Are Psychotic Psychopathology and Neurocognition Orthogonal? A Systematic Review of Their Associations

Domínguez, Mayelín; Viechtbauer, Wolfgang; Simons, Claudia; Os, Jim van; Krabbendam, Lydia

doi:10.1016/s0920-9964(08)70357-8

Cited by 11 publications

(12 citation statements)

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“…More specifically, several investigators have reported no significant differences in positive and negative symptom severities between patients with intellectual or cognitive impairments and patients with relatively normal intellect or cognition Holthausen et al, 2002;Kremen et al, 2000;Palmer et al, 1997;Vaskinn et al, 2014). More recent reviews have substantiated previous reports that associations between psychopathology, especially psychotic symptoms, and many standard cognitive tasks used in clinical neuropsychology, are unimpressive and often absent in schizophrenia (Berenbaum et al, 2008;Dibben et al, 2009;Dominguez et al, 2009). However, these findings contradict numerous studies linking low IQ or cognitive impairment with negative symptoms (e.g., Aleman et al, 1999;Ammari et al, 2010;Basso et al, 1998;Cameron et al, 2002;Cobia et al, 2011;Leeson et al, 2010;Moritz et al, 2001;Nieuwenstein et al, 2001;Stirling, Hellewell, & Hewitt, 1997;Wells et al, 2015).…”

Section: Cognition and Psychopathologymentioning

confidence: 93%

Preserved, deteriorated, and premorbidly impaired patterns of intellectual ability in schizophrenia.

Ammari¹,

Heinrichs²,

Pinnock³

et al. 2014

Neuropsychology

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Objective: Although impaired general intellectual ability is a prevalent feature in schizophrenia, patterns suggesting preserved, deteriorated, and premorbidly impaired intellect have also been identified. The main purpose of this investigation was to examine the clinical, cognitive, and neuroanatomical characteristics of these intellectual subtypes, and to establish the value and validity of this approach for reducing the heterogeneity of schizophrenia. Methods: A total of 71 patients with a diagnosis of schizophrenia or schizoaffective disorder and 66 healthy controls were assessed. A 'preserved' performance pattern (n=29) was defined by average-range estimated premorbid and current IQ with no evidence of decline (premorbid-current IQ difference <10 points). A 'deteriorated' pattern (n=14) was defined by a difference between estimated premorbid and current IQ estimates of 10 points or more. A 'premorbidly impaired' pattern (n=14) was defined by below average estimated premorbid and current IQ and no evidence of decline greater than 10 points. The groups were compared on demographic,

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Section: Cognition and Psychopathologymentioning

confidence: 93%

Preserved, deteriorated, and premorbidly impaired patterns of intellectual ability in schizophrenia.

Ammari¹,

Heinrichs²,

Pinnock³

et al. 2014

Neuropsychology

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“…Neuropsychological deficits are highly prevalent in schizophrenia and bipolar disorder (Daban et al, 2006;Krabbendam et al, 2005;Seidman et al, 2010) and other psychoses, such as schizoaffective disorder (Reichenberg et al, 2009). Although there is still considerable debate regarding the extent to which cognitive deficits and psychopathological symptoms are related, recent reviews and meta-analyses suggest that cognitive impairment and symptoms in schizophrenia are independent or semi-independent dimensions of the illness, since only small to medium significant statistical associations between negative and disorganization dimensions of psychosis and cognitive impairment have been found (Dominguez et al, 2009;Nieuwenstein et al, 2001;Ventura et al, 2000).…”

Section: Schizophrenia Researchmentioning

confidence: 99%

Brief cognitive assessment instruments in schizophrenia and bipolar patients, and healthy control subjects: A comparison study between the Brief Cognitive Assessment Tool for Schizophrenia (B-CATS) and the Screen for Cognitive Impairment in Psychiatry (SCIP)

Cuesta

Pino

Guilera

et al. 2011

Schizophrenia Research

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Cognitive impairment in schizophrenia and psychosis is ubiquitous and acknowledged as a core feature of clinical expression, pathophysiology, and prediction of functioning. However, assessment of cognitive functioning is excessively time-consuming in routine practice, and brief cognitive instruments specific to psychosis would be of value. Two screening tools have recently been created to address this issue, i.e., the Brief Cognitive Assessment Tool for Schizophrenia (B-CATS) and the Screen for Cognitive Impairment in Psychiatry (SCIP). The aim of this research was to examine the comparative validity of these two brief instruments in relation to a global cognitive score. 161 patients with psychosis (96 patients diagnosed with schizophrenia and 65 patients diagnosed with bipolar disorder) and 76 healthy control subjects were tested with both instruments to examine their concurrent validity relative to a more comprehensive neuropsychological assessment battery. Scores from the B-CATS and the SCIP were highly correlated in the three diagnostic groups, and both scales showed good to excellent concurrent validity relative to a Global Cognitive Composite Score (GCCS) derived from the more comprehensive examination. The SCIP-S showed better predictive value of global cognitive impairment than the B-CATS. Partial and semi-partial correlations showed slightly higher percentages of both shared and unique variance between the SCIP-S and the GCCS than between the B-CATS and the GCCS. Brief instruments for assessing cognition in schizophrenia and bipolar disorders, such as the SCIP-S and B-CATS, seem to be reliable and promising tools for use in routine clinical practice.

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“…In terms of clinical symptomatology, cognitive deficits are proposed to be more closely associated with negative and disorganised aspects of psychosis compared with positive symptoms (Bora and Murray, 2013;Dominguez et al, 2009). Attention, psychomotor speed and verbal learning in particular have been found to correlate with negative symptoms in schizophrenia (August et al, 2012;Bora and Murray, 2013;O'Gráda et al, 2009), while disorganised symptoms were related to lower verbal and visual learning, processing speed and social cognition (August et al, 2012;Flaum et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Cognitive course in first-episode psychosis and clinical correlates: A 4 year longitudinal study using the MATRICS Consensus Cognitive Battery

Kenney

Anderson‐Schmidt

Scanlon

et al. 2015

Schizophrenia Research

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While cognitive impairments are prevalent in first-episode psychosis, the course of these deficits is not fully understood. Most deficits appear to remain stable, however there is uncertainty regarding the trajectory of specific cognitive domains after illness onset. This study investigates the longitudinal course of cognitive deficits four years after a first-episode of psychosis and the relationship of performance with clinical course and response to treatment.Twenty three individuals with psychotic illness, matched with 21 healthy volunteers, were assessed using the MATRICS Consensus Cognitive Battery at illness onset and 4 years later. We also investigated the relationship between cognitive deficits and quality of life and clinical indices.Verbal learning and two measures of processing speed had marked poorer trajectory over four years compared to the remaining cognitive domains. Processing speed performance was found to contribute to the cognitive deficits in psychosis. Poorer clinical outcome was associated with greater deficits at illness onset in reasoning and problem solving and social cognition. Cognitive deficits did not predict quality of life at follow-up, nor did diagnosis subtype differentiate cognitive performance.In conclusion, an initial psychotic episode may be associated with an additional cost on verbal learning and two measures of processing speed over a time spanning at least four years. Moreover, processing speed, which has been manipulated through intervention in previous studies, may represent a viable therapeutic target. Finally, cognition at illness onset may have a predictive capability of illness course.

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Are Psychotic Psychopathology and Neurocognition Orthogonal? A Systematic Review of Their Associations

Cited by 11 publications

References 0 publications

Preserved, deteriorated, and premorbidly impaired patterns of intellectual ability in schizophrenia.

Preserved, deteriorated, and premorbidly impaired patterns of intellectual ability in schizophrenia.

Brief cognitive assessment instruments in schizophrenia and bipolar patients, and healthy control subjects: A comparison study between the Brief Cognitive Assessment Tool for Schizophrenia (B-CATS) and the Screen for Cognitive Impairment in Psychiatry (SCIP)

Cognitive course in first-episode psychosis and clinical correlates: A 4 year longitudinal study using the MATRICS Consensus Cognitive Battery

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