Are platelet volume indices related to mortality in hospitalized children on mechanical ventilation?

Zhang, Yanyi; Zhang, Chenmei; Xu, Dan

doi:10.1177/0300060517737211

Cited by 10 publications

(10 citation statements)

References 35 publications

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“…High MPV was suggested to be associated with overall survival in various diseases such as cancer, cardiac disease, septic shock, kidney injury, and patients hospitalized in a respiratory intensive care unit (21)(22)(23)(24)(25). On the other hand, subsequent MPV and PDW are suggested to be associated with mortality in critically ill children receiving mechanical ventilation, however initial admission MPV was not associated with mortality in those children (17). There are few reports about the relationship between MPV and morbidities among large cohorts of premature newborns.…”

Section: Discussionmentioning

confidence: 99%

“…The present study shows that elevated MPV at birth correlates with unfavorable outcomes for NICU patients born after <32 weeks' gestation. While precise pathophysiologic mechanisms remain elusive, platelet numbers and average size may increase in conjunction with inflammatory and thrombotic conditions (17). Young platelets are generally larger than old ones, and the presence of more young platelets indicates increased production in response to consumption, which in turn may be provoked by inflammation.…”

Section: Discussionmentioning

confidence: 99%

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Using Platelet Parameters to Anticipate Morbidity and Mortality Among Preterm Neonates: A Retrospective Study

Ohto

Nollet

et al. 2020

Front. Pediatr.

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Background: Platelets participate in many physiological and pathological functions and some platelet parameters predict adult diseases. However, few studies report whether platelet parameters may reflect neonatal disease and mortality in a large cohort.Objective: We aimed to investigate whether platelet parameters could predict bronchopulmonary dysplasia (BPD), necrotizing enterocolitis (NEC), intraventricular hemorrhage (IVH), and NICU mortality. Study Design and Methods:This retrospective cohort study examined records from 2006 to 2017 at the neonatal intensive care unit (NICU) of Fukushima Medical University Hospital. We retrospectively investigated platelet count, plateletcrit (PCT), mean platelet volume (MPV), and platelet distribution width (PDW) on the first day of life in preterm newborns born <32 weeks' gestation admitted to our NICU from 2006 to 2017. Receiver operating characteristic (ROC) and multiple regression analyses, along with Cox proportional hazard modeling, identified independent predictors of morbidities and mortality in preterm newborns.Results: Of 1,501 neonates admitted to our NICU, a total of 305 preterm newborns were included in this study. Gestational age, birth weight, and Apgar score were significantly lower in non-survivors than in survivors. Platelet count, PCT, PDW and PMI did not differ significantly between the two groups, whereas mean MPV in non-survivors was significantly higher than in survivors (10.5 fl vs. 10.0 fl, p = 0.001). Multivariate Cox hazard modeling showed that shorter GA [HR: 0.628, 95% CI: 0.464-0.840, p = 0.003], male sex [HR: 0.269, 95% CI: 0.113-0.640, p = 0.001], and MPV [HR: 1.469, 95% CI: 1.046-2.063, p = 0.026] independently predicted overall survival. Per receiver operating curve, an MPV threshold of 10.2 fl. MPV predicts prognosis in neonates with a sensitivity of 72.4% and a specificity of 58.6% (AUC = 0.685, 95% CI: 0.600-0.789, p = 0.001). Furthermore, multivariate analysis revealed that platelet parameters were not associated Go et al. Platelet Parameters in Neonateswith BPD and NEC, whereas small for gestational age (SGA), Apgar score at 5 min, and low PCT were associated with intraventricular hemorrhage (IVH).Conclusion: This study demonstrates that low PCT predicts IVH, and MPV ≥ 10.2 fL correlates with mortality among infants born after <32 weeks' gestation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Using Platelet Parameters to Anticipate Morbidity and Mortality Among Preterm Neonates: A Retrospective Study

Ohto

Nollet

et al. 2020

Front. Pediatr.

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“…A retrospective study by Ye et al on critically ill children receiving mechanical ventilation reported that there were significant associations between PCT and PDW with mortality. These studies also demonstrated that patients with a low platelet count and high MPV and PDW survived for a shorter time than those with normal platelet indices; thus, platelet indices were proposed as a novel prognostic indicator in critically ill patients [14]. Similarly, Aydemir et al show that increase in MPV values was statistically significant for the first 3 days of sepsis [7].…”

Section: Discussionmentioning

confidence: 94%

Platelet Profile as Prognostic Factor in Critically ill Children

Yanni¹,

Saragih²

2020

Open Access Maced J Med Sci

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BACKGROUND: Previous studies showed that platelet profile may reflect the platelet function better than the platelet count itself, but the study on its use as a prognostic indicator in critically ill children is still limited. AIM: We analyzed the association between platelet profile such as platelet count, plateletcrit (PCT), mean platelet volume (MPV), and platelet distribution width (PDW) and mortality, also its correlation with pediatric logistic organ dysfunction-2 (PELOD-2) score in critically ill children admitted to the pediatric intensive care unit (PICU). METHODS: A prospective cohort study was conducted in PICU Haji Adam Malik General Hospital, Medan. Assessment of platelet profile (platelet count, PCT, MPV, and PDW) and PELOD score on the 1st and 3rd day of PICU admission were performed. RESULTS: Eighty-three subjects were recruited in this study, 44 were boy with a median age of 6 (1–17) years old. The septic patient was 43 subjects (51.8%). Platelet count on the 1st day (p = 0.024) and PDW on the 3rd day (p = 0.018) of PICU admission was significantly associated with mortality. There was no correlation between platelet profile and PELOD-2 score on day 1 and 3. However, the difference between MPV on days 1 and 3 (ΔMPV) significantly correlated with the change of PELOD-2 score (r = 0,647, p < 0.0001). CONCLUSION: Platelet count on 1st day and PDW on the 3rd day had a significant association with mortality but no correlation between platelet profile and PELOD-2 score.

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“…So, we speculate that MPV could represent a relevant predictive marker of mortality in premature neonates with late-onset sepsis. While precise pathophysiologic mechanisms remain elusive, platelet average size may increase in conjunction with inflammation [ 26 ]. Moreover, elevated MPV may be indicative of oxidative stress in newborns [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Mean platelet volume and red blood cell distribution width is associated with prognosis in premature neonates with sepsis

et al. 2021

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Objective To evaluate the prognostic value of the mean platelet volume (MPV) and red blood cell distribution width (RDW) in sepsis among premature neonates. Methods This was a retrospective cohort study conducted in the neonatal intensive care unit between May 2015 and May 2020. Premature neonates with late-onset sepsis were enrolled. The demographic data, blood cell count analysis, C-reactive protein, and blood culture were compared between survivors and non-survivors. Results A total of 73 premature neonates with sepsis in the survivor group and 10 cases in the non-survivor group. Significant differences were observed between the survivor and non-survivor groups with regard to birth weight, MPV, and RDW (P < 0.05). The results of binomial stepwise logistic regression suggested that MPV (OR = 3.226, P = 0.017 < 0.05) and RDW (OR = 2.058, P = 0.019 < 0.05) were independent predictor for prognosis in preterm with sepsis. A receiver operating characteristic analysis showed that the areas under the curves were 0.738 for MPV alone, 0.768 for RDW alone, and 0.854 for MPV combined with RDW. Conclusion MPV and RDW were independent predictors of prognosis and the combination of the two helps in predicting the prognosis of preterm with late-onset sepsis in the early stage.

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Are platelet volume indices related to mortality in hospitalized children on mechanical ventilation?

Cited by 10 publications

References 35 publications

Using Platelet Parameters to Anticipate Morbidity and Mortality Among Preterm Neonates: A Retrospective Study

Using Platelet Parameters to Anticipate Morbidity and Mortality Among Preterm Neonates: A Retrospective Study

Platelet Profile as Prognostic Factor in Critically ill Children

Mean platelet volume and red blood cell distribution width is associated with prognosis in premature neonates with sepsis

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