1*1501/DQB1*0602 or DR2 antigens, using spectral analysis based on the maximum entropy method. The REM sleep period of typical narcoleptics showed two peaks, one at 70-90 min and one at 110-130 min at night, and a single peak at around 70-90 min during the daytime. The nocturnal REM sleep period of typical narcoleptics may be composed of several different periods, one of which corresponds to that of their daytime REM sleep.

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Section: Discussionsupporting

confidence: 90%

Analysis of rapid eye movement periodicity in narcoleptics based on maximum entropy method

Honma

Ohtomo

Kohsaka

et al. 1999

Psychiatry Clin Neurosci

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“…1976;Schultz 1985;De Koninck et al 1986). On the other hand, the behaviour of the REM sleep oscillator could be supposed strictly sleep-dependent.…”

Section: Introductionmentioning

confidence: 99%

Sleep onset rapid‐eye‐movement episodes in narcolepsy: REM sleep pressure or nonREM‐REM sleep dysregulation?

Tafti

Villemin

Carlander

et al. 1992

Journal of Sleep Research

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SUMMARY Thirty-two narcoleptic subjects with excessive daytime sleepiness and cataplexy were recorded for 33 continuous hours. The continuous polysomnographic recording (CPSG) was followed by a standard MSLT at 2-h intervals. There were 64 sleep onset REM episodes (SOREMs) us 64 sleep onset nonREM episodes (SONREMs) during the CPSG, and 102 SOREMs us 50 SONREMS during the MSLT. Both sleep onset types peaked at 13-15 h during the CPSG while sleep onsets were evenly distributed during the MSLT. In the latter procedure, the mean sleep latency was significantly shorter with SOREMs occurrence than with SONREMs occurrence. Two factors were extracted in each procedure by means of a Varimax Rotated Factor Analysis. During the CPSG, SOREMs were related to the preceding nocturnal sleep parameters in the first factor, and to the daytime total sleep time and the total number of sleep onsets in the second factor. During the MSLT, SOREMs were related only to the mean sleep latency and the total number of sleep onsets. It was concluded that the occurrence of SOREMs is primarily due to the residual somnolence in narcoleptic subjects. However, their occurrence during the MSLT is largely independent of the prior history of sleep and waking. Thus, we propose a nonREM-REM sleep dysregulation hypothesis to account for the appearance of SOREMs in narcolepsy.KEYWORDS continuous polysomnographic recording (CPSG), multiple sleep latency test (MSLT), narcolepsy, nonREM-REM sleep dysregulation, REM sleep pressure, sleep onset rapid-eye-movement episodes (SOREMs)

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“…All-night absolute EEG power spectra (0.75-20 Hz) in NREM sleep (stages 2, 3, and 4) in both groups showed high power in the delta-frequency band (0.75-5 Hz) and a secondary peak in the sigma band (12)(13)(14)(15). Power densities were lower in REM sleep.…”

Section: All-night Eeg Power Spectra and Changes In Eeg Power Over Comentioning

confidence: 94%

“…(3) NREM sleep homeostasis is intact but controlled by a predominant ultradian rhythm. 3,12,13 During a prolonged bed-rest condition of 32 hours with sleep ad libitum, peaks of SWA occurred every 4 hour. This temporal pattern of SWA distribution is thought to reflect a strong ultradian sleep drive that contributes to sleep-wake dysregulation in patients with narcolepsy-cataplexy.…”

Section: Narcolepsymentioning

confidence: 99%

“…Cataplexy was considered to be definite according to proposed standard criteria. 14,15 The patients' Epworth Sleepiness score 16 was 15.1 ± 3.0 (mean ± SD; range: 10-19], the Ullanlinna Narcolepsy Scale 17 was 20.9 ± 5.7 (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27), the Swiss narcolepsy scale 15 was -42 ± 25.4 (-6 to -70) and the Stanford cataplexy scale 14 showed a mean of 69.3% ± 24.6% (45.8%-91.7%). HLA typing was available in 9 of 11 patients and was positive for HLA-DQB1*0602 in all 9 patients tested.…”

Section: Subjects and Study Protocolmentioning

confidence: 99%

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