Are probiotics beneficial for obese patients with major depressive disorder? Opinion for future implications and strategies

Kaunang, Theresia M. D.; Setiawan, Aurielle Annalicia; Mayulu, Nelly; Leonita, Ivena; Wijaya, Afredo; Yusuf, Vincentius Mario; Mahira, Msy Firyal Nadya Al; Yudisthira, Dewangga; Gunawan, William Ben; Taslim, Nurpudji Astuti; Purnomo, Athaya Febriantyo; Sabrina, Nindy; Amalia, Nurlinah; Permatasari, Happy Kurnia; Nurkolis, Fahrul

doi:10.3389/fnut.2023.1205434

Cited by 4 publications

(3 citation statements)

References 69 publications

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“…Therefore, an imbalance in the intestinal microbiota can lead to changes in the production of these neurotransmitters and vitamins, negatively impacting mood and emotional health [23]. The use of probiotics has been suggested as a therapeutic strategy to create a balanced intestinal environment for the production of these essential substances in mental health [50].…”

Section: Discussionmentioning

confidence: 99%

Genomic Study of Intestinal Microbiota: Assessing the Impact of Probiotics and Healthy Lifestyle on Weight Loss in Adults with Obesity

FLORENCIO,

Xavier,

Natal

et al. 2024

Preprint

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Background and objective: Obesity is a growing global epidemic. The composition of the intestinal microbiota can be influenced by several factors. Studies highlight the role of intestinal bacteria in the pathophysiology of obesity. So, the objective of this study was to investigate whether the use of probiotics, together with healthy lifestyle habits, contributes to weight reduction in obese indi-viduals by analyzing the intestinal microbiota profile. Methods: A prospective study was carried out with 45 adults with obesity. Participants underwent guidance on healthy lifestyle habits, re-ceived a probiotic component containing different microbiological strains and were followed for 60 days. Clinical parameters, body composition, biochemical analysis and intestinal microbiota assessment were performed before and after treatment. After 60 days, it was observed that the bacterial strains present in the probiotic were present in the patients' intestinal microbiota. Par-ticipants also showed improvements in physical activity, sleep quality, anxiety management, as well as changes in some eating habits, such as a reduction in the consumption of processed foods and a significant increase in water intake. Results: A reduction in BMI, fasting glucose, insulin, HOMA-IR, LDL cholesterol and triglycerides was observed, in addition to an increase in HDL cholesterol, improvement in bowel movement frequency and stool consistency. Analysis of the intestinal microbiota revealed an increase in microbial diversity and a better balance between the bacterial phyla Firmicutes and Bacteroidetes. Conclusions: The changes related to improving the composition of the intestinal microbiota, dietary habits, increased physical activity, reduced anxiety, and better sleep quality have significantly contributed to weight loss and improvements in physiological parameters in obese individuals.

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Section: Discussionmentioning

confidence: 99%

Genomic Study of Intestinal Microbiota: Assessing the Impact of Probiotics and Healthy Lifestyle on Weight Loss in Adults with Obesity

FLORENCIO,

Xavier,

Natal

et al. 2024

Preprint

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“…The above findings are, as far as we know, new to the scientific world, as to the best of our knowledge metabolic parameters have not been assessed as determinants of the efficacy of probiotics for depression so far. Few studies have assessed the efficacy of probiotics in obese patients with depression, and the results are promising for depression but inconclusive for obesity [55]. Nonetheless, none of the trials compared the psychopathology outcomes of interventions between obese and lean subjects.…”

Section: %∆S-dass %∆Qol %∆Qolpsymentioning

confidence: 99%

Metabolic Status Influences Probiotic Efficacy for Depression—PRO-DEMET Randomized Clinical Trial Results

Gawlik-Kotelnicka,

Margulska,

Płeska

et al. 2024

Nutrients

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Probiotics may represent a safe and easy-to-use treatment option for depression or its metabolic comorbidities. However, it is not known whether metabolic features can influence the efficacy of probiotics treatments for depression. This trial involved a parallel-group, prospective, randomized, double-blind, controlled design. In total, 116 participants with depression received a probiotic preparation containing Lactobacillus helveticus Rosell®-52 and Bifidobacterium longum Rosell®-175 or placebo over 60 days. The psychometric data were assessed longitudinally at five time-points. Data for blood pressure, body weight, waist circumference, complete blood count, serum levels of C-reactive protein, cholesterol, triglycerides, and fasting glucose were measured at the beginning of the intervention period. There was no advantage of probiotics usage over placebo in the depression score overall (PRO vs. PLC: F(1.92) = 0.58; p = 0.45). However, we found a higher rate of minimum clinically important differences in patients supplemented with probiotics than those allocated to placebo generally (74.5 vs. 53.5%; X2(1,n = 94) = 4.53; p = 0.03; NNT = 4.03), as well as in the antidepressant-treated subgroup. Moreover, we found that the more advanced the pre-intervention metabolic abnormalities (such as overweight, excessive central adipose tissue, and liver steatosis), the lower the improvements in psychometric scores. A higher baseline stress level was correlated with better improvements. The current probiotic formulations may only be used as complementary treatments for depressive disorders. Metabolic abnormalities may require more complex treatments. ClinicalTrials.gov identifier: NCT04756544.

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“…The main reason for modern humans to take probiotics is for restoration of normal gut microbiota after antibiotic treatment. In fact, probiotics have a wide range of applications, as they have a proven effect against severe, difficult-to-treat diseases such as cancer [2,3], diabetes [4,5], 2 obesity [6][7][8], as well as involvement in the metabolism of lipids and carbohydrates [9], and can even affect the central nervous system and brain activity [10].…”

Section: Introductionmentioning

confidence: 99%

In vitro Effects of Postmetabolites from Limosilactobacillus fermentum 53 on the Survival and Proliferation of HT-29 Cells

Moskova-Doumanova,

Vaseva,

Veleva

et al. 2024

Preprint

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Naturally fermented dairy products are an important component of the human diet. They are a valuable source of nutrients as well as vitamins and minerals. Their importance as a source of probiotic bacterial strains should not be overlooked. A number of studies highlights the positive effects of species of the Lactobacillacea on the intestinal microbiota, the overall homeostasis of the body, as well as a complementary treatment for some diseases. However, data on the effects on intestinal epithelial cells of postmetabolites released by bacteria are incomplete. This is likely due to the fact that these effects are species and strain specific. In the present study, we investigated the effects of postmetabolites produced by a pre-selected candidate probiotic strain Limosilactobacillus fermentum on HT-29 intestinal epithelial cells. Our data showed a pronounced proliferative effect, evaluated by flow cytometry, quantification of cell population, and determination of mitotic index. This was accompanied by stabilization of the cell monolayer, measured by increase of TEER (trans epithelial electric resistance) and reorganization of actin filaments. The data obtained are a clear indication of the positive effects, that the products secreted by L. fermentum strain 53 have on the intestinal epithelial cells.

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Are probiotics beneficial for obese patients with major depressive disorder? Opinion for future implications and strategies

Cited by 4 publications

References 69 publications

Genomic Study of Intestinal Microbiota: Assessing the Impact of Probiotics and Healthy Lifestyle on Weight Loss in Adults with Obesity

Genomic Study of Intestinal Microbiota: Assessing the Impact of Probiotics and Healthy Lifestyle on Weight Loss in Adults with Obesity

Metabolic Status Influences Probiotic Efficacy for Depression—PRO-DEMET Randomized Clinical Trial Results

In vitro Effects of Postmetabolites from Limosilactobacillus fermentum 53 on the Survival and Proliferation of HT-29 Cells

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